Paediatrics (RCH) - Research Publications

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Author: Harrison, Joanne × Author: Ranganathan, Sarath × Author: Shanthikumar, Shivanthan × End date: 2023 × Start date: 2020 × Type: Journal Article ×

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    Patient and family perspectives regarding the use of telehealth for cystic fibrosis care
    Shanthikumar, S ; Moore, E ; Corda, J ; Reardon, N ; Louey, S ; Frayman, K ; Harrison, J ; Ranganathan, S (WILEY, 2021-05)
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    Optimism with Caution: Elexacaftor-Tezacaftor-Ivacaftor in Patients with Advanced Pulmonary Disease
    Kuek, SL ; Ranganathan, SC ; Harrison, J ; Robinson, PJ ; Shanthikumar, S (AMER THORACIC SOC, 2021-08-01)
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    Is cardiorespiratory disease associated with increased susceptibility of SARS-CoV-2 in children?
    Du Berry, C ; Saunders, T ; McMinn, A ; Tosif, S ; Shanthikumar, S ; Vandeleur, M ; Harrison, J ; Burgner, D ; Ranganathan, S ; Crawford, N ; Wurzel, D (WILEY, 2021-12)
    BACKGROUND: There are limited data in pediatric populations evaluating whether chronic cardiorespiratory conditions are associated with increased risk of coronavirus disease 2019 (COVID-19). We aimed to compare the rates of chronic cardiac and respiratory disease in children testing positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2[+]) compared with those testing negative (SARS-CoV-2[-]) at our institution. METHOD: Prospective cohort with nested case-control study of all children tested by polymerase chain reaction (PCR) for SARS-CoV-2 by nasopharyngeal/oropharyngeal sampling between March and October 2020. Children were identified prospectively via laboratory notification with age and sex-matching of SARS-CoV-2[+] to SARS-CoV-2[-] (1:2). Clinical data were extracted from the electronic medical record. RESULTS: In total, 179 SARS-CoV-2[+] children (44% females, median age 3.5 years, range: 0.1-19.0 years) were matched to 391 SARS-CoV-2[-] children (42% female, median age 3.7 years, range: 0.1-18.3 years). The commonest comorbidities showed similar frequencies in the SARS-CoV-2[+] and [-] groups: asthma (n = 9, 5% vs. n = 17, 4.4%, p = 0.71), congenital heart disease (n = 6, 3.4% vs. n = 7, 1.8%, p = 0.25) and obstructive sleep apnoea (n = 4, 2.2% vs. n = 10, 2.3%, p = 0.82). In the SARS-CoV-2[+] group, the prevalence of symptomatic disease was similar among children with and without cardiorespiratory comorbidities (n = 12, 75% vs. n = 103, 57%, p = 0.35). A high proportion of children hospitalized with SARS-CoV-2 infection had cardiac comorbidities (23.8%). CONCLUSIONS: In this single site data set, rates of pre-existing cardiorespiratory disease were similar in SARS-CoV-2[+] and SARS-CoV-2[-] children. Rates of symptomatic infection were similar between children with and without cardiorespiratory comorbidity. High rates of comorbid cardiac disease were observed among hospitalized children with COVID-19 warranting further research to inform vaccine prioritization.