School of Agriculture, Food and Ecosystem Sciences - Research Publications

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    The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019
    Alvarez, EM ; Force, LM ; Xu, R ; Compton, K ; Lu, D ; Henrikson, HJ ; Kocarnik, JM ; Harvey, JD ; Pennini, A ; Dean, FE ; Fu, W ; Vargas, MT ; Keegan, THM ; Ariffin, H ; Barr, RD ; Erdomaeva, YA ; Gunasekera, DS ; John-Akinola, YO ; Ketterl, TG ; Kutluk, T ; Malogolowkin, MH ; Mathur, P ; Radhakrishnan, V ; Ries, LAG ; Rodriguez-Galindo, C ; Sagoyan, GB ; Sultan, I ; Abbasi, B ; Abbasi-Kangevari, M ; Abbasi-Kangevari, Z ; Abbastabar, H ; Abdelmasseh, M ; Abd-Elsalam, S ; Abdoli, A ; Abebe, H ; Abedi, A ; Abidi, H ; Abolhassani, H ; Ali, HA ; Abu-Gharbieh, E ; Achappa, B ; Acuna, JM ; Adedeji, IA ; Adegboye, OA ; Adnani, QES ; Advani, SM ; Afzal, MS ; Meybodi, MA ; Ahadinezhad, B ; Ahinkorah, BO ; Ahmad, S ; Ahmadi, S ; Ahmed, MB ; Rashid, TA ; Salih, YA ; Aiman, W ; Akalu, GT ; Al Hamad, H ; Alahdab, F ; AlAmodi, AA ; Alanezi, FM ; Alanzi, TM ; Alem, AZ ; Alem, DT ; Alemayehu, Y ; Alhalaiqa, FN ; Alhassan, RK ; Ali, S ; Alicandro, G ; Alipour, V ; Aljunid, SM ; Alkhayyat, M ; Alluri, S ; Almasri, NA ; Al-Maweri, SA ; Almustanyir, S ; Al-Raddadi, RM ; Alvis-Guzman, N ; Ameyaw, EK ; Amini, S ; Amu, H ; Ancuceanu, R ; Andrei, CL ; Andrei, T ; Ansari, F ; Ansari-Moghaddam, A ; Anvari, D ; Anyasodor, AE ; Arabloo, J ; Arab-Zozani, M ; Argaw, AM ; Arshad, M ; Arulappan, J ; Aryannejad, A ; Asemi, Z ; Jafarabadi, MA ; Atashzar, MR ; Atorkey, P ; Atreya, A ; Attia, S ; Aujayeb, A ; Ausloos, M ; Avila-Burgos, L ; Awedew, AF ; Quintanilla, BPA ; Ayele, AD ; Ayen, SS ; Azab, MA ; Azadnajafabad, S ; Azami, H ; Azangou-Khyavy, M ; Jafari, AA ; Azarian, G ; Azzam, AY ; Bahadory, S ; Bai, J ; Baig, AA ; Baker, JL ; Banach, M ; Barnighausen, TW ; Barone-Adesi, F ; Barra, F ; Barrow, A ; Basaleem, H ; Batiha, A-MM ; Behzadifar, M ; Bekele, NC ; Belete, R ; Belgaumi, UI ; Bell, AW ; Berhie, AY ; Bhagat, DS ; Bhagavathula, AS ; Bhardwaj, N ; Bhardwaj, P ; Bhaskar, S ; Bhattacharyya, K ; Bhojaraja, VS ; Bibi, S ; Bijani, A ; Biondi, A ; Birara, S ; Bjorge, T ; Bolarinwa, OA ; Bolla, SR ; Boloor, A ; Braithwaite, D ; Brenner, H ; Bulamu, NB ; Burkart, K ; Bustamante-Teixeira, MT ; Butt, NS ; Butt, ZA ; dos Santos, FLC ; Cao, C ; Cao, Y ; Carreras, G ; Catala-Lopez, F ; Cembranel, F ; Cerin, E ; Chakinala, RC ; Chakraborty, PA ; Chattu, VK ; Chaturvedi, P ; Chaurasia, A ; Chavan, PP ; Chimed-Ochir, O ; Choi, J-YJ ; Christopher, DJ ; Chu, D-T ; Chung, MT ; Conde, J ; Costa, VM ; Daar, OB ; Dadras, O ; Dahlawi, SMA ; Dai, X ; Damiani, G ; Amico, ED ; Dandona, L ; Dandona, R ; Daneshpajouhnejad, P ; Darwish, AH ; Daryani, A ; De la Hoz, FP ; Debela, SA ; Demie, TGG ; Demissie, GD ; Demissie, ZG ; Denova-Gutierrez, E ; Molla, MD ; Desai, R ; Desta, AA ; Dhamnetiya, D ; Dharmaratne, SD ; Dhimal, ML ; Dhimal, M ; Dianatinasab, M ; Didehdar, M ; Diress, M ; Djalalinia, S ; Huyen, PD ; Doaei, S ; Dorostkar, F ; dos Santos, WM ; Drake, TM ; Ekholuenetale, M ; El Sayed, I ; Zaki, MES ; El Tantawi, M ; El-Abid, H ; Elbahnasawy, MA ; Elbarazi, I ; Elhabashy, HR ; Elhadi, M ; El-Jaafary, S ; Enyew, DB ; Erkhembayar, R ; Eshrati, B ; Eskandarieh, S ; Faisaluddin, M ; Fares, J ; Farooque, U ; Fasanmi, AO ; Fatima, W ; Ferreira de Oliveira, JMP ; Ferrero, S ; Desideri, LF ; Fetensa, G ; Filip, I ; Fischer, F ; Fisher, JL ; Foroutan, M ; Fukumoto, T ; Gaal, PA ; Gad, MM ; Gaewkhiew, P ; Gallus, S ; Garg, T ; Gemeda, BNB ; Getachew, T ; Ghafourifard, M ; Ghamari, S-H ; Ghashghaee, A ; Ghassemi, F ; Ghith, N ; Gholami, A ; Navashenaq, JG ; Gilani, SA ; Ginindza, TG ; Gizaw, AT ; Glasbey, JC ; Goel, A ; Golechha, M ; Goleij, P ; Golinelli, D ; Gopalani, SV ; Gorini, G ; Goudarzi, H ; Goulart, BNG ; Grada, A ; Gubari, MIM ; Guerra, MR ; Guha, A ; Gupta, B ; Gupta, S ; Gupta, VB ; Gupta, VK ; Haddadi, R ; Hafezi-Nejad, N ; Hailu, A ; Haj-Mirzaian, A ; Halwani, R ; Hamadeh, RR ; Hambisa, MT ; Hameed, S ; Hamidi, S ; Haque, S ; Hariri, S ; Haro, JM ; Hasaballah, A ; Hasan, SMM ; Hashemi, SM ; Hassan, TS ; Hassanipour, S ; Hay, S ; Hayat, K ; Hebo, SH ; Heidari, G ; Heidari, M ; Herrera-Serna, BY ; Herteliu, C ; Heyi, DZ ; Hezam, K ; Hole, MK ; Holla, R ; Horita, N ; Hossain, MM ; Hossain, MB ; Hosseini, M-S ; Hosseini, M ; Hosseinzadeh, A ; Hosseinzadeh, M ; Hostiuc, M ; Hostiuc, S ; Househ, M ; Hsairi, M ; Huang, J ; Hussein, NR ; Hwang, B-F ; Ibitoye, SE ; Ilesanmi, OS ; Ilic, IM ; Ilic, MD ; Innos, K ; Irham, LM ; Islam, RM ; Islam, SMS ; Ismail, NE ; Isola, G ; Iwagami, M ; Jacob, L ; Jadidi-Niaragh, F ; Jain, V ; Jakovljevic, M ; Janghorban, R ; Mamaghani, AJ ; Jayaram, S ; Jayawardena, R ; Jazayeri, SB ; Jebai, R ; Jha, RP ; Joo, T ; Joseph, N ; Joukar, F ; Jurisson, M ; Kaambwa, B ; Kabir, A ; Kalankesh, LR ; Kaliyadan, F ; Kamal, Z ; Kamath, A ; Kandel, H ; Kar, SS ; Karaye, IM ; Karimi, A ; Kassa, BG ; Kauppila, JH ; Bohan, PMK ; Kengne, AP ; Kerbo, AA ; Keykhaei, M ; Khader, YS ; Khajuria, H ; Khalili, N ; Khan, EA ; Khan, G ; Khan, M ; Khan, MN ; Khan, MAB ; Khanali, J ; Khayamzadeh, M ; Khosravizadeh, O ; Khubchandani, J ; Khundkar, R ; Kim, MS ; Kim, YJ ; Kisa, A ; Kisa, S ; Kissimova-Skarbek, K ; Kolahi, A-A ; Kopec, JA ; Koteeswaran, R ; Laxminarayana, SLK ; Koyanagi, A ; Kugbey, N ; Kumar, GA ; Kumar, N ; Kwarteng, A ; La Vecchia, C ; Lan, Q ; Landires, I ; Lasrado, S ; Lauriola, P ; Ledda, C ; Lee, S-W ; Lee, W-C ; Lee, YY ; Lee, YH ; Leigh, J ; Leong, E ; Li, B ; Li, J ; Li, M-C ; Lim, SS ; Liu, X ; Lobo, SW ; Loureiro, JA ; Lugo, A ; Lunevicius, R ; Abd El Razek, HM ; Razek, MMAE ; Mahmoudi, M ; Majeed, A ; Makki, A ; Male, S ; Malekpour, M-R ; Malekzadeh, R ; Malik, AA ; Mamun, MA ; Manafi, N ; Mansour-Ghanaei, F ; Mansouri, B ; Mansournia, MA ; Martini, S ; Masoumi, SZ ; Matei, CN ; Mathur, MR ; McAlinden, C ; Mehrotra, R ; Mendoza, W ; Menezes, RG ; Mentis, A-FA ; Meretoja, TJ ; Mersha, AG ; Mesregah, MK ; Mestrovic, T ; Jonasson, JM ; Miazgowski, B ; Michalek, IM ; Miller, TR ; Mingude, AB ; Mirmoeeni, S ; Mirzaei, H ; Misra, S ; Mithra, P ; Mohammad, KA ; Mohammadi, M ; Mohammadi, SM ; Mohammadian-Hafshejani, A ; Mohammadpourhodki, R ; Mohammed, A ; Mohammed, S ; Mohammed, TA ; Moka, N ; Mokdad, AH ; Molokhia, M ; Momtazmanesh, S ; Monasta, L ; Moni, MA ; Moradi, G ; Moradi, Y ; Moradzadeh, M ; Moradzadeh, R ; Moraga, P ; Morrison, SD ; Mostafavi, E ; Khaneghah, AM ; Mpundu-Kaambwa, C ; Mubarik, S ; Mwanri, L ; Nabhan, AF ; Nagaraju, SP ; Nagata, C ; Naghavi, M ; Naimzada, MD ; Naldi, L ; Nangia, V ; Naqvi, AA ; Swamy, SN ; Narayana, AI ; Nayak, BP ; Nayak, VC ; Nazari, J ; Nduaguba, SO ; Negoi, I ; Negru, SM ; Nejadghaderi, SA ; Nepal, S ; Kandel, SN ; Nggada, HA ; Nguyen, CT ; Nnaji, CA ; Nosrati, H ; Nouraei, H ; Nowroozi, A ; Nunez-Samudio, V ; Nwatah, VE ; Nzoputam, CI ; Oancea, B ; Odukoya, OO ; Oguntade, AS ; Oh, I-H ; Olagunju, AT ; Olagunju, TO ; Olakunde, BO ; Oluwasanu, MM ; Omar, E ; Bali, AO ; Ong, S ; Onwujekwe, OE ; Ortega-Altamirano, D ; Otstavnov, N ; Otstavnov, SS ; Oumer, B ; Owolabi, MO ; Mahesh, PA ; Padron-Monedero, A ; Padubidri, JR ; Pakshir, K ; Pana, A ; Pandey, A ; Pardhan, S ; Kan, FP ; Pasovic, M ; Patel, JR ; Pati, S ; Pattanshetty, SM ; Paudel, U ; Pereira, RB ; Peres, MFP ; Perianayagam, A ; Postma, MJ ; Pourjafar, H ; Pourshams, A ; Prashant, A ; Pulakunta, T ; Qadir, MMFF ; Rabiee, M ; Rabiee, N ; Radfar, A ; Radhakrishnan, RA ; Rafiee, A ; Rafiei, A ; Rafiei, S ; Rahim, F ; Rahimzadeh, S ; Rahman, M ; Rahman, MA ; Rahmani, AM ; Rajesh, A ; Ramezani-Doroh, V ; Ranabhat, K ; Ranasinghe, P ; Rao, CR ; Rao, SJ ; Rashedi, S ; Rashidi, M-M ; Rath, GK ; Rawaf, DL ; Rawaf, S ; Rawal, L ; Rawassizadeh, R ; Razeghinia, MS ; Regasa, MT ; Renzaho, AMN ; Rezaei, M ; Rezaei, N ; Rezaeian, M ; Rezapour, A ; Rezazadeh-Khadem, S ; Riad, A ; Lopez, LER ; Rodriguez, JAB ; Ronfani, L ; Roshandel, G ; Rwegerera, GM ; Saber-Ayad, MM ; Sabour, S ; Saddik, B ; Sadeghi, E ; Sadeghian, S ; Saeed, U ; Sahebkar, A ; Saif-Ur-Rahman, KM ; Sajadi, SM ; Salahi, S ; Salehi, S ; Salem, MR ; Salimzadeh, H ; Samy, AM ; Sanabria, J ; Sanmarchi, F ; Sarveazad, A ; Sathian, B ; Sawhney, M ; Sawyer, SM ; Saylan, M ; Schneider, IJC ; Seidu, A-A ; Sekerija, M ; Sendo, EG ; Sepanlou, SG ; Seylani, A ; Seyoum, K ; Sha, F ; Shafaat, O ; Shaikh, MA ; Shamsoddin, E ; Shannawaz, M ; Sharma, R ; Sheikhbahaei, S ; Shetty, A ; Shetty, BSK ; Shetty, PH ; Shin, JI ; Shirkoohi, R ; Shivakumar, KM ; Shobeiri, P ; Siabani, S ; Sibhat, MM ; Malleshappa, SKS ; Sidemo, NB ; Silva, DAS ; Julian, GS ; Singh, AD ; Singh, JA ; Singh, JK ; Singh, S ; Sinke, AH ; Sintayehu, Y ; Skryabin, VY ; Skryabina, AA ; Smith, L ; Sofi-Mahmudi, A ; Soltani-Zangbar, MS ; Song, S ; Spurlock, EE ; Steiropoulos, P ; Straif, K ; Subedi, R ; Sufiyan, MB ; Abdulkader, RS ; Sultana, S ; Szerencses, V ; Szocska, M ; Tabaeian, SP ; Tabaras-Seisdedos, R ; Tabary, M ; Tabuchi, T ; Tadbiri, H ; Taheri, M ; Taherkhani, A ; Takahashi, K ; Tampa, M ; Tan, K-K ; Tat, VY ; Tavakoli, A ; Tbakhi, A ; Tehrani-Banihashemi, A ; Temsah, M-H ; Tesfay, FH ; Tesfaye, B ; Thakur, JS ; Thapar, R ; Thavamani, A ; Thiyagarajan, A ; Thomas, N ; Tobe-Gai, R ; Togtmol, M ; Tohidast, SA ; Tohidinik, HR ; Tolani, MA ; Tollosa, DN ; Touvier, M ; Tovani-Palone, MR ; Traini, E ; Bach, XT ; Mai, TNT ; Tripathy, JP ; Tusa, BS ; Ukke, GG ; Ullah, I ; Ullah, S ; Umapathi, KK ; Unnikrishnan, B ; Upadhyay, E ; Ushula, TW ; Vacante, M ; Tahbaz, SV ; Varthya, SB ; Veroux, M ; Villeneuve, PJ ; Violante, FS ; Vlassov, V ; Giang, TV ; Waheed, Y ; Wang, N ; Ward, P ; Weldesenbet, AB ; Wen, YF ; Westerman, R ; Winkler, AS ; Wubishet, BL ; Xu, S ; Jabbari, SHY ; Yang, L ; Yaya, S ; Yazdi-Feyzabadi, V ; Yazie, TS ; Yehualashet, SS ; Yeshaneh, A ; Yeshaw, Y ; Yirdaw, BW ; Yonemoto, N ; Younis, MZ ; Yousefi, Z ; Yu, C ; Yunusa, I ; Zadnik, V ; Zahir, M ; Moghadam, TZ ; Zamani, M ; Zamanian, M ; Zandian, H ; Zare, F ; Zastrozhin, MS ; Zastrozhina, A ; Zhang, J ; Zhang, Z-J ; Ziapour, A ; Zoladl, M ; Murray, CJL ; Fitzmaurice, C ; Bleyer, A ; Bhakta, N ; Gebremeskel, TG (ELSEVIER SCIENCE INC, 2022-01)
