Medicine (Austin & Northern Health) - Theses

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Start date: 1986 × End date: 1989 ×

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    A study to identify risk factors in the aetiology and cause of traumatic spinal cord paralysis
    Toscano, Giuseppe ( 1986)
    This thesis is primarily concerned with determining: I. Primary and Secondary risk factors in traumatic spinal cord paralysis. (a) PRIMARY RISK FACTORS are those factors which predispose an individual to develop traumatic spinal cord paralysis. (b) SECONDARY RISK FACTORS are those factors which determine prognosis from time of injury to the time the patient is admitted to the emergency room of the Spinal Injuries Unit. II. Developing a preventive programme based on the elucidated Primary and Secondary risk factors. All patients who sustained significant spinal cord injuries in Victoria or within 25 kilometres of the Victorian border who were admitted to the Victorian Spinal Injuries Unit, Austin Hospital during the study period (1st March 1983 to 28th December 1984) were included in the study.
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    The pharmacokinetics and pharmacodynamics of calcium antagonists
    Razak, Tariq Bin Abdul ( 1988)
    This thesis describes the development of a specific, sensitive and reliable method for the simultaneous measurement of the parent drug and one of its metabolites at nanogram/ml levels for the dihydropyridines - nicardipine and. PY-108-068 in plasma. It demonstrates the application of pharmacokinetic principles and their relationship to the pharmacodynamic properties of these compounds. Increased systemic bioavailability of nicardipine with a corresponding increase in pharmacodynamic effect is shown in patients with liver disease, demonstrating the importance of the hepatic first-pass metabolism for this compound. Saturation kinetics are demonstrated for the PY-108-068 within the single dose range of 50-200mg orally. Age and concominant food ingestion does not significantly affect the elimination half-lives of PY- 108-068. This study demonstrates that PY-108-068 is more effective in lowering the blood pressure of patients in the old age-group, as compared to that in the young age-group, and that inhibition of reflex tachycardia occurs at higher blood levels than those producing a vasdilator effect. There is good correlations between plasma levels and blood pressure response for both nicardipine and PY-108-068.