Medicine (RMH) - Research Publications

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    Diagnosis, differential diagnosis and misdiagnosis of Susac syndrome
    Triplett, JD ; Qiu, J ; O'Brien, B ; Gopinath, S ; Trewin, B ; Spring, PJ ; Shaffi, M ; Ip, J ; Chan, F ; Chen, L ; Wilson, I ; Muller, C ; Beadnall, HN ; Boggild, M ; Van der Walt, A ; Roxburgh, R ; Seery, N ; Kalincik, T ; Barnett, MH ; Parratt, JDE ; Reddel, SW ; Tsang, B ; Hardy, TA (WILEY, 2022-03-25)
    BACKGROUND AND PURPOSE: Susac syndrome (SuS) is an inflammatory condition of the brain, eye and ear. Diagnosis can be challenging, and misdiagnosis is common. METHODS: This is a retrospective review of the medical records of 32 adult patients from an Australasian cohort of SuS patients. RESULTS: An alternative diagnosis prior to SuS was made in 30 patients (94%) with seven patients receiving two or more diagnoses. The median time to diagnosis of SuS was 3 months (range 0.5-100 months). The commonest misdiagnoses were migraine in 10 patients (31%), cerebral vasculitis in six (19%), multiple sclerosis in five (16%) and stroke in five (16%). Twenty-two patients were treated for alternative diagnoses, 10 of whom had further clinical manifestations prior to SuS diagnosis. At presentation seven patients (22%) met criteria for definite SuS, 19 (59%) for probable SuS and six (19%) for possible SuS. Six patients (19%) presented with brain-eye-ear involvement, 14 with brain-ear (44%), six with brain-eye (19%) and six (19%) with only brain involvement. In patients with the complete triad of symptoms the median delay to diagnosis was 3 months (range 1-9 months) compared to 5.25 months (range 0.5-100 months) for patients with encephalopathy and ocular symptoms at presentation. CONCLUSIONS: Susac syndrome patients are frequently misdiagnosed at initial presentation, despite many having symptoms or radiological features that are red flags for the diagnosis. Delayed diagnosis can lead to patient morbidity. The varied ways in which SuS can present, and clinician failure to consider or recognize SuS, appear to be the main factors leading to misdiagnosis.
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    Challenges in data linkage - experiences from an upper gastrointestinal cancer data linkage study
    Khan, N ; Ioannou, L ; Pilgrim, C ; Earnest, A ; Maharaj, A ; Croagh, D ; Liew, D ; Atwood, D ; Holland, J ; Philip, J ; Emery, J ; Ijzerman, M ; Brown, W ; Zalcberg, J ; Evans, S (OXFORD UNIV PRESS, 2021-09-01)
    IntroductionNearly one quarter of a million Australian workers experience a work injury annually and make a benefit claim through one of the nation’s eleven workers’ compensation (WC) systems. The total cost to Australian society has most recently been estimated at $61.8 billion or 4.1% of GDP. The disaggregation of legislative responsibility between jurisdictions has contributed to a lack of common data standards, and thus minimal understanding of the efficiency or effectiveness of service provision in the Australian WC sector. Objectives and ApproachThis project developed a new multi-jurisdictional work disability database including detailed information on work disability duration, health and social care service provision. Service level payment data contained in structured WC insurance claims datasets held by five large WC jurisdictions with >60% coverage of the Australian labour force was collected for all cases of work-related low back pain, fractures and limb soft tissue disease over between 2010 and 2015. Database development involved creation and coding of harmonised service-level indicators for individual episodes of healthcare provision and weekly periods of wage replacement. ResultsA total of 253,000 cases and 10.7 million service episodes are included in the database. Initial exploratory analyses focused on the frequency, prevalence, timing, intensity and continuity of General Practitioner (GP) services to each of the injury groups. Regression modelling examined occupational, injury, demographic and jurisdictional factors affecting GP service use outcomes. As anticipated, service patterns varied by injury type, age, gender and occupational group. Significant differences in service use between WC jurisdictions were observed. Conclusion / ImplicationsThis exploratory study demonstrates the feasibility of developing a population-based service level database for monitoring health service delivery to injured Australian workers. Future studies will examine the impact of jurisdictional policy differences on service delivery, and the relationship between service delivery and outcomes such as disability duration.
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    Integrating Shared Survivorship Care into an Allogeneic Bone Marrow Transplant Long Term Follow up Service
    Panek-Hudson, Y ; Ritchie, DS ; Hookey, S ; Wright, T ; Masons, K ; O'Leary, S ; Chard, L (ELSEVIER SCIENCE INC, 2020-03-01)
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    Quantitation of CMV Specific T-Cell Expansion Using T Cell Receptor Beta Locus Deep Sequencing to Identify Patients at Risk of Viral Complications
    Kuzich, JA ; Kankanige, Y ; Guinto, J ; Ryland, G ; McBean, M ; Thompson, E ; Wong, E ; Koldej, R ; Collins, J ; Westerman, D ; Ritchie, DS ; Blombery, P (ELSEVIER SCIENCE INC, 2020-03-01)
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    Cardiovascular Risk Factors and Cardiovascular Disease after Allogeneic Haematopoietic Stem Cell Transplantation
    Kirkpatrick, L ; Verma, K ; Prabahran, A ; Bajel, A ; Routledge, D ; Ritchie, DS ; Garcia, T ; Panek-Hudson, Y (Elsevier BV, 2021-03)
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    Allogeneic Haematopoietic Cell Transplantation for Mantle Cell Lymphoma Can Achieve Durable Remission and Myeloablative Conditioning Is Associated with Inferior Survival: An Australasian Bone Marrow Transplant Recipient Registry Study
    Di Ciaccio, PR ; Ritchie, DS ; Kennedy, G ; Milliken, S ; Purtill, D ; Gottlieb, D ; Perera, T ; Yeung, DT ; Larsen, SR ; Doocey, RT ; Greenwood, M ; Durrant, S ; Watson, A-M ; Butler, A ; Khot, A ; Curley, C ; Hamad, N (Elsevier BV, 2021-03)
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    Sodium zirconium cyclosilicate increases serum bicarbonate concentrations among patients with hyperkalaemia: exploratory analyses from three randomized, multi-dose, placebo-controlled trials
    Roger, SD ; Spinowitz, BS ; Lerma, E ; Fishbane, S ; Ash, SR ; Martins, JG ; Quinn, CM ; Packham, DK (OXFORD UNIV PRESS, 2021-05-01)
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    Hepatology Clinical
    Papalia, I ; Tjandra, D ; Quah, S ; Tan, C ; Gorelik, A ; Sivanesan, S ; Macrae, F (WILEY, 2020-11-01)
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    Autologous stem cell transplantation for untreated transformed indolent B-cell lymphoma in first remission: an international, multi-centre propensity-score-matched study
    Chin, CK ; Lim, KJ ; Lewis, K ; Jain, P ; Qing, Y ; Feng, L ; Cheah, CY ; Seymour, JF ; Ritchie, D ; Burbury, K ; Tam, CS ; Fowler, NH ; Fayad, LE ; Westin, JR ; Neelapu, SS ; Hagemeister, FB ; Samaniego, F ; Flowers, CR ; Nastoupil, LJ ; Dickinson, MJ (WILEY, 2020-10-16)