Bio21 - Research Publications

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Skeletal Muscle Insulin Resistance Associated with Cholesterol-Induced Activation of Macrophages Is Prevented by High Density Lipoprotein

Carey, AL ; Siebel, AL ; Reddy-Luthmoodoo, M ; Natoli, AK ; D'Souza, W ; Meikle, PJ ; Sviridov, D ; Drew, BG ; Kingwell, BA ; Kanzaki, M (PUBLIC LIBRARY SCIENCE, 2013-02-21)

Emerging evidence suggests that high density lipoprotein (HDL) may modulate glucose metabolism through multiple mechanisms including pancreatic insulin secretion as well as insulin-independent glucose uptake into muscle. We hypothesized that HDL may also increase skeletal muscle insulin sensitivity via cholesterol removal and anti-inflammatory actions in macrophages associated with excess adiposity and ectopic lipid deposition.