Paediatrics (RCH) - Research Publications

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Author: Bines, Julie × End date: 2009 × Type: Journal Article ×

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    The burden of hospitalised rotavirus infections in Fiji
    Jenney, A ; Tikoduadua, L ; Buadromo, E ; Barnes, G ; Kirkwood, CD ; Boniface, K ; Bines, J ; Mulholland, K ; Russell, F (ELSEVIER SCI LTD, 2009-11-20)
    Rotavirus is the most common cause of acute severe dehydrating diarrhoea in young children worldwide. We describe the burden of rotavirus disease and the rotavirus types causing it in the largest city in Fiji. During 2006 and 2007, 592 children under 5 years of age were admitted to hospital in Suva, Fiji with acute diarrhoea. Of the 454 children for whom a stool specimen was tested, 39% were positive for rotavirus and the predominant strain found was the serotype G3[P8]. There is a significant burden of disease due to rotavirus in Fiji and the introduction of rotavirus vaccines into the national immunization schedule may drastically reduce inpatient diarrhoeal disease.
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    Validation of clinical case definition of acute intussusception in infants in Viet Nam and Australia
    BINES, JULIE ; Liem, Nguyen Thanh ; Justice, Frances ; Son, Tran Ngoc ; CARLIN, JOHN ; DE CAMPO, MARGARET ; JAMSEN, KRIS ; Mulholland, Edward ; BARNETT, PETER ; BARNES, GRAEME ( 2006)
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    Risk factors for intussception in infants in Vietnam and Australia: Adenovirus implicated, but not rotavirus
    BINES, JULIE ; Liem, Nguyen Thanh ; Justice, Frances ; Son, Tran Ngoc ; KIRKWOOD, CARL ; DE CAMPO, MARGARET ; BARNETT, PETER ; BISHOP, RUTH ; ROBINS-BROWNE, ROY ; CARLIN, JOHN ( 2006)
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    Molecular epidemiology of adenovirus isolates from patients diagnosed with intussusception in Melbourne, Australia
    Selvaraj, G ; Kirkwood, C ; Bines, J ; Buttery, J (AMER SOC MICROBIOLOGY, 2006-09)
    Twenty-one intussusception (IS)-associated and 59 temporally linked adenoviral isolates from clinical infections were compared. Species C (15/21 IS- and 32/59 non-IS-associated isolates) dominated. Of these, serotype 2 (AdV-2) (7/15 IS-associated isolates) and serotype 1 (AdV-1) (16/32 non-IS-associated isolates) were the most commonly identified serotypes. DNA restriction analysis of AdV-2 isolates identified six genomic types; of these, type D2 (3/7 IS- and 8/11 non-IS-associated isolates) was the dominant type after BamHI and SmaI digestion. IS-associated isolates are similar to circulating non-IS-associated strains.
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    Energy metabolism in infants with cystic fibrosis
    Bines, JE ; Truby, HD ; Armstrong, DS ; Phelan, PD ; Grimwood, K (MOSBY-ELSEVIER, 2002-05)
    OBJECTIVE: To determine whether a defect in energy metabolism exists in infants with cystic fibrosis (CF). DESIGN: Unselected, newly-diagnosed subjects with CF (n = 46) and 24 healthy infants aged <20 weeks had measurements of resting energy expenditure (REE), total energy expenditure (TEE) (n = 25), and body composition. Metabolizable energy intake (MEI) was calculated. Genotype, energy intake, and pancreatic status was determined in all subjects with CF, and 24 underwent bronchial lavage. RESULTS: At diagnosis, infants with CF detected by newborn screening had significant anthropometric deficits (mean [SD] z-weight = 0.5 [1.0], z-length = 0.7 [1.3]) associated with pancreatic insufficiency. Their REE, TEE, or MEI (absolute measurements, per unit body weight or fat-free mass) were not increased. No relationship between REE, TEE, or MEI and Delta F(508) genotype, and no proportional differences in individual components of MEI between subjects with CF and controls, or between subjects with CF who were homozygotes or compound heterozygotes for Delta F(508) were observed. REE and TEE were not correlated with bronchial infection or inflammation. CONCLUSION: Growth impairment during the first weeks of life in infants with CF is associated with pancreatic insufficiency. However, there is no evidence for a defect of energy metabolism related to Delta F(508), and in infants with CF, minimal lung disease is unaccompanied by increased energy expenditure.