Medical Biology - Research Publications

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Author: Angrisano, Fiona × Author: Longley, Rhea × Author: Mueller, Ivo × Author: Robinson, Leanne × End date: 2022 × Start date: 2020 × Type: Journal Article ×

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    SARS-CoV-2 Multi-Antigen Serology Assay
    Mazhari, R ; Ruybal-Pesantez, S ; Angrisano, F ; Kiernan-Walker, N ; Hyslop, S ; Longley, RJ ; Bourke, C ; Chen, C ; Williamson, DA ; Robinson, LJ ; Mueller, I ; Eriksson, EM (MDPI, 2021-12)
    Serology tests are extremely useful for assessing whether a person has been infected with a pathogen. Since the onset of the COVID-19 pandemic, measurement of anti-SARS-CoV-2-specific antibodies has been considered an essential tool in identifying seropositive individuals and thereby understanding the extent of transmission in communities. The Luminex system is a bead-based technology that has the capacity to assess multiple antigens simultaneously using very low sample volumes and is ideal for high-throughput studies. We have adapted this technology to develop a COVID-19 multi-antigen serological assay. This protocol described here carefully outlines recommended steps to optimize and establish this method for COVID-19-specific antibody measurement in plasma and in saliva. However, the protocol can easily be customized and thus the assay is broadly applicable to measure antibodies to other pathogens.