Paediatrics (RCH) - Research Publications

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    Injury
    Greenham, M ; Ryan, N ; Anderson, V ; Gibb, R ; Kolb, B (Elsevier, 2017-11-02)
    Exploration of the consequences of brain insult sustained early in life has a long history, dating back to the 1920s and the seminal works of Lashley (1929), Kennard (1938, 1942), and Hebb (1949), and later comprehensive reviews (e.g., Finger & Stein, 1982; Isaacson, 1975; St James-Roberts, 1975). In this literature, while insults in infancy and early childhood were regarded as qualitatively and quantitatively distinct from those occurring in adulthood, there was little agreement regarding the potential benefits and vulnerabilities of early brain insult.
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    What the paediatrician needs to know when pandemic influenza arrives in clinical practice
    Ritz, N ; Curtis, N ; Finn, A ; Pollard, AJ (SPRINGER-VERLAG BERLIN, 2008)
    Avian (H5N1) influenza or “bird ‘flu” has received considerable attention in both the medical literature and the mass media in the last few years. Despite the tabloids’ portrayal of an imminent threat, to date there have been relatively few cases in humans in spite of large numbers of infected poultry (Hien et al. 2004). However, this may be falsely reassuring. Most indications suggest that it is just a matter of time until the next influenza pandemic occurs (Osterholm 2005). In the words of the UK Chief Medical Officer: “most experts believe that it is not a question of whether there will be another severe influenza pandemic but when” (Department of Health 2005). Although experts are agreed that a future influenza pandemic is almost inevitable, its timing is unpredictable and it is uncertain whether the virus responsible will be H5N1 or another, novel, influenza strain (Osterholm 2005). A recent editorial described avian influenza as a “predicament of extraordinary proportions” (Anonymous 2006). The next influenza pandemic will have a dramatic impact on all levels of health care including the everyday work of doctors. This chapter focuses on the clinical aspects of pandemic influenza about which paediatricians need to be familiar.
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    Pneumonia
    Howie, SRC ; Hamer, DH ; GRAHAM, S ; Quah, SR (Elsevier, 2017)
    Pneumonia is an important cause of morbidity and mortality globally. It is the leading cause of death in infants and young children with the majority of these deaths occurring in low income countries. Risk factors affecting incidence and outcome include extremes of age, poor nutrition, immunosuppression, environmental exposures and socioeconomic determinants. Pneumonia can be caused by a wide range of pathogens including bacteria, viruses and fungi, and the etiology varies by epidemiological setting, comorbidities and whether the pneumonia is community-acquired or hospital-acquired. Streptococcus pneumoniae is the major cause of community-acquired bacterial pneumonia while Gram negative bacteria, often resistant to multiple antibiotics, are common causes of hospital-acquired pneumonia and pneumonia in immunosuppressed individuals. Diagnosis is generally clinical and management is based mainly on knowledge of likely causative pathogens as well as clinical severity and presence of known risk factors. Timely and effective antibiotic treatment and oxygen therapy if hypoxemic are critical to patient outcomes. Preventive measures range from improved nutrition and hygiene to specific vaccines that target common causes in children and adults such as the pneumococcal or influenza vaccines.
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    Cholera
    GRAHAM, S ; McIntosh, N ; Helms, P ; Smyth, R (Churchill Livingstone, 2003)
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    The Roadmap for Childhood Tuberculosis.
    GRAHAM, S ; Detjen, AK ; Starke, JR ; Donald, PR (Oxford University Press, 2016-02-11)
    The Handbook of Child and Adolescent Tuberculosis is a state of the art clinical reference written and edited by the world's leading experts in childhood tuberculosis.
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    Pneumonia in HIV-infected children.
    GRAHAM, S ; Mulholland, K ; Weber, MW (Pinter & Martin Ltd, 2016-02-29)
    A key text about the global health issue of pneumonia, written by experts in the field.
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    Prevention and Mental Health Promotion in Adolescents: the evidence
    PATTON, GC ; OLSSON, CA ; TOUMBOUROU, JW ; ROWLING, L ; MARTIN, G ; WALKER, L (McGraw Hill Australia, 2002)
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    Child Development and Disability
    Efron, D ; Marraffa, C ; Reilly, S ; REDDIHOUGH, D (Wiley Blackwell, 2015)
    Resident Medical Officers' Handbook, Lawson JS, ed. (Foreword: Sloan LEG). 100 p. Snap-lock ring binder. 2nd edition (1975–1976).Residents Handbook, Roy N, Vance J, eds. (Foreword: Sloan LEG). 203 p. Snap-lock ring binder.
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    Antiallergic Strategies: Induction of Tolerance to Food
    Lack, G ; Santos, A ; Penagos, M ; Allen, K ; Wahn, ; Sampson, (Academic Press, 2015-01-01)
    In addition, the book unites key, global experts in the field who summarize their collective, and current, knowledge of the early stage of the "Atopic March", along with novel ideas for potential options of prevention.
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    Prevention and Natural History of Food Allergy
    Prescott, S ; ALLEN, K ; Leung, DYM ; Szefler, SJ ; Bonilla, FA ; Akdis, CA ; Sampson, H (Elsevier Health Sciences, 2016)
    The third edition of Pediatric Allergy continues this title's steadfast tradition of providing comprehensive, authoritative guidance on the day-to-day diagnosis and management of pediatric allergic and immunologic diseases.