School of Chemistry - Research Publications

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Type: Journal Article × Author: Caruso, Francesco × Author: Cui, Jiwei × Author: LIANG, KANG × Start date: 2011 × End date: 2019 ×

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Now showing 1 - 4 of 4
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    One-Step Assembly of Coordination Complexes for Versatile Film and Particle Engineering
    Ejima, H ; Richardson, JJ ; Liang, K ; Best, JP ; van Koeverden, MP ; Such, GK ; Cui, J ; Caruso, F (AMER ASSOC ADVANCEMENT SCIENCE, 2013-07-12)
    The development of facile and versatile strategies for thin-film and particle engineering is of immense scientific interest. However, few methods can conformally coat substrates of different composition, size, shape, and structure. We report the one-step coating of various interfaces using coordination complexes of natural polyphenols and Fe(III) ions. Film formation is initiated by the adsorption of the polyphenol and directed by pH-dependent, multivalent coordination bonding. Aqueous deposition is performed on a range of planar as well as inorganic, organic, and biological particle templates, demonstrating an extremely rapid technique for producing structurally diverse, thin films and capsules that can disassemble. The ease, low cost, and scalability of the assembly process, combined with pH responsiveness and negligible cytotoxicity, makes these films potential candidates for biomedical and environmental applications.
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    Mechanically Tunable, Self-Adjuvanting Nanoengineered Polypeptide Particles
    Cui, J ; De Rose, R ; Best, JP ; Johnston, APR ; Alcantara, S ; Liang, K ; Such, GK ; Kent, SJ ; Caruso, F (WILEY-V C H VERLAG GMBH, 2013-07-05)
    DNA-loaded polypeptide particles are prepared via templated assembly of mesoporous silica for the delivery of adjuvants. The elasticity and cargo-loading capacity of the obtained particles can be tuned by the amount of cross-linker used to stabilize the polypeptide particles. The use of polypeptide particles as biocarriers provides a promising method for vaccine delivery.
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    Peptide-Tunable Drug Cytotoxicity via One-Step Assembled Polymer Nanoparticles
    Liang, K ; Richardson, JJ ; Ejima, H ; Such, GK ; Cui, J ; Caruso, F (WILEY-V C H VERLAG GMBH, 2014-04)
    A novel class of nanoparticles is developed for the co-delivery of a short cell penetrating peptide and a chemotherapeutic drug to achieve enhanced cytotoxicity. Tunable cytotoxicity is achieved through non-toxic peptide-facilitated gating. The strategy relies on a one-step blending process from polymer building blocks to form monodisperse, PEGylated particles that are sensitive to cellular pH variations. By varying the amount of peptide loading, the chemotherapeutic effects can be enhanced by up to 30-fold.
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    Endocytic pH-Triggered Degradation of Nanoengineered Multilayer Capsules
    Liang, K ; Such, GK ; Johnston, APR ; Zhu, Z ; Ejima, H ; Richardson, JJ ; Cui, J ; Caruso, F (WILEY-V C H VERLAG GMBH, 2014-03)
    The synthesis of cross-linker free layer-by-layer (LbL) capsules that solely utilize cellular pH variations as a trigger to specifically deconstruct and subsequently release cargo in cells is reported. These capsules demonstrate retention of water-soluble therapeutic molecules as small as 500 Da at extracellular pH. Triggered capsule degradation and release of cargo is observed within 30 min of cell uptake.