School of Chemistry - Research Publications

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Author: Caruso, Francesco × Author: Mulvaney, Paul × Start date: 2000 ×

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    Tutorials and Articles on Best Practices
    Schaak, RE ; Penner, RM ; Buriak, JM ; Caruso, F ; Chhowalla, M ; Gogotsi, Y ; Mulvaney, P ; Parak, WJ ; Weiss, PS (AMER CHEMICAL SOC, 2020-09-22)
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    The Future of Layer-by-Layer Assembly: A Tribute to ACS Nano Associate Editor Helmuth Mohwald
    Zhao, S ; Caruso, F ; Daehne, L ; Decher, G ; De Geest, BG ; Fan, J ; Feliu, N ; Gogotsi, Y ; Hammond, PT ; Hersam, MC ; Khademhosseini, A ; Kotov, N ; Leporatti, S ; Li, Y ; Lisdat, F ; Liz-Marzan, LM ; Moya, S ; Mulvaney, P ; Rogach, AL ; Roy, S ; Shchukin, DG ; Skirtach, AG ; Stevens, MM ; Sukhorukov, GB ; Weiss, PS ; Yue, Z ; Zhu, D ; Parak, WJ (AMER CHEMICAL SOC, 2019-06)
    Layer-by-layer (LbL) assembly is a widely used tool for engineering materials and coatings. In this Perspective, dedicated to the memory of ACS Nano associate editor Prof. Dr. Helmuth Möhwald, we discuss the developments and applications that are to come in LbL assembly, focusing on coatings, bulk materials, membranes, nanocomposites, and delivery vehicles.
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    Standardizing Nanomaterials
    Mulvaney, P ; Parak, WJ ; Caruso, F ; Weiss, PS (AMER CHEMICAL SOC, 2016-11)
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    Monitoring ion-channel function in real time through quantum decoherence
    Hall, LT ; Hill, CD ; Cole, JH ; Staedler, B ; Caruso, F ; Mulvaney, P ; Wrachtrup, J ; Hollenberg, LCL (NATL ACAD SCIENCES, 2010-11-02)
    In drug discovery, there is a clear and urgent need for detection of cell-membrane ion-channel operation with wide-field capability. Existing techniques are generally invasive or require specialized nanostructures. We show that quantum nanotechnology could provide a solution. The nitrogen-vacancy (NV) center in nanodiamond is of great interest as a single-atom quantum probe for nanoscale processes. However, until now nothing was known about the quantum behavior of a NV probe in a complex biological environment. We explore the quantum dynamics of a NV probe in proximity to the ion channel, lipid bilayer, and surrounding aqueous environment. Our theoretical results indicate that real-time detection of ion-channel operation at millisecond resolution is possible by directly monitoring the quantum decoherence of the NV probe. With the potential to scan and scale up to an array-based system, this conclusion may have wide-ranging implications for nanoscale biology and drug discovery.
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    Detection of atomic spin labels in a lipid bilayer using a single-spin nanodiamond probe
    Kaufmann, S ; Simpson, DA ; Hall, LT ; Perunicic, V ; Senn, P ; Steinert, S ; McGuinness, LP ; Johnson, BC ; Ohshima, T ; Caruso, F ; Wrachtrup, J ; Scholten, RE ; Mulvaney, P ; Hollenberg, L (NATL ACAD SCIENCES, 2013-07-02)
    Magnetic field fluctuations arising from fundamental spins are ubiquitous in nanoscale biology, and are a rich source of information about the processes that generate them. However, the ability to detect the few spins involved without averaging over large ensembles has remained elusive. Here, we demonstrate the detection of gadolinium spin labels in an artificial cell membrane under ambient conditions using a single-spin nanodiamond sensor. Changes in the spin relaxation time of the sensor located in the lipid bilayer were optically detected and found to be sensitive to near-individual (4 ± 2) proximal gadolinium atomic labels. The detection of such small numbers of spins in a model biological setting, with projected detection times of 1 s [corresponding to a sensitivity of ∼5 Gd spins per Hz(1/2)], opens a pathway for in situ nanoscale detection of dynamical processes in biology.