Sir Peter MacCallum Department of Oncology - Research Publications

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Type: Journal Article × Start date: 2000 × End date: 2009 × Author: MacManus, Michael × Author: Ball, David ×

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    A phase I trial of high-dose palliative radiotherapy plus concurrent weekly Vinorelbine and Cisplatin in patients with locally advanced and metastatic NSCLC
    Michael, M ; Wirth, A ; Ball, DL ; MacManus, M ; Rischin, D ; Mileshkin, L ; Solomon, B ; McKendrick, J ; Milner, AD (NATURE PUBLISHING GROUP, 2005-09-19)
    The role of concurrent chemoradiotherapy (CRT) in patients with non-small-cell lung cancer (NSCLC) unsuitable for radical therapy but who require locoregional treatment has not been defined. The aims of this phase I trial were thus to develop a novel regimen of weekly chemotherapy concurrent with high-dose palliative RT (40 Gy/20 fractions) and assess its tolerability, objective and symptomatic response rates. Eligible patients had stage I-IIIB NSCLC unsuitable for radical RT or limited stage IV disease, ECOG PS