Pathology - Theses

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End date: 2006 × Type: Masters Research thesis ×

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    Some forensic aspects of chemical tests for alcohol
    Bayly, Ronald Cecil ( 1960)
    The problem surrounding the ever-increasing toll of death and injury arising from road accidents is one which is receiving increasing attention as the number of vehicles on the road continues to rise. While it has not been possible to isolate any one factor as the sole or even primary cause of road accidents, several surveys have shown that in many accidents alcohol has been a contributory factor by affecting the faculties of the driver of pedestrian. The thesis then goes on to discuss factors causing individual differences in response to the same blood alcohol concentration and the correlation between impairment of driving and blood alcohol concentration.
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    Functional and molecular changes of mitochondria in human aging: observations in dividing tissues
    Weng, Shan ( 2000)
    Studies in a number of human tissues have revealed that the activities of mitochondrial respiratory chain enzyme complexes decline during the aging process. Other studies have suggested that aging increases the frequency of mitochondrial DNA (mtDNA) mutation and leads to the accumulation of mutant mtDNA species, mainly those with large deletions and point mutations. Although the mitochondrial theory of aging may be more applicable to post mitotic tissues, abnormalities of mtDNA have also been reported in tissues which retain a mitotic capacity. Fresh tissues from elderly patients are difficult to obtain and only a limited number of studies on biochemical examination of respiratory chain enzyme complex activities have been carried out. Prostate tissue is readily available in elderly male subjects because of the high prevalence of benign prostatic hypertrophy in this sub-group of the population, and endoscopic surgery is routinely performed for excision of the diseased prostate. In this study, mitochondrial respiratory function and the mtDNA mutations in prostate tissues of elderly patients (aged from 56 to 92) were studied in 24 subjects. This included the measurement of the activities of the respiratory chain enzyme complexes and screening for mitochondrial point mutations and deletions at sites commonly affected in neurodegenerative diseases. (For complete summary open document)