Veterinary Clinical Sciences - Research Publications

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Author: Mansfield, Caroline × Author: Martinez Lopez, Lina × Author: Firestone, Simon ×

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    Changes in duodenal CD163-positive cells in dogs with chronic enteropathy after successful treatment
    Dandrieux, JRS ; Lopez, LMM ; Stent, A ; Jergens, A ; Allenspach, K ; Nowell, CJ ; Firestone, SM ; Kimpton, W ; Mansfield, CS (SAGE PUBLICATIONS LTD, 2018-10)
    Chronic enteropathy (CE) in dogs is characterized retrospectively per treatment response as food-responsive enteropathy (FRE), antibiotic-responsive enteropathy (ARE), and immunosuppressant-responsive enteropathy (IRE) - the latter most resembling inflammatory bowel disease in people. The aim of this study was to characterize duodenal macrophages (Mϕ) in CE using immunohistochemistry; with calprotectin (CAL) as a marker of early differentiated Mϕ and CD163 expression as a marker for resident Mϕ in the duodenum before and after treatment. Prior to treatment, dogs with FRE and IRE had a lower CD163+/CAL+ ratio than control dogs (CTRL) in crypts; this increased significantly and normalized compared with CTRL after treatment. Conversely, the CD163+/CAL+ ratio in dogs with ARE was comparable to that in healthy dogs before and after treatment. In summary, these results suggest that Mϕ play a role in the pathogenesis of CE in FRE and IRE, with a decrease in resident Mϕ and an increase in early differentiated Mϕ, but not in ARE dogs. Mϕ normalize after successful treatment.