Medicine (Austin & Northern Health) - Research Publications

Permanent URI for this collection

http://hdl.handle.net/11343/211

Filters

2007 - 2009 2 2010 - 2017 1
3
Reset filters

Settings
Statistics
Citations
Start date: 2000 × Author: Johnson, Paul × Author: Hughes, Andrew ×

Search Results

Now showing 1 - 3 of 3
  • Item
    No Preview Available
    Risk Factors forMycobacterium ulceransInfection, Southeastern Australia
    Quek, TYJ ; Athan, E ; Henry, MJ ; Pasco, JA ; Redden-Hoare, J ; Hughes, A ; Johnson, PDR (Centers for Disease Control and Prevention (CDC), 2007-11)
  • Item
    Thumbnail Image
    Successful treatment of Mycobacterium ulcerans osteomyelitis with minor surgical debridement and prolonged rifampicin and ciprofloxacin therapy: a case report.
    O'Brien, DP ; Athan, E ; Hughes, A ; Johnson, PD (Springer Science and Business Media LLC, 2008-04-27)
    INTRODUCTION: Treatment for osteomyelitis-complicating Mycobacterium ulcerans infection typically requires extensive surgery and even amputation, with no reported benefit from adjunctive antibiotics. CASE PRESENTATION: We report a case of an 87-year-old woman with M. ulcerans osteomyelitis that resolved following limited surgical debridement and 6 months of therapy with rifampicin and ciprofloxacin. CONCLUSION: M. ulcerans osteomyelitis can be successfully treated with limited surgical debridement and adjunctive oral antibiotics.
  • Item
    Thumbnail Image
    The location of Australian Buruli ulcer lesions-Implications for unravelling disease transmission
    Yerramilli, A ; Tay, EL ; Stewardson, AJ ; Kelley, PG ; Bishop, E ; Jenkin, GA ; Starr, M ; Trevillyan, J ; Hughes, A ; Friedman, ND ; O'Brien, DP ; Johnson, PDR ; Pluschke, G (PUBLIC LIBRARY SCIENCE, 2017-08)
    BACKGROUND: Buruli ulcer (BU), caused by Mycobacterium ulcerans, is increasing in incidence in Victoria, Australia. To improve understanding of disease transmission, we aimed to map the location of BU lesions on the human body. METHODS: Using notification data and clinical records review, we conducted a retrospective observational study of patients diagnosed with BU in Victoria from 1998-2015. We created electronic density maps of lesion locations using spatial analysis software and compared lesion distribution by age, gender, presence of multiple lesions and month of infection. FINDINGS: We examined 579 patients with 649 lesions; 32 (5.5%) patients had multiple lesions. Lesions were predominantly located on lower (70.0%) and upper (27.1%) limbs, and showed a non-random distribution with strong predilection for the ankles, elbows and calves. When stratified by gender, upper limb lesions were more common (OR 1·97, 95% CI 1·38-2·82, p<0·001) while lower limb lesions were less common in men than in women (OR 0·48, 95% CI 0·34-0·68, p<0·001). Patients aged ≥ 65 years (OR 3·13, 95% CI 1·52-6·43, p = 0·001) and those with a lesion on the ankle (OR 2·49, 95% CI 1·14-5·43, p = 0·02) were more likely to have multiple lesions. Most infections (71.3%) were likely acquired in the warmer 6 months of the year. INTERPRETATION: Comparison with published work in Cameroon, Africa, showed similar lesion distribution and suggests the mode of M. ulcerans transmission may be the same across the globe. Our findings also aid clinical diagnosis and provide quantitative background information for further research investigating disease transmission.