Infectious Diseases - Research Publications

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Author: De Luca, Joseph × Author: Vogrin, Sara × Start date: 2010 ×

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    Phenotypic distribution and tolerability of re-vaccination in individuals with delayed hypersensitivity to COVID-19 vaccines
    De Luca, J ; Awad, A ; Vogrin, S ; Waldron, J ; Douglas, A ; Chua, K ; Holmes, N ; Trubiano, J (MOSBY-ELSEVIER, 2023-02)
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    The Who, What, When, and Where of Inpatient Direct Oral Penicillin Challenge-Implications for Health Services Implementation
    Trubiano, JA ; Vogrin, S ; Mitri, E ; Hall, R ; Copaescu, A ; Waldron, J ; De Luca, J ; Rose, M ; Mackay, G ; Lambros, B ; Douglas, AP ; Holmes, NE ; Chua, KYL (OXFORD UNIV PRESS INC, 2023-07-05)
    Inpatient direct oral challenge programs are increasingly deployed as part of antimicrobial stewardship initiatives to reduce the burden and impacts of penicillin allergy labels on antibiotic prescribing. Using data from a prospective, multicenter cohort inpatient penicillin allergy program, we identify the key targets for delabeling to aid health service implementation.
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    Study protocol: Australasian Registry of Severe Cutaneous Adverse Reactions (AUS-SCAR)
    James, F ; Goh, MSY ; Mouhtouris, E ; Vogrin, S ; Chua, KYL ; Holmes, NE ; Awad, A ; Copaescu, A-M ; De Luca, JF ; Zubrinich, C ; Gin, D ; Cleland, H ; Douglas, A ; Kern, JS ; Katelaris, CH ; Thien, F ; Barnes, S ; Yun, J ; Tong, W ; Smith, WB ; Carr, A ; Anderson, T ; Legg, A ; Bourke, J ; Mackay, LK ; Aung, AK ; Phillips, EJ ; Trubiano, J (BMJ PUBLISHING GROUP, 2022-08)
    INTRODUCTION: Severe cutaneous adverse reactions (SCAR) are a group of T cell-mediated hypersensitivities associated with significant morbidity, mortality and hospital costs. Clinical phenotypes include Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS) and acute generalised exanthematous pustulosis (AGEP). In this Australasian, multicentre, prospective registry, we plan to examine the clinical presentation, drug causality, genomic predictors, potential diagnostic approaches, treatments and long-term outcomes of SCAR in Australia and New Zealand. METHODS AND ANALYSIS: Adult and adolescent patients with SCAR including SJS, TEN, DRESS, AGEP and another T cell-mediated hypersensitivity, generalised bullous fixed drug eruption, will be prospectively recruited. A waiver of consent has been granted for some sites to retrospectively include cases which result in early mortality. DNA will be collected for all prospective cases. Blood, blister fluid and skin biopsy sampling is optional and subject to patient consent and site capacity. To develop culprit drug identification and prevention, genomic testing will be performed to confirm human leukocyte antigen (HLA) type and ex vivo testing will be performed via interferon-γ release enzyme linked immunospot assay using collected peripheral blood mononuclear cells. The long-term outcomes of SCAR will be investigated with a 12-month quality of life survey and examination of prescribing and mortality data. ETHICS AND DISSEMINATION: This study was reviewed and approved by the Austin Health Human Research Ethics Committee (HREC/50791/Austin-19). Results will be published in peer-reviewed journals and presented at relevant conferences. TRIAL REGISTRATION NUMBER: Australian New Zealand Clinical Trials Registry (ACTRN12619000241134).