Radiology - Research Publications

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Author: Ames, David Ɨ Author: Desmond, Patricia Ɨ Author: Lautenschlager, Nicola Ɨ End date: 2019 Ɨ Start date: 2015 Ɨ Type: Journal Article Ɨ

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    Alterations in dorsal and ventral posterior cingulate connectivity in APOE Īµ4 carriers at risk of Alzheimer's disease
    Kerestes, R ; Phal, PM ; Steward, C ; Moffat, BA ; Salinas, S ; Cox, KL ; Ellis, KA ; Cyarto, EV ; Ames, D ; Martins, RN ; Masters, CL ; Rowe, CC ; Sharman, MJ ; Salvado, O ; Szoeke, C ; Lai, M ; Lautenschlager, NT ; Desmond, PM (ROYAL COLL PSYCHIATRISTS, 2015-10)
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    A Randomized Controlled Trial of Adherence to a 24-Month Home-Based Physical Activity Program and the Health Benefits for Older Adults at Risk of Alzheimer's Disease: The AIBL Active-Study
    Cox, KL ; Cyarto, E ; Ellis, KA ; Ames, D ; Desmond, P ; Phal, P ; Sharman, MJ ; Szoeke, C ; Rowe, CC ; Masters, CL ; You, E ; Burrows, S ; Lai, MMY ; Lautenschlager, NT ; Anstey, K ; Peters, R (IOS PRESS, 2019)
    BACKGROUND: Previous studies have demonstrated that physical activity (PA) interventions can improve physical and cognitive outcomes in older adults, but most have been relatively short in duration (<1 year) with a few having specifically targeting individuals at risk of developing Alzheimer's disease. OBJECTIVE: To examine adherence and physical health outcomes in a 24-month home-based PA intervention in older adults at risk of Alzheimer's disease. METHODS: Participants 60 years and older with mild cognitive impairment (MCI) or subjective memory complaints (SMC) with at least 1 cerebrovascular risk factor recruited from The Australian Imaging Biomarkers and Lifestyle Flagship Study of Aging (AIBL) were randomized to a PA or control group (nā€Š=ā€Š106). The control group continued with their usual lifestyle. The PA group received a 24-month home-based program with a target of 150 minutes/week of moderate PA and a behavioral intervention. Retention (participants remaining) and PA adherence (PA group only, percent PA completed to the PA prescribed) were determined at 6, 12, 18, and 24 months. Assessments at baseline, 6, 12, and 24 months included, PA; fitness; body composition and fat distribution. Key outcome measures were PA adherence and PA. RESULTS: The 24-month retention rate (97.2%) and the median PA adherence 91.67% (Q1-Q3, 81.96, 100.00) were excellent. In the long-term the intervention group achieved significantly better improvements in PA levels, leg strength, fat mass and fat distribution compared to the control. CONCLUSION: This study demonstrates that in this target group, long-term PA adherence is achievable and has physical health benefits.