Paediatrics (RCH) - Research Publications

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Author: Craig, Jeffrey × Author: Cutler, Tessa × Author: He, Mingguang × Author: Saffery, Richard × End date: 2019 ×

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    The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins
    Silventoinen, K ; Jelenkovic, A ; Yokoyama, Y ; Sund, R ; Sugawara, M ; Tanaka, M ; Matsumoto, S ; Bogl, LH ; Freitas, DL ; Maia, JA ; Hjelmborg, JVB ; Aaltonen, S ; Piirtola, M ; Latvala, A ; Calais-Ferreira, L ; Oliveira, VC ; Ferreira, PH ; Ji, F ; Ning, F ; Pang, Z ; Ordonana, JR ; Sanchez-Romera, JF ; Colodro-Conde, L ; Burt, SA ; Klump, KL ; Martin, NG ; Medland, SE ; Montgomery, GW ; Kandler, C ; McAdams, TA ; Eley, TC ; Gregory, AM ; Saudino, KJ ; Dubois, L ; Boivin, M ; Brendgen, M ; Dionne, G ; Vitaro, F ; Tarnoki, AD ; Tarnoki, DL ; Haworth, CMA ; Plomin, R ; Oncel, SY ; Aliev, F ; Medda, E ; Nistico, L ; Toccaceli, V ; Craig, JM ; Saffery, R ; Siribaddana, SH ; Hotopf, M ; Sumathipala, A ; Rijsdijk, F ; Jeong, H-U ; Spector, T ; Mangino, M ; Lachance, G ; Gatz, M ; Butler, DA ; Gao, W ; Yu, C ; Li, L ; Bayasgalan, G ; Narandalai, D ; Harden, KP ; Tucker-Drob, EM ; Christensen, K ; Skytthe, A ; Kyvik, KO ; Derom, CA ; Vlietinck, RF ; Loos, RJF ; Cozen, W ; Hwang, AE ; Mack, TM ; He, M ; Ding, X ; Silberg, JL ; Maes, HH ; Cutler, TL ; Hopper, JL ; Magnusson, PKE ; Pedersen, NL ; Dahl Aslan, AK ; Baker, LA ; Tuvblad, C ; Bjerregaard-Andersen, M ; Beck-Nielsen, H ; Sodemann, M ; Ullemar, V ; Almqvist, C ; Tan, Q ; Zhang, D ; Swan, GE ; Krasnow, R ; Jang, KL ; Knafo-Noam, A ; Mankuta, D ; Abramson, L ; Lichtenstein, P ; Krueger, RF ; McGue, M ; Pahlen, S ; Tynelius, P ; Rasmussen, F ; Duncan, GE ; Buchwald, D ; Corley, RP ; Huibregtse, BM ; Nelson, TL ; Whitfield, KE ; Franz, CE ; Kremen, WS ; Lyons, MJ ; Ooki, S ; Brandt, I ; Nilsen, TS ; Harris, JR ; Sung, J ; Park, HA ; Lee, J ; Lee, SJ ; Willemsen, G ; Bartels, M ; Van Beijsterveldt, CEM ; Llewellyn, CH ; Fisher, A ; Rebato, E ; Busjahn, A ; Tomizawa, R ; Inui, F ; Watanabe, M ; Honda, C ; Sakai, N ; Hur, Y-M ; Sorensen, TIA ; Boomsma, DI ; Kaprio, J (CAMBRIDGE UNIV PRESS, 2019-12)
    The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural-geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.
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    Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age: A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project
    Yokoyama, Y ; Jelenkovic, A ; Sund, R ; Sung, J ; Hopper, JL ; Ooki, S ; Heikkila, K ; Aaltonen, S ; Tarnoki, AD ; Tarnoki, DL ; Willemsen, G ; Bartels, M ; van Beijsterveldt, TCEM ; Saudino, KJ ; Cutler, TL ; Nelson, TL ; Whitfield, KE ; Wardle, J ; Llewellyn, CH ; Fisher, A ; He, M ; Ding, X ; Bjerregaard-Andersen, M ; Beck-Nielsen, H ; Sodemann, M ; Song, Y-M ; Yang, S ; Lee, K ; Jeong, H-U ; Knafo-Noam, A ; Mankuta, D ; Abramson, L ; Burt, SA ; Klump, KL ; Ordonana, JR ; Sanhez-Romera, JF ; Colodro-Conde, L ; Harris, JR ; Brandt, I ; Nilsen, TS ; Craig, JM ; Saffery, R ; Ji, F ; Ning, F ; Pang, Z ; Dubois, L ; Boivin, M ; Brendgen, M ; Dionne, G ; Vitaro, F ; Martin, NG ; Medland, SE ; Montgomery, GW ; Magnusson, PKE ; Pedersen, NL ; Aslan, AKD ; Tynelius, P ; Haworth, CMA ; Plomin, R ; Rebato, E ; Rose, RJ ; Goldberg, JH ; Rasmussen, F ; Hur, Y-M ; Sorensen, TIA ; Boomsma, DI ; Kaprio, J ; Silventoinen, K (CAMBRIDGE UNIV PRESS, 2016-04)
    We analyzed birth order differences in means and variances of height and body mass index (BMI) in monozygotic (MZ) and dizygotic (DZ) twins from infancy to old age. The data were derived from the international CODATwins database. The total number of height and BMI measures from 0.5 to 79.5 years of age was 397,466. As expected, first-born twins had greater birth weight than second-born twins. With respect to height, first-born twins were slightly taller than second-born twins in childhood. After adjusting the results for birth weight, the birth order differences decreased and were no longer statistically significant. First-born twins had greater BMI than the second-born twins over childhood and adolescence. After adjusting the results for birth weight, birth order was still associated with BMI until 12 years of age. No interaction effect between birth order and zygosity was found. Only limited evidence was found that birth order influenced variances of height or BMI. The results were similar among boys and girls and also in MZ and DZ twins. Overall, the differences in height and BMI between first- and second-born twins were modest even in early childhood, while adjustment for birth weight reduced the birth order differences but did not remove them for BMI.