Sir Peter MacCallum Department of Oncology - Research Publications

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Author: McArthur, Grant × Subject: checkpoint ×

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    BRAF-targeted therapy and immune responses to melanoma
    Ngiow, SF ; Knight, DA ; Ribas, A ; McArthur, GA ; Smyth, MJ (LANDES BIOSCIENCE, 2013-06-01)
    Type I BRAF inhibitors and immunotherapy constitute two new exciting approaches for the treatment of advanced malignant melanoma. We have recently elucidated a role for host C-C chemokine receptor type 2 (CCR2) in the antineoplastic effects of type I BRAF inhibitors in mice, supporting the therapeutic potential of combining BRAF inhibitors with immunotherapy.