Medicine, Dentistry & Health Sciences Collected Works - Research Publications

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    Patient Rights and Practitioner Responsibilities During a Pandemic
    Bradfield, O ; Bennett, B ; Freckelton, I (The Federation press, 2021)
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    Response of the Rat Optic Nerve to Acute Intraocular and Intracranial Pressure Changes
    Zhao, D ; He, Z ; Van Koeverden, A ; Vingrys, AJ ; Wong, VHY ; Lim, JKH ; Nguyen, CTO ; Bui, BV ; Wang, N (Springer Singapore, 2019)
    Glaucoma is a neurodegenerative disease, characterized by the progressive death of retinal ganglion cells. Elevated intraocular pressure (IOP) is known to be an important risk factor for glaucoma; however, it is not the only force acting on the optic nerve. Intracranial pressure (ICP) also exerts an effect on the optic nerve head, effectively opposing the force applied by IOP. Indeed, this balance of forces creates a pressure gradient (or the translaminar pressure gradient) across the optic nerve head [1]. Increasingly it is thought that the pressure difference between IOP and ICP, the translaminar pressure (TLP), may be critical for the integrity of the retina and optic nerve [2], and thus ICP may be an important risk factor for glaucoma [2–6].
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    Hi-Plex for Simple, Accurate, and Cost-Effective Amplicon-based Targeted DNA Sequencing
    Pope, B ; Head, SR ; Ordoukhanian, P ; Salomon, DR (Springer, 2018)
    Hi-Plex is a suite of methods to enable simple, accurate, and cost-effective highly multiplex PCR-based targeted sequencing (Nguyen-Dumont et al., Biotechniques 58:33–36, 2015). At its core is the principle of using gene-specific primers (GSPs) to “seed” (or target) the reaction and universal primers to “drive” the majority of the reaction. In this manner, effects on amplification efficiencies across the target amplicons can, to a large extent, be restricted to early seeding cycles. Product sizes are defined within a relatively narrow range to enable high-specificity size selection, replication uniformity across target sites (including in the context of fragmented input DNA such as that derived from fixed tumor specimens (Nguyen-Dumont et al., Biotechniques 55:69–74, 2013; Nguyen-Dumont et al., Anal Biochem 470:48–51, 2015), and application of high-specificity genetic variant calling algorithms (Pope et al., Source Code Biol Med 9:3, 2014; Park et al., BMC Bioinformatics 17:165, 2016). Hi-Plex offers a streamlined workflow that is suitable for testing large numbers of specimens without the need for automation.
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    Bring-your-own-device usage trends in australian hospitals a national survey
    Wani, TA ; Mendoza, A ; Gray, K (IOS Press, 2021-04-19)
    Background: Healthcare is among the leading industries which drives the use of personal devices for work purposes (BYOD). However, allowing BYOD for healthcare workers comes at a cost, as it puts sensitive information assets such as patient data residing on personal devices at risk of potential data breaches. Objective: Previous review of the literature has highlighted the dearth of empirical studies in hospital settings regarding BYOD usage. As such, this paper aims to report BYOD usage trends in Australian hospitals through a national survey, first of its kind in Australia. Methods: An anonymous survey was conducted online among health IT personnel, asking them about their experiences about BYOD usage in their hospitals. 28 responses were collected based on public Australian hospitals, which included 21 hospital groups and 7 standalone hospitals, likely to represent more than 100 hospitals in total. Survey responses were quantitatively analysed through descriptive statistical analysis and cross tabulation. Results: BYOD is allowed in majority of the hospitals, and among all major staff groups, with doctors being the leading group. Participants ranked reasons for allowing BYOD, and most of them were related to improvement in clinical productivity, efficiency and mobility for clinical staff. Challenges were generally related to data security such as patient data breaches and compliance with data security laws, according to them. More than two thirds of hospitals had a cybersecurity officer employed, and CIOs were the most dominant group who held responsibility for managing BYOD within the hospital. Conclusion: This paper provides a starting point for better understanding of BYOD usage in a complex healthcare environment based on empirical evidence, one which highlights the security-usability conundrum, confirming previous literature themes.