Computing and Information Systems - Research Publications

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Author: Sinnott, Richard × Type: Journal Article × Subject: clinical trials ×

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    Development of grid frameworks for clinical trials and epidemiological studies
    SINNOTT, RICHARD ; STELL, ANTHONY ; Ajayi, Oluwafemi (IOS Press, 2006)
    E-Health initiatives such as electronic clinical trials and epidemiological studies require access to and usage of a range of both clinical and other data sets. Such data sets are typically only available over many heterogeneous domains where a plethora of often legacy based or in-house/bespoke IT solutions exist. Considerable efforts and investments are being made across the UK to upgrade the IT infrastructures across the National Health Service (NHS) such as the National Program for IT in the NHS (NPFIT) [1]. However, it is the case that currently independent and largely non-interoperable IT solutions exist across hospitals, trusts, disease registries and GP practices – this includes security as well as more general compute and data infrastructures. Grid technology allows issues of distribution and heterogeneity to be overcome, however the clinical trials domain places special demands on security and data which hitherto the Grid community have not satisfactorily addressed. These challenges are often common across many studies and trials hence the development of a re-usable framework for creation and subsequent management of such infrastructures is highly desirable. In this paper we present the challenges in developing such a framework and outline initial scenarios and prototypes developed within the MRC funded Virtual Organisations for Trials and Epidemiological Studies (VOTES) project [2].
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    User-oriented security supporting inter-disciplinary life science research across the grid
    Sinnott, R ; Ajayi, O ; Jiang, J ; Stell, A ; Watt, J (SPRINGER, 2007)
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    Supporting grid-based clinical trials in Scotland
    Sinnott, R. O. ; Stell, A. J. ; Ajayi, O. (Sage, 2008)
    A computational infrastructure to underpin complex clinical trials and medical population studies is highly desirable. This should allow access to a range of distributed clinical data sets; support the effi cient processing and analysis of the data obtained; have security at its heart; and ensure that authorized individuals are able to see privileged data and no more. Each clinical trial has its own requirements on data sets and how they are used; hence a reusable and fl exible framework offers many advantages. The MRC funded Virtual Organisations for Trials and Epidemiological Studies (VOTES) is a collaborative project involving several UK universities specifi cally to explore this space. This article presents the experiences of developing the Scottish component of this nationwide infrastructure, by the National e-Science Centre (NeSC) based at the University of Glasgow, and the issues inherent in accessing and using the clinical data sets in a fl exible, dynamic and secure manner.