Medicine (RMH) - Research Publications

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Author: Buising, Kirsty × Author: Cheng, Allen × Author: Eisen, Damon ×

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    No association between mannose-binding lectin deficiency and H1N1 2009 infection observed during the first season of this novel pandemic influenza virus
    Eisen, DP ; Marshall, C ; Dean, MM ; Sasadeusz, J ; Richards, M ; Buising, K ; Cheng, A ; Johnson, PDR ; Barr, IG ; McBryde, ES (ELSEVIER SCIENCE INC, 2011-11)
    Genetic variations in host immunity may influence susceptibility to novel infections like the recently emergent pandemic influenza virus. Prior studies demonstrated that mannose-binding lectin (MBL) inactivates influenza. Furthermore, MBL deficiency is common and appears to predispose to respiratory virus infections. Therefore, we studied whether MBL deficiency played a role in infection with the novel H1N1 2009 influenza strain in exposed health care workers. In a nested case-control study, we observed no association between phenotypic MBL deficiency, variously defined, and predisposition to H1N1 2009 influenza in 63 pairs of seropositive and seronegative participants. MBL appears to currently have little impact on innate immune responses to H1N1 2009 influenza.
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    Pandemic (H1N1) 2009 Risk for Frontline Health Care Workers
    Marshall, C ; Kelso, A ; McBryde, E ; Barr, IG ; Eisen, DP ; Sasadeusz, J ; Buising, K ; Cheng, AC ; Johnson, P ; Richards, M (CENTERS DISEASE CONTROL, 2011-06)
    To determine whether frontline health care workers (HCWs) are at greater risk for contracting pandemic (H1N1) 2009 than nonclinical staff, we conducted a study of 231 HCWs and 215 controls. Overall, 79 (17.7%) of 446 had a positive antibody titer by hemagglutination inhibition, with 46 (19.9%) of 231 HCWs and 33 (15.3%) of 215 controls positive (OR 1.37, 95% confidence interval 0.84-2.22). Of 87 participants who provided a second serum sample, 1 showed a 4-fold rise in antibody titer; of 45 patients who had a nose swab sample taken during a respiratory illness, 7 had positive results. Higher numbers of children in a participant's family and working in an intensive care unit were risk factors for infection; increasing age, working at hospital 2, and wearing gloves were protective factors. This highly exposed group of frontline HCWs was no more likely to contract pandemic (H1N1) 2009 influenza infection than nonclinical staff, which suggests that personal protective measures were adequate in preventing transmission.