Sir Peter MacCallum Department of Oncology - Research Publications

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Start date: 2013 × End date: 2013 × Author: SMYTH, MARK × Author: ANDREWS, DANIEL × Type: Journal Article ×

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    Non-classical MHC Class I molecules regulating natural killer cell function
    Smyth, MJ ; Sullivan, LC ; Brooks, AG ; Andrews, DM (TAYLOR & FRANCIS INC, 2013-03-01)
    Natural killer (NK) cells possess effector and immunoregulatory functions that are controlled by a myriad of receptor-ligand pairs, including human killer inhibitory receptor (KIR) and mouse Ly49-MHC class I interactions. We have recently shown that the NK cell inhibitory molecule Ly49A binds the non-classical MHC molecule H2-M3, thus regulating host innate immune responses to tumor initiation and metastasis.