    BACKGROUND: In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. METHODS: Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. FINDINGS: There were 1·19 million (95% UI 1·11-1·28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59·6 [54·5-65·7] per 100 000 person-years) and high-middle SDI countries (53·2 [48·8-57·9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14·2 [12·9-15·6] per 100 000 person-years) and middle SDI (13·6 [12·6-14·8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23·5 million (21·9-25·2) DALYs to the global burden of disease, of which 2·7% (1·9-3·6) came from YLDs and 97·3% (96·4-98·1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. INTERPRETATION: Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. FUNDING: Bill & Melinda Gates Foundation, American Lebanese Syrian Associated Charities, St Baldrick's Foundation, and the National Cancer Institute.
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    Framing ocean acidification to mobilise action under multilateral environmental agreements
    Harrould-Kolieb, ER (ELSEVIER SCI LTD, 2020-02)
    Ocean acidification has long been framed by its epistemic community as a problem of carbon dioxide emissions that is concurrent to climate change. Framing ocean acidification in this way has been effective at garnering policy action at the domestic level in the United States. It is argued, however, in this paper that this framing has been counterproductive at the international level, resulting in two main impediments to the international governance of this issue. Firstly, defining ocean acidification as a concurrent problem to climate change, rather than as an impact of it, has resulted in the United Nations Framework Convention on Climate Change being interpreted as containing no obligation to address ocean acidification. Secondly, focussing almost solely on the reduction of global emissions of carbon dioxide as the only global solution to ocean acidification has resulted in ocean and biodiversity-related regimes that do not have the mandate to regulate CO2 emissions as being viewed as without the recourse to respond. Through an examination of the causes and consequences of ocean acidification and the general objectives of existing multilateral environmental agreements, a set of alternative problem frames are developed in this paper that could be deployed to mobilize action under existing environmental regimes.
