Medicine (Austin & Northern Health) - Research Publications

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Start date: 1981 × End date: 1989 × Author: Morahan, Grant ×

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    Induction of delayed-type hypersensitivity to azobenzenearsonate by a monoclonal anti-idiotype antibody.
    Thomas, WR ; Morahan, G ; Walker, ID ; Miller, JF (Rockefeller University Press, 1981-03-01)
    Azobenzenearsonate (ABA)-specific sensitivity was induced in A/J mice by injecting a monoclonal anti-idiotype reagent, 14A, directed against a determinant present on a minor subpopulation of immunoglobulin molecules within the anti-ABA antibodies of A/J mice. Sensitivity was transferrable by purified T cells and this was abrogated by treating the cells with 14A, rabbit anti-mouse immunoglobulin and complement, not by treatment with only the last two reagents. The transfer was restricted by the K-end of the major histocompatibility complex.