Melbourne School of Psychological Sciences - Research Publications

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Author: Buckley, Rachel × Author: Eratne, Dhamidhu × End date: 2024 × Start date: 2020 × Type: Journal Article ×

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    Short sleep duration is associated with lower cerebrospinal fluid amyloid beta 42 levels in midlife: a preliminary report
    Gibson, M ; Nicolazzo, J ; Cavuoto, M ; Rowsthorn, E ; Cribb, L ; Bransby, L ; Buckley, R ; Yassi, N ; Yiallourou, S ; Brodtmann, A ; Velakoulis, D ; Eratne, D ; Hamilton, GS ; Naughton, MT ; Lim, YY ; Pase, MP (OXFORD UNIV PRESS INC, 2023-04-12)
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    CSF Aβ42 and tau biomarkers in cognitively unimpaired Aβ- middle-aged and older APOE ε4 carriers
    Lim, YY ; Yassi, N ; Bransby, L ; Ayton, S ; Buckley, RF ; Eratne, D ; Velakoulis, D ; Li, Q-X ; Fowler, C ; Masters, CL ; Maruff, P (ELSEVIER SCIENCE INC, 2023-09)
    This study aimed to determine the relationship between the apolipoprotein E (APOE) ε4 allele and cerebrospinal fluid (CSF) and neuroimaging biomarkers of Alzheimer's disease, and cognition in cognitively unimpaired (CU) middle-aged adults (n = 82; Mage = 58.2), and in Aβ- CU older adults (n = 71; Mage = 71.8). Aβ- CU middle-aged ε4 carriers showed lower CSF Aβ42 levels, higher levels of CSF total tau (t-tau) and neurofilament light (NfL), and poorer cognitive performance compared to noncarriers (Cohen's d: 0.30-0.56). In Aβ- CU older adults, ε4 carriers also had lower CSF Aβ42 levels and higher levels of CSF t-tau and p-tau181, compared to noncarriers (Cohen's d: 0.65-0.74). In both Aβ- middle-aged and older adults, hippocampal and total brain volume were equivalent between ε4 carriers and noncarriers. In Aβ- CU middle-aged adults, APOE ε4 is associated with decreased levels of Aβ, increased tau and NfL, and poorer cognition. Similar relationships were observed in Aβ- CU older adults. These results have implications for understanding clinicopathological relationships between APOE ε4 and the emergence of cognitive and biomarker abnormalities in Aβ- adults.