Pathology - Theses
Permanent URI for this collection
Search Results
1 - 2 of 2
-
ItemA novel depiction of genome variation data( 2006)The use of locus-specific databases for the storage and dispersal of genetic variation data has become the norm. The Human Genome Variation Society (formerly the HUGO Mutation Database Initiative) have led this field and produced a body of work to define standards for online variation databases. While these databases are available for all to access over the internet, they are often difficult to use and, particularly, to understand. Data presentation techniques and “fancy tools”1 for graphically displaying variation data are yet to receive the attention they deserve. This thesis looks at providing a system for use in a locus specific database, as a complement to an existing user interface, to quickly and easily produce graphical conceptual models of variation data in order to improve understanding by the database users.
-
ItemCharacterisation of axon glial interactions in the 2-50 transgenic mouse( 2006-12)The 2-50 transgenic mouse is a mutant containing the functional exons of human c-myc, an oncogene and cell cycle controller, under the control of the minimal sequence of the promoter of myelin basic protein, a component of the sheath surrounding axons of neurons. The transgene complex is expressed only in oligodendrocytes during a limited period of neonatal life, and is not detectable in large amounts. The animals suffer significant loss of oligodendrocyte precursor cells prior to myelination and onset of myelin formation is delayed. These animals elaborate only an incomplete myelin sheath in the central nervous system. Quantitative genetic analysis was used to characterize the transgene insertion and optic nerves from transgenic and non-transgenic animals were used for light and election microscopy, for electrophysiological testing and for immunohistochemical studies of glial cell subpopulations and axonal cytoskeletal components.