Bio21 - Research Publications

Permanent URI for this collection

Now showing 1 - 1 of 1

B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals.

Loder, F ; Mutschler, B ; Ray, RJ ; Paige, CJ ; Sideras, P ; Torres, R ; Lamers, MC ; Carsetti, R (Rockefeller University Press, 1999-07-05)

Only mature B lymphocytes can enter the lymphoid follicles of spleen and lymph nodes and thus efficiently participate in the immune response. Mature, long-lived B lymphocytes derive from short-lived precursors generated in the bone marrow. We show that selection into the mature pool is an active process and takes place in the spleen. Two populations of splenic B cells were identified as precursors for mature B cells. Transitional B cells of type 1 (T1) are recent immigrants from the bone marrow. They develop into the transitional B cells of type 2 (T2), which are cycling and found exclusively in the primary follicles of the spleen. Mature B cells can be generated from T1 or T2 B cells. Mice with genetic deletions of elements participating in the B cell receptor signaling cascade display developmental arrest at the T1 or T2 stage. The analysis of these defects showed that the development of T2 and mature B cells from T1 precursors requires defined qualitative and quantitative signals derived from the B cell receptor and that the induction of longevity and maturation requires different signals.