School of Chemistry - Research Publications

Permanent URI for this collection

http://hdl.handle.net/11343/300

Filters

2015 - 2017 3
Reset filters

Settings
Statistics
Citations
Author: Donnelly, Paul × Author: NORTH, ANDREA × Author: White, Jonathan × End date: 2019 × Start date: 2011 × Type: Journal Article ×

Search Results

Now showing 1 - 3 of 3
  • Item
    Thumbnail Image
    Synthesis of Homochiral Co-III- and Mn-IV-[2.2]Paracyclophane Schiff Base Complexes with Predetermined Chirality at the Metal Centre
    Loits, D ; Braese, S ; North, AJ ; White, JM ; Donnelly, PS ; Rizzacasa, MA (WILEY-V C H VERLAG GMBH, 2016-08-01)
    The planar chiral Schiff base ligand 2, derived from (Rp)‐5‐formyl‐4‐hydroxy‐[2.2]paracyclophane (FHPC) (1), was utilised to form a Λ‐CoIII cis‐β‐octahedral metal complex 3 with complete control of the metal‐centred chirality. In addition, a di‐µ‐oxo Λ,Λ‐MnIV complex 4 was synthesised with control of both metal‐centred and (P)‐helical chirality.
  • Item
    No Preview Available
    Rhenium and Technetium-oxo Complexes with Thioamide Derivatives of Pyridylhydrazine Bifunctional Chelators Conjugated to the Tumour Targeting Peptides Octreotate and Cyclic-RGDfK
    North, AJ ; Karas, JA ; Ma, MT ; Blower, PJ ; Ackermann, U ; White, JM ; Donnelly, PS (AMER CHEMICAL SOC, 2017-08-21)
    This research aimed to develop new tumor targeted theranostic agents taking advantage of the similarities in coordination chemistry between technetium and rhenium. A γ-emitting radioactive isotope of technetium is commonly used in diagnostic imaging, and there are two β- emitting radioactive isotopes of rhenium that have the potential to be of use in radiotherapy. Variants of the 6-hydrazinonicotinamide (HYNIC) bifunctional ligands have been prepared by appending thioamide functional groups to 6-hydrazinonicotinamide to form pyridylthiosemicarbazide ligands (SHYNIC). The new bidentate ligands were conjugated to the tumor targeting peptides Tyr3-octreotate and cyclic-RGD. The new ligands and conjugates were used to prepare well-defined {M═O}3+ complexes (where M = 99mTc or natRe or 188Re) that feature two targeting peptides attached to the single metal ion. These new SHYNIC ligands are capable of forming well-defined rhenium and technetium complexes and offer the possibility of using the 99mTc imaging and 188/186Re therapeutic matched pairs.
  • Item
    Thumbnail Image
    Rhenium and technetium complexes that bind to amyloid-β plaques
    Hayne, DJ ; North, AJ ; Fodero-Tavoletti, M ; White, JM ; Hung, LW ; Rigopoulos, A ; McLean, CA ; Adlard, PA ; Ackermann, U ; Tochon-Danguy, H ; Villemagne, VL ; Barnham, KJ ; Donnelly, PS (ROYAL SOC CHEMISTRY, 2015)
    Alzheimer's disease is associated with the presence of insoluble protein deposits in the brain called amyloid plaques. The major constituent of these deposits is aggregated amyloid-β peptide. Technetium-99m complexes that bind to amyloid-β plaques could provide important diagnostic information on amyloid-β plaque burden using Single Photon Emission Computed Tomography (SPECT). Tridentate ligands with a stilbene functional group were used to form complexes with the fac-[M(I)(CO)3](+) (M = Re or (99m)Tc) core. The rhenium carbonyl complexes with tridentate co-ligands that included a stilbene functional group and a dimethylamino substituent bound to amyloid-β present in human frontal cortex brain tissue from subjects with Alzheimer's disease. This chemistry was extended to make the analogous [(99m)Tc(I)(CO)3](+) complexes and the complexes were sufficiently stable in human serum. Whilst the lipophilicity (log D7.4) of the technetium complexes appeared ideally suited for penetration of the blood-brain barrier, preliminary biodistribution studies in an AD mouse model (APP/PS1) revealed relatively low brain uptake (0.24% ID g(-1) at 2 min post injection).