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    Decision-making of municipal urban forest managers through the lens of governance
    Ordonez, C ; Threlfall, CG ; Livesley, SJ ; Kendal, D ; Fuller, RA ; Davern, M ; van der Ree, R ; Hochuli, DF (ELSEVIER SCI LTD, 2020-02)
    Awareness of the benefits of urban trees has led many cities to develop ambitious targets to increase tree numbers and canopy cover. Policy instruments that guide the planning of cities recognize the need for new governance arrangements to implement this agenda. Urban forests are greatly influenced by the decisions of municipal managers, but there is currently no clear understanding of how municipal managers find support to implement their decisions via new governance arrangements. To fill this knowledge gap, we collected empirical data through interviews with 23 urban forest municipal managers in 12 local governments in Greater Melbourne and regional Victoria, Australia, and analysed these data using qualitative interpretative methods through a governance lens. The goal of this was to understand the issues and challenges, stakeholders, resources, processes, and rules behind the decision-making of municipal managers. Municipal managers said that urban densification and expansion were making it difficult for them to implement their strategies to increase tree numbers and canopy cover. The coordination of stakeholders was more important for managers to find support to implement their decisions than having a bigger budget. The views of the public or wider community and a municipal government culture of risk aversion were also making it difficult for municipal managers to implement their strategies. Decision-making priorities and processes were not the same across urban centres. Lack of space to grow trees in new developments, excessive tree removal, and public consultation, were ideas more frequently raised in inner urban centres, while urban expansion, increased active use of greenspaces, and lack of data/information about tree assets were concerns for outer and regional centres. Nonetheless, inter-departmental coordination was a common theme shared among all cities. Strengthening coordination processes is an important way for local governments to overcome these barriers and effectively implement their urban forest strategies.
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    Evaluation of Spectral Indices for Assessing Fire Severity in Australian Temperate Forests
    Tran, BN ; Tanase, MA ; Bennett, LT ; Aponte, C (MDPI AG, 2018)
    Spectral indices derived from optical remote sensing data have been widely used for fire-severity classification in forests from local to global scales. However, comparative analyses of multiple indices across diverse forest types are few. This represents an information gap for fire management agencies in areas like temperate south-eastern Australia, which is characterised by a diversity of natural forests that vary in structure, and in the fire-regeneration strategies of the dominant trees. We evaluate 10 spectral indices across eight areas burnt by wildfires in 1998, 2006, 2007, and 2009 in south-eastern Australia. These wildfire areas encompass 13 forest types, which represent 86% of the 7.9M ha region’s forest area. Forest types were aggregated into six forest groups based on their fire-regeneration strategies (seeders, resprouters) and structure (tree height and canopy cover). Index performance was evaluated for each forest type and forest group by examining its sensitivity to four fire-severity classes (unburnt, low, moderate, high) using three independent methods (anova, separability, and optimality). For the best-performing indices, we calculated index-specific thresholds (by forest types and groups) to separate between the four severity classes, and evaluated the accuracy of fire-severity classification on independent samples. Our results indicated that the best-performing indices of fire severity varied with forest type and group. Overall accuracy for the best-performing indices ranged from 0.50 to 0.78, and kappa values ranged from 0.33 (fair agreement) to 0.77 (substantial agreement), depending on the forest group and index. Fire severity in resprouter open forests and woodlands was most accurately mapped using the delta Normalised Burnt ratio (dNBR). In contrast, dNDVI (delta Normalised difference vegetation index) performed best for open forests with mixed fire responses (resprouters and seeders), and dNDWI (delta Normalised difference water index) was the most accurate for obligate seeder closed forests. Our analysis highlighted the low sensitivity of all indices to fire impacts in Rainforest. We conclude that the optimal spectral index for quantifying fire severity varies with forest type, but that there is scope to group forests by structure and fire-regeneration strategy to simplify fire-severity classification in heterogeneous forest landscapes.
