School of Chemistry - Research Publications

Permanent URI for this collection

Now showing 1 - 1 of 1

Pre-targeting amyloid-β with antibodies for potential molecular imaging of Alzheimer's disease

Morgan, KA ; de Veer, M ; Miles, LA ; Kelderman, CAA ; McLean, CA ; Masters, CL ; Barnham, KJ ; White, JM ; Paterson, BM ; Donnelly, PS (ROYAL SOC CHEMISTRY, 2023-02-21)

With the aim of developing the concept of pretargeted click chemistry for the diagnosis of Alzheimer's disease two antibodies specific for amyloid-β were modified to incorporate trans-cyclooctene functional groups. Two bis(thiosemicarbazone) compounds with pendant 1,2,4,5-tetrazine functional groups were prepared and radiolabelled with positron emitting copper-64. The new copper-64 complexes rapidly react with the trans-cyclooctene functionalized antibodies in a bioorthogonal click reaction and cross the blood-brain barrier in mice.