Sir Peter MacCallum Department of Oncology - Research Publications

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Author: Gorringe, Kylie × End date: 2009 × Start date: 2000 ×

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    Molecular cytogenetic analysis of breast cancer cell lines
    Davidson, JM ; Gorringe, KL ; Chin, SF ; Orsetti, B ; Besret, C ; Courtay-Cahen, C ; Roberts, I ; Theillet, C ; Caldas, C ; Edwards, PAW (CHURCHILL LIVINGSTONE, 2000-11)
    The extensive chromosome rearrangements of breast carcinomas must contribute to tumour development, but have been largely intractable to classical cytogenetic banding. We report here the analysis by 24-colour karyotyping and comparative genomic hybridization (CGH) of 19 breast carcinoma cell lines and one normal breast epithelial cell line, which provide model examples of karyotype patterns and translocations present in breast carcinomas. The CGH was compared with CGH of 106 primary breast cancers. The lines varied from perfectly diploid to highly aneuploid. Translocations were very varied and over 98% were unbalanced. The most frequent in the carcinomas were 8;11 in five lines; and 8;17, 1;4 and 1;10 in four lines. The most frequently involved chromosome was 8. Several lines showed complex multiply-translocated chromosomes. The very aneuploid karyotypes appeared to fall into two groups that evolved by different routes: one that steadily lost chromosomes and at one point doubled their entire karyotype; and another that steadily gained chromosomes, together with abnormalities. All karyotypes fell within the range seen in fresh material and CGH confirmed that the lines were broadly representative of fresh tumours. The karyotypes provide a resource for the cataloguing and analysis of translocations in these tumours, accessible at http://www.path.cam.ac.uk/ approximately pawefish.
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    A rational approach to cancer therapy.
    Gorringe, KL ; Campbell, IG (Springer Science and Business Media LLC, 2008)
    A report on the 20th Annual Lorne Cancer Conference, Lorne, Australia, 14-16 February 2008.
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    Gender Differences in Publication Output: Towards an Unbiased Metric of Research Performance
    Symonds, MRE ; Gemmell, NJ ; Braisher, TL ; Gorringe, KL ; Elgar, MA ; Tregenza, T (PUBLIC LIBRARY SCIENCE, 2006-12-27)
    We examined the publication records of a cohort of 168 life scientists in the field of ecology and evolutionary biology to assess gender differences in research performance. Clear discrepancies in publication rate between men and women appear very early in their careers and this has consequences for the subsequent citation of their work. We show that a recently proposed index designed to rank scientists fairly is in fact strongly biased against female researchers, and advocate a modified index to assess men and women on a more equitable basis.