Veterinary Clinical Sciences - Research Publications

Permanent URI for this collection

http://hdl.handle.net/11343/194098

Filters

2018 - 2019 3
3
Reset filters

Settings
Statistics
Citations
Author: Mansfield, Caroline × Author: Stent, Andrew ×

Search Results

Now showing 1 - 3 of 3
  • Item
    Thumbnail Image
    Emergence of nasal chondrosarcoma in a dog with nasal polyposis
    Sumner, JA ; Witham, AI ; Stent, AW ; Wightman, PF ; Mansfield, CS (WILEY, 2018-05)
    Whilst the malignant transformation of nasal polyps or secondary development of nasal neoplasia after chronic inflammation is likely to be relatively rare, this potential complication should be considered, and the clinician should be vigilant for evidence of malignant transformation.
  • Item
    Thumbnail Image
    Changes in duodenal CD163-positive cells in dogs with chronic enteropathy after successful treatment
    Dandrieux, JRS ; Lopez, LMM ; Stent, A ; Jergens, A ; Allenspach, K ; Nowell, CJ ; Firestone, SM ; Kimpton, W ; Mansfield, CS (SAGE PUBLICATIONS LTD, 2018-10)
    Chronic enteropathy (CE) in dogs is characterized retrospectively per treatment response as food-responsive enteropathy (FRE), antibiotic-responsive enteropathy (ARE), and immunosuppressant-responsive enteropathy (IRE) - the latter most resembling inflammatory bowel disease in people. The aim of this study was to characterize duodenal macrophages (Mϕ) in CE using immunohistochemistry; with calprotectin (CAL) as a marker of early differentiated Mϕ and CD163 expression as a marker for resident Mϕ in the duodenum before and after treatment. Prior to treatment, dogs with FRE and IRE had a lower CD163+/CAL+ ratio than control dogs (CTRL) in crypts; this increased significantly and normalized compared with CTRL after treatment. Conversely, the CD163+/CAL+ ratio in dogs with ARE was comparable to that in healthy dogs before and after treatment. In summary, these results suggest that Mϕ play a role in the pathogenesis of CE in FRE and IRE, with a decrease in resident Mϕ and an increase in early differentiated Mϕ, but not in ARE dogs. Mϕ normalize after successful treatment.
  • Item
    Thumbnail Image
    Toxoplasmosis as a cause of life-threatening respiratory distress in a dog receiving immunosuppressive therapy
    Pepper, A ; Mansfield, C ; Stent, A ; Johnstone, T (WILEY, 2019-05-01)
    Disseminated toxoplasmosis is a potentially fatal complication in dogs receiving immunosuppressive therapy, particularly if multiple immunosuppressive drugs are used. Toxoplasmosis should be considered if signs of acute respiratory or hepatic disease develop, and diagnosis would rely on demonstration of organisms via cytology or PCR rather than a single time-point serological assay.