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    Molecular Basis for Lysine Specificity in the Yeast Ubiquitin-Conjugating Enzyme Cdc34
    Sadowski, M ; Suryadinata, R ; Lai, X ; Heierhorst, J ; Sarcevic, B (AMER SOC MICROBIOLOGY, 2010-05-15)
    Ubiquitin (Ub)-conjugating enzymes (E2s) and ubiquitin ligases (E3s) catalyze the attachment of Ub to lysine residues in substrates and Ub during monoubiquitination and polyubiquitination. Lysine selection is important for the generation of diverse substrate-Ub structures, which provides versatility to this pathway in the targeting of proteins to different fates. The mechanisms of lysine selection remain poorly understood, with previous studies suggesting that the ubiquitination site(s) is selected by the E2/E3-mediated positioning of a lysine(s) toward the E2/E3 active site. By studying the polyubiquitination of Sic1 by the E2 protein Cdc34 and the RING E3 Skp1/Cul1/F-box (SCF) protein, we now demonstrate that in addition to E2/E3-mediated positioning, proximal amino acids surrounding the lysine residues in Sic1 and Ub are critical for ubiquitination. This mechanism is linked to key residues composing the catalytic core of Cdc34 and independent of SCF. Changes to these core residues altered the lysine preference of Cdc34 and specified whether this enzyme monoubiquitinated or polyubiquitinated Sic1. These new findings indicate that compatibility between amino acids surrounding acceptor lysine residues and key amino acids in the catalytic core of ubiquitin-conjugating enzymes is an important mechanism for lysine selection during ubiquitination.
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    Interrelationships between fire, habitat, and mammals in a fragmented heathy woodland
    Zylinski, S ; Swan, M ; Sitters, H (Elsevier, 2022-10-15)
    Altered fire regimes threaten biodiversity, but there is limited understanding of the mechanisms driving population declines. Relationships between mammal occurrence and time since fire can be unclear because mammals respond directly to changes in habitat structure rather than time since fire per se, and patterns of regeneration can be highly variable. Previous studies have examined how mammals respond to time since fire and habitat structure separately, but rarely considered the three factors together. Furthermore, fires may interact with other threats such as habitat loss and fragmentation, also rarely incorporated into fire studies but known to influence mammal communities. Understanding each of these mechanisms and how they interact is critical for using fire effectively in conservation. We simultaneously related ground-dwelling mammal species activity to habitat structure, habitat structure to post-fire vegetation growth stage, and species activity to growth stage and landscape structure (extent of heathy woodland vegetation) using structural equation models (SEMs). This allowed us to find direct effects of growth stage on mammals, indirect effects mediated by habitat structure, and additional effects of landscape structure. Understorey cover, litter depth, and coarse woody debris responded to growth stage and were important contributors in all SEMs. Four of seven mammal species responded to at least one habitat structure variable. None of the mammal species were related directly to growth stage, but mammals were indirectly related to growth stage through the mediating influence of habitat structure. For example, western grey kangaroos were linked to recently burnt sites, but only through their negative association with litter depth. Extent of heathy woodland vegetation was also an important driver of mammal activity and was related to all but one species; two species showed a positive relationship, and four negative. Important relationships between fire and ground-dwelling mammals may be overlooked unless changes in important habitat resources are also considered. Fire management planning for fauna conservation should incorporate habitat responses as mammal responses to the fire regime may be mediated by fire-driven changes in resources. Knowing how time since fire affects important habitat structures can improve the effectiveness of using fire to manipulate these to support mammal species. Our results will help land managers understand direct and indirect effects of fire in a landscape where multiple drivers threaten biodiversity, and guide the use of prescribed fire to promote aspects of habitat structure that benefit mammals.
