Sir Peter MacCallum Department of Oncology - Research Publications

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End date: 2013 × Author: Beavis, Paul × Author: MILENKOVSKI, NICOLE ×

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    A2A blockade enhances anti-metastatic immune responses
    Beavis, PA ; Milenkovski, N ; Stagg, J ; Smyth, MJ ; Darcy, PK (TAYLOR & FRANCIS INC, 2013-12)
    The specific targeting of tumor-elicited immunosuppression is a promising strategy for the treatment of cancer. We have recently demonstrated that targeting the immunosuppressive pathway mediated by CD73-derived adenosine through the blockade of A2A/A2B adenosine receptors significantly reduced the metastatic potential of CD73+ breast carcinomas and melanomas via both immunological and non-immunological mechanisms.