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    Synthesis and antiplasmodial activity of 3-furyl and 3-thienylquinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives.
    Vicente, E ; Charnaud, S ; Bongard, E ; Villar, R ; Burguete, A ; Solano, B ; Ancizu, S ; Pérez-Silanes, S ; Aldana, I ; Vivas, L ; Monge, A (MDPI AG, 2008-01-17)
    The aim of this study was to identify new compounds active against Plasmodium falciparum based on our previous research carried out on 3-phenyl-quinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives. Twelve compounds were synthesized and evaluated for antimalarial activity. Eight of them showed an IC(50) less than 1 microM against the 3D7 strain. Derivative 1 demonstrated high potency (IC(50)= 0.63 microM) and good selectivity (SI=10.35), thereby becoming a new lead-compound.