Melbourne Dental School - Research Publications

Permanent URI for this collection

Search Results

Now showing 1 - 5 of 5
  • Item
    No Preview Available
    Other Mucosal Malignancies: Oral Melanoma, Oral Lymphomas, and Oral Kaposi Sarcoma
    Celentano, A ; Calabria, E ; Balasubramaniam, R ; Yeoh, S-C ; Yap, T ; Prabhu, R (Springer, 2023)
    Malignancies of the oral mucosa comprise a wide variety of neoplasms. Beside the most common oral squamous cell carcinoma and salivary gland malignancies, there are other malignancies affecting the oral cavity, which are worth of consideration due to their local and systemic severity. In this section, three malignancies will be discussed: oral melanoma, oral lymphomas, and oral Kaposi sarcoma.
  • Item
    No Preview Available
    Osteoporosis and Medication-Related Osteonecrosis of the Jaws
    Celentano, A ; Calabria, E ; Balasubramaniam, R ; Yeoh, S-C ; Yap, T ; Prabhu, R (Springer, 2023)
    Osteoporosis is a metabolic bone disease characterized by decreased bone strength and an increased susceptibility to fractures. Anti-resorptive therapies are extremely effective in preventing skeletal adverse events in osteoporotic patients. However, these drugs have been also recognized as a principal risk factor for the development of medication-related osteonecrosis of the jaws (MRONJ). MRONJ consists of non-healing and necrosis of the bone associated with symptoms and infection. Although MRONJ management continues to be challenging for clinicians, data suggests a high rate of success for surgical treatments.
  • Item
    Thumbnail Image
    Taxonomy of Oral Bacteria
    Byrne, SJ ; Butler, CA ; Reynolds, EC ; Dashper, SG ; Gurtler, V ; Trevors, JT (ELSEVIER ACADEMIC PRESS INC, 2018-01-01)
    The oral cavity is a collection of diverse microenvironments, each inhabited by a community of microorganisms, the majority of which are bacteria and their phages. Given the appropriate conditions, some of these bacteria can cause destruction of the teeth or their supporting hard and soft tissues. For over 300 years microbiologists have been characterising these microbial communities, in both oral health and disease. In this chapter, we take the reader on a journey through time as we discuss the various methods that have been utilised in the characterisation of the bacteria calling the oral cavity home, and how the use of these methods has informed our understanding of oral bacterial communities and the diversity of their members.
  • Item
    Thumbnail Image
    Molecular Interactions of Peptide Encapsulated Calcium Phosphate Delivery Vehicle at Enamel Surfaces
    Huq, NL ; Cross, KJ ; Myroforidis, H ; Stanton, DP ; Chen, YY ; Ward, BR ; Reynolds, EC ; Nagasawa, H ; Kogure, T ; Endo, K (Springer, 2018-12-31)
    Phosphorylated peptides derived from milk caseins, known as casein phosphopeptides (CPP) self-assemble and encapsulate the calcium and phosphate mineral in the form of amorphous calcium phosphate (ACP) thus forming CPP-ACP nanocomplexes that are non-toxic and bio-compatible. The biomedical application is the repair of tooth surfaces (enamel) at early stages of tooth decay. These nanocomplexes release calcium and phosphate ions to rebuild demineralised HA crystals in enamel subsurface lesions. The topical application of CPP-ACP at the tooth surface initiates a series of interactions at the enamel mineral hydroxyapatite surface, and at the enamel salivary pellicle that are not well understood. In this study, we have shown that the β-casein (1-25) peptide binds reversibly to Ca2+, Mg2+, Mn2+, La2+, Ni2+, and Cd2+ metal ions. In contrast, binding to Sn2+, Fe2+, and Fe3+ ions, resulted in ion-induced aggregation. The casein peptides as well as the mineral ions dissociate from the CPP-ACP complexes to adsorb to both the un-coated and saliva-coated mineral surface with the mineralisation increasing monotonically with increasing pH. Furthermore, SEM of the CPP-ACP revealed images of spherical particles surrounded by ACP mineral. In conclusion, the enamel remineralisation process involves an array of interactions between the peptide and mineral ions of the CPP-ACP delivery vehicle and the tooth enamel mineral with its salivary pellicle.
  • Item
    No Preview Available
    Teleconsultation and Telediagnosis for Oral Health Assessment: An Australian Perspective
    Marino, R ; Clarke, K ; Manton, DJ ; Stranieri, A ; Collmann, R ; Kellet, H ; Borda, A ; Kumar, S (SPRINGER, 2015)