Surgery (Austin & Northern Health) - Research Publications

Permanent URI for this collection

Search Results

Now showing 1 - 3 of 3
  • Item
    Thumbnail Image
    SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study
    Li, E (WILEY, 2022-01)
    SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS-CoV-2 diagnosis was defined as peri-operative (7 days before to 30 days after surgery); recent (1-6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS-CoV-2; 2.2% (50/2317) in patients with peri-operative SARS-CoV-2; 1.6% (15/953) in patients with recent SARS-CoV-2; and 1.0% (11/1148) in patients with previous SARS-CoV-2. After adjustment for confounding factors, patients with peri-operative (adjusted odds ratio 1.5 (95%CI 1.1-2.0)) and recent SARS-CoV-2 (1.9 (95%CI 1.2-3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS-CoV-2 (1.7 (95%CI 0.9-3.0)). Overall, venous thromboembolism was independently associated with 30-day mortality (5.4 (95%CI 4.3-6.7)). In patients with SARS-CoV-2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri-operative or recent SARS-CoV-2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of SARS-CoV-2 infection. Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly.
  • Item
    No Preview Available
    SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study
    Nepogodiev, D ; Bhangu, A (OXFORD UNIV PRESS, 2021-09-27)
    BACKGROUND: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. METHODS: The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. RESULTS: NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year. CONCLUSION: As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population.
  • Item
    Thumbnail Image
    Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study
    Simoes, JFF ; Nepogodiev, D ; Ademuyiwa, A ; Buarque, I ; El-Boghdadly, K ; Gebreyohanes, M ; Glasbey, JC ; Kronberger, E ; Kruijff, S ; Li, E ; Loeffler, M ; Mashbari, H ; Pata, F ; Smart, N ; Sayyed, R ; Shu, S ; Sund, M ; Bhangu, A ; Simoes, J ; Ahmed, W-U-R ; Argus, L ; Ball, A ; Bhangu, A ; Bywater, EP ; Blanco-Colino, R ; Brar, A ; Chaudhry, D ; Dawson, BE ; Duran, I ; Elhadi, M ; Glasbey, JC ; Gujjuri, RR ; Jones, CS ; Harrison, EM ; Kamarajah, SK ; Keatley, JM ; Lawday, S ; Li, E ; Mann, H ; Marson, EJ ; Mclean, KA ; Nepogodiev, D ; Norman, L ; Ots, R ; Outani, O ; Picciochi, M ; Santos, I ; Shaw, C ; Simoes, JFF ; Taylor, EH ; Trout, IM ; Varghese, C ; Venn, ML ; Xu, W ; Dajti, I ; Gjata, A ; Kacimi, SEO ; Boccalatte, L ; Cox, D ; Pockney, P ; Townend, P ; Aigner, F ; Kronberger, IE ; Samadov, E ; Alderazi, A ; Hossain, K ; Padmore, G ; van Ramshorst, G ; Lawani, I ; Cerovac, A ; Delibegovic, S ; Baiocchi, G ; Ataide Gomes, GM ; Buarque, IL ; Gohar, M ; Slavchev, M ; Nwegbu, C ; Agarwal, A ; Brar, A ; Martin, J ; Ng-Kamstra, J ; Marta Modolo, M ; Olivos, M ; Lou, W ; Ren, D-L ; Andres Calvache, J ; Rivera, CJ-P ; Hadzibegovic, AD ; Kopjar, T ; Mihanovic, J ; Aviles Jimenez, PM ; Gouvas, N ; Klat, J ; Novysedlak, R ; Amisi, N ; Christensen, P ; El-Hussuna, A ; Batista, S ; Lincango-Naranjo, E ; Emile, S ; Arevalo Sandoval, DA ; Dhufera, H ; Hailu, S ; Mengesha, MG ; Kauppila, JH ; Arnaud, AP ; Demetrashvili, Z ; Albertsmeier, M ; Lederhuber, H ; Loeffler, MW ; Acquah, DK ; Ofori, B ; Tabiri, S ; Metallidis, S ; Tsoulfas, G ; Aguilera-Arevalo, M-L ; Recinos, G ; Mersich, T ; Wettstein, D ; Ghosh, D ; Kembuan, G ; Milan, PB ; Khosravi, MH ; Mozafari, M ; Hilmi, A ; Mohan, H ; Zmora, O ; Gallo, G ; Pata, F ; Pellino, G ; Fujimoto, Y ; Kuroda, N ; Satoi, S ; Abou Chaar, MK ; Ayasra, F ; Fakhradiyev, I ; Hamdun, IHS ; Jin-Young, J ; Jamal, M ; Karout, L ; Elhadi, M ; Gulla, A ; Rasoaherinomenjanahary, F ; Samison, LH ; Roslani, AC ; Duran Sanchez, II ; Samantha Gonzalez, D ; Martinez, L ; Jose Martinez, M ; Nayen, A ; Ramos-De la Medina, A ; Nunez, J ; Outani, O ; Nashidengo, PR ; Shah, R ; Shrestha, AL ; Jonker, P ; Kruijff, S ; Noltes, M ; Steinkamp, P ; Varghese, C ; Wright, D ; Abdur-Rahman, L ; Ademuyiwa, A ; Adisa, A ; Osinaike, B ; Seyi-Olajide, J ; Williams, O ; Williams, E ; Pejkova, S ; Al Balushi, Z ; Qureshi, AU ; Sayyed, R ; Mohsen, MA ; Abukhalaf, SA ; Cukier, M ; Gomez-Fernandez, H ; Shu Yip, S ; Vasquez Ojeda, XP ; Dione Sacdalan, M ; Major, P ; Azevedo, J ; Cunha, MF ; Santos, I ; Zarour, A ; Bonci, E-A ; Negoi, I ; Efetov, S ; Kochetkov, V ; Litvin, A ; Ingabire, JA ; Bucyibaruta, G ; Faustin, N ; Habumuremyi, S ; Imanishimwe, A ; de Dieu, HJ ; Munyaneza, E ; Ncogoza, I ; Alameer, E ; Ndong, A ; Radenkovic, D ; Chew, MH ; Koh, F ; Ngu, J ; Panyko, A ; Bele, U ; Kosir, JA ; Daoud, H ; Blanco-Colino, R ; Minaya Bravo, AM ; Jayarajah, U ; Wickramasinghe, D ; Adam, MEAE ; Rutegard, M ; Sund, M ; Adamina, M ; Gialamas, E ; Horisberger, K ; Alshaar, M ; Huang, A ; Lohsiriwat, V ; Charles, S ; Jlassi, H ; Isik, A ; Leventoglu, S ; Lekuya, HM ; Lule, H ; Kopetskyi, S ; Alsaadi, H ; Alshryda, S ; Alser, O ; Bankhead-Kendall, B ; Breen, K ; Kaafarani, H ; Mashbari, H ; Cal, FB ; Al-Naggar, H ; Maimbo, M ; Mazingi, D ; Abbott, T ; Adamina, M ; Akhbari, M ; Benson, R ; Bhanderi, S ; Biccard, B ; Caruana, E ; Chakrabortee, S ; Chapatwala, R ; Costas-Chavarri, A ; Demetriades, AK ; Desai, A ; Di Saverio, S ; Drake, T ; Edwards, J ; Evans, J ; Fiore, M ; Ford, S ; Fotopoulou, C ; Fowler, A ; Futaba, K ; Ganly, I ; James, HG ; Griffiths, E ; Gronchi, A ; Hutchinson, P ; Hyman, GY ; Incorvia, J ; Jain, R ; Jenkinson, M ; Khan, T ; Knight, SR ; Kolias, A ; Kudsk-Iversen, S ; Kwan, TY ; Leung, E ; Mayol, J ; McKay, S ; Meara, JG ; Mills, E ; Moug, S ; Patel, A ; Perinotti, R ; Rice, HE ; Roberts, K ; Schache, A ; Shaw, R ; Smart, N ; Stephens, M ; Stewart, GD ; Teasdale, E ; Vaughan-Shaw, P ; Vidya, R ; Wright, N ; Wuraola, F ; Zimmelman, N ; Agastra, E ; Thereska, D ; Martin Lucchini, S ; Laudani, V ; Boccalatte, L ; Chwat, C ; Pedraza Salazar, II ; Pantoja Pachajoa, DA ; Duro, A ; Calderon Arancibia, JA ; Cox, D ; D'Aulerio, G ; Dudi-Venkata, N ; Egoroff, N ; Farik, S ; Lott, N ; Moss, J-L ; Pockney, P ; Rennie, S ; Tan, L ; Varghese, C ; Vo, UG ; Watson, D ; Watters, D ; Wright, D ; Bright, T ; Hollington, P ; Zhou, X ; Kroon, HM ; Farfus, A ; Barker, J ; Watson, E ; Stevens, S ; Latif, H ; Dawson, AC ; Chuan, A ; Muralidharan, V ; Wong, E ; Ackermann, T ; Pacilli, M ; Hodgson, R ; Heriot, A ; Choong, P ; Brown, W ; Lidder, S ; Yeung, J ; Traeger, L ; Regalo, G ; Gourlay, R ; Pockney, P ; Badiani, S ; Koh, C ; Putnis, S ; Dawson, AC ; Haider, F ; Mitul, AR ; Komen, N ; Dhondt, B ; Cappeliez, S ; Pigeolet, M ; van Ramshorst, G ; Schoneveld, M ; Stijns, J ; Oosterlinck, W ; Flamey, N ; Kpangon, C ; Agbadebo, M ; Tobome, SR ; Cerovac, A ; Barros, AV ; Aguiar Junior, S ; Baiocchi, G ; do Amaral Campos, HG ; Gross, J ; Fernandez Coimbra, FJ ; Kowalski, LP ; Makdissi, F ; Nakagawa, S ; Duprat Neto, JP ; Vartanian, JG ; Yazbek, G ; Zequi, SC ; Flumignan, R ; Slavchev, M ; Jaworska, N ; Dell, A ; Shanthanna, H ; Martin, J ; Behzadi, A ; Nessim, C ; Mozel, M ; St-germain, P ; Russell, C ; Groot, G ; Safieddine, N ; Wijeysundera, D ; Eskander, A ; Chadi, S ; MacKenzie, S ; Flexman, A ; Heredia, F ; Marta Modolo, M ; Villanueva, J ; Waissbluth, S ; Macchiavello, R ; Escudero, MI ; Fuentes, T ; Mimica, X ; Olivos, M ; Bolivar Saenz, D ; Caicedo, L ; Pablo Alzate, J ; Luna, J ; Pedraza Alonso, NF ; Ortiz Silva, C ; Rodriguez, J ; Silva-Igua, L ; Torres, ML ; Maria Trujillo, L ; Nieto Calvache, AJ ; Balanta-Melo, J ; Figueroa-Casanova, R ; Garcia-Montoya, O-J ; Marulanda Toro, CA ; Velez Botero, M ; Mendoza Arango, MC ; Diaz Martinez, E ; Gutierrez Perdomo, V ; Montenegro, E ; Mihanovic, J ; Aviles Jimenez, PM ; Gouvas, N ; Novysedlak, R ; Rodriguez-Abreu, J ; Mejia, D ; Lincango-Naranjo, E ; Abouelnagah, G ; Shehata, S ; Rida, AHEF ; Hassan, RA ; Saad, MM ; Loaloa, MR ; Mostafa, B ; Qassem, M ; Fahmy, M ; Abozied, H ; Azzam, AY ; Ghozy, S ; Sallam, A ; Shehta, A ; Emile, S ; Abdelkhalek, M ; Samaka, R ; Morsy, A ; Sherif, AE ; Negussie, A ; Fisseha, T ; Shumbash, K ; Abebe, M ; Hailu, S ; Yasin, SM ; Akililu, YB ; Megersa, A ; Tefera, T ; Assefa, M ; Atnafu, B ; Tsegaye, B ; Bezabih, YS ; Sisay, S ; Bekele, K ; Jira, M ; Mengesha, MG ; Derilo, H ; Degefa, E ; Tadesse, A ; Nidaw, M ; Sarjanoja, E ; Kauppila, JH ; Testelin, S ; Boucher, S ; Jouffret, L ; Lakkis, Z ; Le Bian, AZ ; Harper, L ; des Deserts, MD ; Andre, B ; Slim, K ; Verhaeghe, R ; Police, A ; Girard, E ; Chebaro, A ; Nkembi, AS ; Arnalsteen, L ; Ballouhey, Q ; Mege, D ; Jeandel, C ; Duchalais, E ; Bouche, P-A ; Manceau, G ; Cretolle, C ; Hervieux, E ; Girard, N ; Seguin-Givelet, A ; Gaujoux, S ; De Simone, B ; Boisson, M ; Bergeat, D ; Arnaud, AP ; Fredon, F ; Nappi, F ; Kassir, R ; Scalabre, A ; Migliorelli, F ; Verhaeghe, R ; Ezanno, A-C ; Seeliger, B ; Vaysse, C ; Charbonneau, H ; Misrai, V ; Abbo, O ; Angeles, MA ; Brunaud, L ; Demetrashvili, Z ; Modabber, A ; Wolf, S ; Kamphues, C ; Hoehn, P ; Glowka, TR ; Rokohl, AC ; Bork, U ; Fluegen, G ; Horch, RE ; Schmedding, A ; Schnitzbauer, A ; Eberbach, H ; Schlager, D ; Spelsberg, F ; Keppler, L ; Hecker, A ; Wolfer, S ; Ronellenfitsch, U ; Nitschke, C ; Peiper, C ; Hakami, I ; Welter, S ; Nikolaieva, K ; Roth, A ; Lindert, J ; Gousias, K ; Rissmann, A ; Linz, VC ; Rahbari, N ; Rassweiler-Seyfried, M-C ; Gut, AE ; Gempt, J ; Reim, D ; Wagner, A ; Albertsmeier, M ; Keppler, AM ; Stoleriu, MG ; Saier, T ; Stadler, J ; Kaiser, JC ; Brunner, SM ; Pfister, K ; Herzberg, J ; Nowak, K ; Reinhard, T ; Stavrou, GA ; Koenigsrainer, A ; Konrads, C ; Quante, M ; Laban, S ; von Pusch, S ; Hirschburger, M ; Doerner, J ; Wiegering, A ; Tampaki, EC ; Gutierrez Ruiz, A ; Rodas, A ; Lucia Portilla, A ; Recinos, G ; Aguilera-Arevalo, M-L ; Carrera, J ; Duarte, AB ; Lowey, M ; Barillas, S ; Suroy, A ; Vaishnav, D ; Chowdappa, RG ; Madabhavi, I ; Bhat, D ; Venkatappa, SK ; Thakar, S ; Jain, K ; Kumar, A ; Nagar, M ; Mishra, T ; Sekar, A ; Gupta, A ; Kaman, L ; Karthigeyan, M ; Tripathi, M ; Rammohan, A ; Vayoth, SO ; Rajanbabu, A ; Subbian, A ; Gupta, R ; Raut, M ; Evelyn R, N ; Kannaiyan, L ; Matai, A ; Misra, S ; Bhende, V ; Muthu, S ; Ghosh, I ; Sharma, A ; Bajaj, A ; Rajan, S ; Agarwal, G ; Pawar, P ; Alexander, P ; Vijayakumar, MV ; Hameed, BMZ ; Badareesh, L ; Chaudhry, NK ; Baliarsing, L ; Dharap, S ; Kulkarni, A ; Thyavihally, Y ; Sharma, RD ; Pramesh, CS ; Soni, R ; Dube, SK ; Sharma, S ; Singh, H ; Bains, L ; Ghodke, R ; Kumar, A ; Sodhai, V ; Maji, S ; Basu, S ; Mahakalkar, C ; Kannan, R ; Mehraj, A ; Ranganath, N ; Phadnis, A ; Yadev, I ; Kavalaka, A ; Mittal, R ; Vallam, KC ; Akhavizadegan, H ; Maleki, ER ; Kandevani, NY ; Ikele, H ; McNestry, C ; Fleming, C ; O'Brien, S ; Abd Elwahab, S ; Davis, N ; Javadpour, M ; McDonnell, B ; Connor, CO ; Bolger, J ; Clancy, C ; Croghan, SM ; Donlon, N ; Cullinane, C ; Creavin, B ; Muheilan, M ; Earley, H ; Kabir, SMU ; Fahadullah, M ; Ryan, E ; Connelly, T ; Zmora, O ; Hashimoto, D ; Alqudah, MA ; Alajalen, A ; Omari, RY ; Ayasra, F ; Qasem, A ; Alawneh, Y ; Ahmad, A ; Aladawi, O ; Alrayes, B ; Haidar, H ; Husain, S ; Qassem, F ; Sumadi, A ; Abu Salhiyeh, A ; Al-Manaseer, BM ; Alsunna, Z ; Ra'ed, H ; Hamad, FRB ; Abuleil, A ; Abou Chaar, MK ; Jimaale, EAM ; Abu-Mehsen, M ; Olaywah, N ; Wafi, O ; Ababneh, H ; Abu-Ismail, L ; Khamees, A ; Alkhatib, A ; Bolatbekova, R ; Kulimbet, M ; Nurgozhin, T ; Saliev, T ; Zhussupov, B ; Almabayev, Y ; Fakhradiyev, I ; Saliev, T ; Kaidarova, D ; Tamoos, K ; Aqeelah, A ; Mohammed, AAK ; Al Maadany, F ; Alkadeeki, G ; Gahwagi, M ; Aldressi, W ; Amnaina, M ; Alansari, AHA ; Alkaseek, A ; Yagoub, G ; Ben Amer, A ; Salem, M ; Almugaddami, A ; Burgan, D ; Abdelkabir, M ; Alshareef, K ; Ben Jouira, RAI ; Meelad, A ; Bouhuwaish, A ; Dwaga, SE ; Khalifa, H ; Almiqlash, B ; Suliaman, T ; Alawami, M ; Elhajdawe, F ; Aboazamazem, H ; Ellojli, I ; Msherghi, A ; Saleh, IA ; Alayan, M ; Roslani, AC ; Ndayishyigikiye, MD ; Munyika, A ; Plarre, P ; Borowski, DW ; Nashidengo, PR ; Noltes, M ; Steinkamp, P ; Wells, C ; Teague, R ; Elliott, B ; Kieser, D ; Mohyieldin, O ; Varghese, C ; McIntosh, N ; Haran, C ; Rennie, S ; King, J ; Ha, J ; McGuinness, MJ ; Adesanya, O ; Olaogun, J ; Akinmade, A ; Bwala, K ; Agbonrofo, P ; Afolabi, A ; Usang, U ; Ekenze, S ; Olori, S ; Lawal, TA ; Seyi-Olajide, J ; Okunlola, A ; Ekiti, I ; Williams, O ; Adisa, A ; Abdur-Rahman, L ; Kache, S ; Sale, D ; Anyanwu, L-J ; Okereke, C ; Tolani, MA ; Filipce, V ; Todorovic, L ; Pejkova, S ; Stavridis, S ; Massoud, JG ; Alsibai, S ; Sultan, R ; Altaf, HN ; Bhatti, ABH ; Waqar, SH ; Aziz, A ; Kerawala, AA ; Rai, L ; Anwer, M ; Tariq, A ; Ayub, B ; Niazi, SU ; Naseem, MY ; Sarwar, MZ ; Khokhar, MI ; Zahid, IA ; Majid, HJ ; Talat, N ; Asif, M ; Chaudhary, MH ; Farooq, U ; Ahmad, S ; Mabood, W ; Bukhari, SI ; Tariq, M ; Yaqoob, E ; Javed, S ; Malik, MU ; Yaqoob, HN ; Cukier, M ; Falcon Pacheco, GM ; Mas Melendez, R ; Paucar Urbina, ADP ; Rios Chiuyari, J ; Otiniano Alvarado, CE ; Rivera Lau, LF ; Borda-Luque, G ; Niquen-Jimenez, M ; Arias, C ; Zegarra, S ; Betalleluz Pallardel, J ; Ugarte Oscco, RA ; Mendiola, G ; Carpio Colmenares, YT ; Zapata, CS ; Rosa Ortiz, M ; Dione Sacdalan, M ; Major, P ; Borges, FC ; Viveiros, O ; Serralheiro, P ; Santos-Costa, P ; Mendes, F ; Melo, MR ; Cardoso, P ; Soares, A ; Azevedo, J ; Pereira, RG ; Silva, N ; Caiado, A ; Sacras, ML ; Azevedo, P ; Almeida-Reis, R ; Cunha, MF ; Oliveira, J ; Nogueiro, J ; Sampaio-Alves, M ; Costa, LC ; Baia, C ; Deus, AC ; Branquinho, R ; Marcal, A ; Tojal, A ; Zarour, A ; Makkai-Popa, ST ; Mironescu, A ; Grama, F ; Toma, EA ; Negoi, I ; Filipescu, D ; Bacalbasa, N ; Motas, N ; Ionescu, S ; Ginghina, O ; Costea, R ; Zarnescu, NO ; Drasovean, R ; Bonci, E-A ; Dimofte, M-G ; Porumb, V ; Kirov, M ; Molitvin, Y ; Litvin, A ; Pykhteev, V ; Raevskaya, M ; Efetov, S ; Butyrskii, A ; Alshahrani, M ; Althumairi, A ; Alzerwi, N ; Al Ameer, A ; Madkhali, T ; Almulhim, AS ; Ghazwani, S ; Ayoub, A ; Iskander, O ; Ghunaim, M ; Alharthi, M ; Alzaidi, TM ; Althumairi, A ; Alyami, M ; Al Amri, A ; Althumairi, A ; AlFakhri, A ; Alhefdhi, A ; Chowdhury, S ; Nouh, T ; Alshehri, A ; Alzahrani, A ; Alalawi, Y ; Awad, S ; Konate, I ; Ndong, A ; Tendeng, J ; Teo, NZ ; Koh, F ; Kosir, JA ; Bele, U ; Aqil, S ; Barrena Lopez, C ; Sanchez Mozo, A ; Rodriguez Infante, A ; Caja Vivancos, P ; Prieto, M ; Alberdi San Roman, I ; Gomez Fernandez, L ; Munoz Vives, JM ; Carreras-Castaner, A ; Diaz-Feijoo, B ; Sieira-Gil, R ; Turrado-Rodriguez, V ; Sanchez Lopez, A ; Sanchez-Cabus, S ; Jimenez Toscano, M ; Canals Sin, MP ; Garcia Laura, S ; Martin Sole, O ; Palazon Bellver, P ; Perez-Bertolez, S ; Prat-Ortells, J ; Riba Martinez, M ; Rubio-Palau, J ; Tarrado, X ; Nunez, J ; Alonso Mendoza, V ; Bescos, C ; Espin-Basany, E ; Espinosa-Bravo, M ; Gil-Sala, D ; Gonzalez-Suarez, S ; Montferrer Estruch, N ; Porteiro Marino, L ; Rodriguez-Tesouro, A ; Rojas Portilla, F ; Tormos Perez, MP ; Vives, I ; Garcia De Cortazar, U ; Tudela, K ; Landaluce-Olavarria, A ; Estaire Gomez, M ; Almoguera, J ; Ugarte-Sierra, B ; Jimenez, V ; Bertrand, M ; Cardenas Puiggros, L ; Delisau-Puig, O ; Garcia-Adamez, J ; Julia Bergkvist, D ; Maldonado-Marcos, E ; Diego Garcia, L ; Roldon Golet, M ; Soto-Darias, I ; Cristina Rahy-Martin, A ; Enjuto, D ; Ramos-Luengo, A ; Delgado Fernandez, J ; Lugo Duarte, C ; Ojeda Thies, C ; Marquez, L ; Crego Vita, D ; Dziakova, J ; Minaya Bravo, AM ; Canno Velasco, J ; Mateo-Sierra, O ; Quintana-Villamandos, B ; Rey Valcarcel, C ; Rio, J ; Roman Garcia de Leon, L ; Di Martino, M ; Prada, J ; Serrano Gonzalez, J ; Losada, M ; Castell Gomez, JT ; Corripio-Sanchez, R ; Forero-Torres, A ; Manuel Morales-Puebla, J ; Perez-Chrzanowska, H ; Valderrabano Gonzalez, S ; Yebes, A ; Zapardiel, I ; Diez Alonso, M ; Morales Palacios, N ; Cabanero Sanchez, A ; Sanchez Fernandez, F ; Abad Gurumeta, A ; Abad-Motos, A ; Corella, F ; Ripolles-Melchor, J ; Sanz-Gonzalez, R ; Alcaraz Fuentes, M ; Fernandez Martin, MT ; Calvo Espino, P ; Carrasco Prats, M ; Fernandez-Lopez, A-J ; Garcia Escudero, D ; Garcia Soria, V ; Martinez Alonso, JA ; Ruiz-Marin, M ; Gomez Perez, B ; Moya-Angeler, J ; Fernandez Martinez, D ; Llaquet Bayo, H ; Colas-Ruiz, E ; Bella Romera, S ; Gavalda Pellice, MT ; Jorda Sole, M ; Ruiz Velasquez, EJ ; Nunez, B ; Jimenez, R ; Zabaleta, J ; Jose Gonzalez-Gimeno, M ; Ortega Vazquez, I ; Perez Ferrer, A ; Martin-Laez, R ; Moreno Suarez, M ; Freiria Eiras, MA ; Ramallo-Solis, I ; Gomez-Rosado, J-C ; Oliver Guillen, JR ; Achalandabaso Boira, M ; Catala Bauset, JC ; Domenech, J ; Badenes, R ; Carlos Bernal-Sprekelsen, J ; Sancho-Muriel, J ; De Andres-Asenjo, B ; Tejero-Pintor, FJ ; Vallve-Bernal, M ; Vazquez Melero, A ; Das, A ; Ganapathy, T ; Gunarasa, Y ; Mariapan, K ; Muniandy, M ; Osman, MF ; Azmi, MAFM ; Soh, JY ; Zain, WZW ; Zakaria, AD ; Zakaria, Z ; Chan, KH ; Hayati, F ; Johan, S ; Mah, JJ ; Sriram, RK ; Subramaniam, S ; Shahimi, NSBM ; Hamdan, KH ; Ibrahim, MR ; Muthkumaran, G ; Tan, JA ; Thanapal, MR ; Aziz, DAA ; Bastion, M-L ; Harun, MHN ; Imran, F-H ; Din, NM ; Zain, AM ; Mustapha, M ; Nabil, S ; Naffi, AA ; Nazimi, AJ ; Ramli, R ; Soon, BH ; Bal, P ; Cheng, JQ ; Draman, MR ; Fadzli, AN ; Ghauth, S ; Hung, W ; Jamaris, S ; Koh, PS ; Krishnasamy, S ; Lee, YS ; Liew, YT ; Lim, JZ ; Lim, RCS ; Lim, HC ; Pauzi, SFM ; Nah, SA ; Nair, AK ; Ng, DSW ; Yong, YJNW ; Ramayah, K ; Roslani, AC ; Saaid, R ; Sanmugam, A ; See, MH ; Seevalingam, KK ; Sethi, N ; Singaravel, S ; Ganapathy, T ; Gunarasa, Y ; Mariapan, K ; Muniandy, M ; Osman, MF ; Azmi, MAFM ; Soh, JY ; Zain, WZW ; Zakaria, AD ; Zakaria, Z ; Chan, KH ; Hayati, F ; Johan, S ; Mah, JJ ; Sriram, RK ; Subramaniam, S ; Zaidi, SNSJH ; Tang, CY ; Teoh, LY ; Wong, KB ; Xavier, R ; Yahaya, AS (WILEY, 2021-11)
    We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05-1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4-7 days or ≥ 8 days of 1.25 (1.04-1.48), p = 0.015 and 1.31 (1.11-1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care.