Radiology - Research Publications

Permanent URI for this collection

http://hdl.handle.net/11343/196

Filters

2012 2
Reset filters

Settings
Statistics
Citations
Start date: 2012 × Type: Journal Article × End date: 2012 × Author: Ackerman, Ilana ×

Search Results

Now showing 1 - 2 of 2
  • Item
    No Preview Available
    Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
    Vos, T ; Flaxman, AD ; Naghavi, M ; Lozano, R ; Michaud, C ; Ezzati, M ; Shibuya, K ; Salomon, JA ; Abdalla, S ; Aboyans, V ; Abraham, J ; Ackerman, I ; Aggarwal, R ; Ahn, SY ; Ali, MK ; Alvarado, M ; Anderson, HR ; Anderson, LM ; Andrews, KG ; Atkinson, C ; Baddour, LM ; Bahalim, AN ; Barker-Collo, S ; Barrero, LH ; Bartels, DH ; Basanez, M-G ; Baxter, A ; Bell, ML ; Benjamin, EJ ; Bennett, D ; Bernabe, E ; Bhalla, K ; Bhandari, B ; Bikbov, B ; Bin Abdulhak, A ; Birbeck, G ; Black, JA ; Blencowe, H ; Blore, JD ; Blyth, F ; Bolliger, I ; Bonaventure, A ; Boufous, SA ; Bourne, R ; Boussinesq, M ; Braithwaite, T ; Brayne, C ; Bridgett, L ; Brooker, S ; Brooks, P ; Brugha, TS ; Bryan-Hancock, C ; Bucello, C ; Buchbinder, R ; Buckle, GR ; Budke, CM ; Burch, M ; Burney, P ; Burstein, R ; Calabria, B ; Campbell, B ; Canter, CE ; Carabin, H ; Carapetis, J ; Carmona, L ; Cella, C ; Charlson, F ; Chen, H ; Cheng, AT-A ; Chou, D ; Chugh, SS ; Coffeng, LE ; Colan, SD ; Colquhoun, S ; Colson, KE ; Condon, J ; Connor, MD ; Cooper, LT ; Corriere, M ; Cortinovis, M ; de Vaccaro, KC ; Couser, W ; Cowie, BC ; Criqui, MH ; Cross, M ; Dabhadkar, KC ; Dahiya, M ; Dahodwala, N ; Damsere-Derry, J ; Danaei, G ; Davis, A ; De Leo, D ; Degenhardt, L ; Dellavalle, R ; Delossantos, A ; Denenberg, J ; Derrett, S ; Des Jarlais, DC ; Dharmaratne, SD ; Dherani, M ; Diaz-Torne, C ; Dolk, H ; Dorsey, ER ; Driscoll, T ; Duber, H ; Ebel, B ; Edmond, K ; Elbaz, A ; Ali, SE ; Erskine, H ; Erwin, PJ ; Espindola, P ; Ewoigbokhan, SE ; Farzadfar, F ; Feigin, V ; Felson, DT ; Ferrari, A ; Ferri, CP ; Fevre, EM ; Finucane, MM ; Flaxman, S ; Flood, L ; Foreman, K ; Forouzanfar, MH ; Fowkes, FGR ; Franklin, R ; Fransen, M ; Freeman, MK ; Gabbe, BJ ; Gabriel, SE ; Gakidou, E ; Ganatra, HA ; Garcia, B ; Gaspari, F ; Gillum, RF ; Gmel, G ; Gosselin, R ; Grainger, R ; Groeger, J ; Guillemin, F ; Gunnell, D ; Gupta, R ; Haagsma, J ; Hagan, H ; Halasa, YA ; Hall, W ; Haring, D ; Maria Haro, J ; Harrison, JE ; Havmoeller, R ; Hay, RJ ; Higashi, H ; Hill, C ; Hoen, B ; Hoffman, H ; Hotez, PJ ; Hoy, D ; Huang, JJ ; Ibeanusi, SE ; Jacobsen, KH ; James, SL ; Jarvis, D ; Jasrasaria, R ; Jayaraman, S ; Johns, N ; Jonas, JB ; Karthikeyan, G ; Kassebaum, N ; Kawakami, N ; Keren, A ; Khoo, J-P ; King, CH ; Knowlton, LM ; Kobusingye, O ; Koranteng, A ; Krishnamurthi, R ; Lalloo, R ; Laslett, LL ; Lathlean, T ; Leasher, JL ; Lee, YY ; Leigh, J ; Lim, SS ; Limb, E ; Lin, JK ; Lipnick, M ; Lipshultz, SE ; Liu, W ; Loane, M ; Ohno, SL ; Lyons, R ; Ma, J ; Mabweijano, J ; MacIntyre, MF ; Malekzadeh, R ; Mallinger, L ; Manivannan, S ; Marcenes, W ; March, L ; Margolis, DJ ; Marks, GB ; Marks, R ; Matsumori, A ; Matzopoulos, R ; Mayosi, BM ; McAnulty, JH ; McDermott, MM ; McGill, N ; McGrath, J ; Elena Medina-Mora, M ; Meltzer, M ; Mensah, GA ; Merriman, TR ; Meyer, A-C ; Miglioli, V ; Miller, M ; Miller, TR ; Mitchell, PB ; Mocumbi, AO ; Moffitt, TE ; Mokdad, AA ; Monasta, L ; Montico, M ; Moradi-Lakeh, M ; Moran, A ; Morawska, L ; Mori, R ; Murdoch, ME ; Mwaniki, MK ; Naidoo, K ; Nair, MN ; Naldi, L ; Narayan, KMV ; Nelson, PK ; Nelson, RG ; Nevitt, MC ; Newton, CR ; Nolte, S ; Norman, P ; Norman, R ; O'Donnell, M ; O'Hanlon, S ; Olives, C ; Omer, SB ; Ortblad, K ; Osborne, R ; Ozgediz, D ; Page, A ; Pahari, B ; Pandian, JD ; Rivero, AP ; Patten, SB ; Pearce, N ; Perez Padilla, R ; Perez-Ruiz, F ; Perico, N ; Pesudovs, K ; Phillips, D ; Phillips, MR ; Pierce, K ; Pion, S ; Polanczyk, GV ; Polinder, S ; Pope, CA ; Popova, S ; Porrini, E ; Pourmalek, F ; Prince, M ; Pullan, RL ; Ramaiah, KD ; Ranganathan, D ; Razavi, H ; Regan, M ; Rehm, JT ; Rein, DB ; Remuzzi, G ; Richardson, K ; Rivara, FP ; Roberts, T ; Robinson, C ; De Leon, FR ; Ronfani, L ; Room, R ; Rosenfeld, LC ; Rushton, L ; Sacco, RL ; Saha, S ; Sampson, U ; Sanchez-Riera, L ; Sanman, E ; Schwebel, DC ; Scott, JG ; Segui-Gomez, M ; Shahraz, S ; Shepard, DS ; Shin, H ; Shivakoti, R ; Singh, D ; Singh, GM ; Singh, JA ; Singleton, J ; Sleet, DA ; Sliwa, K ; Smith, E ; Smith, JL ; Stapelberg, NJC ; Steer, A ; Steiner, T ; Stolk, WA ; Stovner, LJ ; Sudfeld, C ; Syed, S ; Tamburlini, G ; Tavakkoli, M ; Taylor, HR ; Taylor, JA ; Taylor, WJ ; Thomas, B ; Thomson, WM ; Thurston, GD ; Tleyjeh, IM ; Tonelli, M ; Towbin, JRA ; Truelsen, T ; Tsilimbaris, MK ; Ubeda, C ; Undurraga, EA ; van der Werf, MJ ; van Os, J ; Vavilala, MS ; Venketasubramanian, N ; Wang, M ; Wang, W ; Watt, K ; Weatherall, DJ ; Weinstock, MA ; Weintraub, R ; Weisskopf, MG ; Weissman, MM ; White, RA ; Whiteford, H ; Wiersma, ST ; Wilkinson, JD ; Williams, HC ; Williams, SRM ; Witt, E ; Wolfe, F ; Woolf, AD ; Wulf, S ; Yeh, P-H ; Zaidi, AKM ; Zheng, Z-J ; Zonies, D ; Lopez, AD ; Murray, CJL (ELSEVIER SCIENCE INC, 2012-12-15)
    BACKGROUND: Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs). METHODS: Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis. FINDINGS: Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350,000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient -0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa. INTERPRETATION: Rates of YLDs per 100,000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world. FUNDING: Bill & Melinda Gates Foundation.
  • Item
    No Preview Available
    Challenges in Evaluating an Arthritis Self-management Program for People with Hip and Knee Osteoarthritis in Real-world Clinical Settings
    Ackerman, IN ; Buchbinder, R ; Osborne, RH (J RHEUMATOL PUBL CO, 2012-05)
    OBJECTIVE: To evaluate the influence of a 6-week Arthritis Self-Management Program (ASMP) on health-related quality of life (HRQOL) and self-management skills in clinical settings. METHODS: Individuals with hip or knee osteoarthritis referred to orthopedic surgeons or rheumatologists at 6 hospitals in Victoria, Australia, were recruited. In a randomized controlled trial, participants received the Stanford ASMP and self-help book (intervention) or book only (control). Assessments included the Assessment of Quality of Life instrument (AQoL; range -0.04 to 1.00) and Health Education Impact Questionnaire (heiQ; range 1-6) at baseline and up to 12 months. The primary outcome was HRQOL at 12 months (assessed using the AQoL). RESULTS: Recruitment was concluded early due to persistent challenges including infrequent referrals and patient inability or disinterest in participating. Of 1125 individuals screened, only 120 were randomized (control, n = 62; intervention, n = 58). Seven ASMP were conducted while 18 scheduled ASMP were cancelled. Forty-four of 58 intervention group participants received the intervention as allocated (76%); all control group participants were sent the book (100%). Ninety-four participants (78%) completed 12-month assessments (control, 90%; intervention, 66%). There was no difference in HRQOL at 12 months (adjusted mean difference -0.02, 95% CI -0.09 to 0.05). At 6 weeks, the intervention group reported higher heiQ skill and technique acquisition scores (adjusted mean difference 0.29, 95% CI 0.04 to 0.55); however, this dissipated by 3 months. CONCLUSION: Significant challenges hampered this evaluation of the ASMP. The observed lack of enthusiasm from potential referrers and patients raises doubts about the practicality of this intervention in real-world settings. (ANZCTR Clinical Trials Registry no. ACTRN12606000174583).