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    Plants, soil properties and microbes directly and positively drive ecosystem multifunctionality in a plantation chronosequence
    Wang, J ; Shi, X ; Lucas-Borja, ME ; Lam, SK ; Wang, Z ; Huang, Z (WILEY, 2022-10)
    Abstract Chinese fir (Cunninghamia lanceolata) is the main plantation species in the subtropical region of China. However, the shift in ecosystem multifunctionality with stand development remains largely unexplored for these plantations. This study used a chronosequence to investigate the variations of ecosystem multifunctionality by employing individual functions and identified its driving factors in Chinese fir plantations. The findings provide strong evidence that the individual functions of carbon stocks, water regulation and wood production increased with stand ages, but the tradeoff of individual functions did not significantly increase ecosystem multifunctionality. Soil microbial parameters (the abundances of bacteria, fungi and actinomycete), soil properties (soil moisture, total carbon and total nitrogen), and plant parameters (the shrub layer cover and total understory cover) exhibited positive correlations with ecosystem multifunctionality. The structural equation model revealed that plants, soil properties and microbes pathways explained 83% of the total variance in ecosystem multifunctionality. Results showed that plants, soil microbes and properties directly and significantly affected ecosystem multifunctionality with path coefficients of 0.404, 0.487 and 0.334, respectively. Soil microbes were identified as the top direct predictor for ecosystem multifunctionality, while plant and soil properties had strong direct and positive effects on ecosystem multifunctionality. These results verified that soil microbes, plants and soil properties directly and positively regulated ecosystem multifunctionality. Our findings demonstrate that ecosystem multifunctionality should be considered as a comprehensive ecological indicator for ecosystem services and functions, and sustainable plantation management. This study highlights the importance of conserving soil microbes for maintaining multifunctionality in Chinese fir plantations.
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    Opportunities to improve nitrogen use efficiency in an intensive vegetable system without compromising yield
    Suter, H ; Pandey, A ; Lam, SK ; Davies, R ; Hassan, R ; Riches, D ; Chen, D (WILEY, 2021-05)
    Intensive vegetable cropping systems rely heavily on nitrogen (N) inputs from multiple synthetic and organic fertilizer applications. The majority of applied N is lost to the environment through numerous pathways, including as nitrous oxide (N2 O). A field trial was conducted to examine the opportunities to reduce N input in an intensive vegetable system without compromising yield. Treatments applied were control (no N), manure (M, 408 kg N ha-1 from chicken manure), grower practice (GP, 408 kg N ha-1 from chicken manure + 195 kg N ha-1 from fertilizer), and 2/3 GP (two-thirds of the total N input in GP), all with and without 3,4-dimethylpyrazole phosphate (DMPP). Nitrogen recovery in the GP treatment was determined using 15 N-labeled fertilizer. Using only manure significantly lowered celery (Apium graveolens L.) yield and apparent N use efficiency (ANUE) compared with GP. Reducing N input by one-third did not affect yield or ANUE. Use of DMPP increased ANUE despite no yield improvement. More than 50% of the applied N in the GP treatment was lost to the environment, with almost 10 kg N ha-1 emitted as N2 O over the season, which was 67 times more than from the control. Reducing the N input by one-third or using manure only reduced N2 O emissions by more than 70% relative to GP. This study shows that there is a clear opportunity to reduce N input and N2 O emissions in high-fertilizer-input vegetable systems without compromising vegetable yield.
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    An empirical analysis of the use of agricultural mobile applications among smallholder farmers in Myanmar
    Thar, SP ; Ramilan, T ; Farquharson, RJ ; Pang, A ; Chen, D (WILEY, 2021-03)
    Abstract Mobile phone applications (apps) designed to assist smallholder farmers improve decision‐making have been revolutionizing the agriculture sector. These apps offer solutions to farmer information needs by providing weather information, crop market trends, pest and disease damage identification, and advice on pesticide and fertilizer use. They also facilitate interaction with fellow farmers, extension workers and other stakeholders in the value chain who are interested in information exchange. Much previous research has investigated the contribution of mobile apps to agricultural production. This study explored the agricultural mobile apps available in Myanmar, analyzed factors affecting their use and assessed the potential for farm‐based decision support. Our findings indicate that when introducing mobile‐based tools, focus should be given to younger, more educated farmers growing more specialized crops. The main constraints to adopt agricultural apps are lack of access to smartphone and/or internet (63%) and lack of digital knowledge (20%). However, smallholder farmers in Myanmar were optimistic and positive toward agricultural apps for effective utilization. We also found that majority of the surveyed farmers were familiar with information received through Facebook groups. Incorporating useful information and functions from an agricultural mobile app to a Facebook Page could have a more useful and sustainable impact.