Paediatrics (RCH) - Research Publications

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Now showing 1 - 9 of 9
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    French Intensive Care Society, International congress - Réanimation 2016.
    (Springer Science and Business Media LLC, 2016-06)
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    Disease Spectrum and Management of Children Admitted with Acute Respiratory Infection in Viet Nam
    Phuong, N ; Huyen, T ; Vinh, N ; Dien, T ; Graham, S ; Marais, B (Wiley, 2017-11-23)
    Background: Acute respiratory infection (ARI) is the most common reason for admission to paediatric wards in Viet Nam, being responsible for 39.9% of hospital admissions and 7.9% of hospital deaths in southern Viet Nam. However, few studies have explored the ARI disease spectrum observed in central Viet Nam or differences between primary (district), secondary (provincial) and tertiary (national) level hospitals. Aims: To assess the acute respiratory infection (ARI) disease spectrum, duration of hospitalisation and outcome in children hospitalised with an ARI in Viet Nam. Methods: We conducted a retrospective descriptive study of ARI admissions to primary (Hoa Vang District Hospital), secondary (Da Nang Hospital for Women and Children) and tertiary (National Hospital of Paediatrics in Ha Noi) level hospitals in Viet Nam over a 12-month period(01/09/2015 to 31/08/2016). Results: ARIs accounted for 27.9% (37,436 / 134,061) of all paediatric admissions; nearly half (47.6%) of all children admitted to Hoa Vang District Hospital. Most (64.6%) children hospitalised with an ARI were<2 years of age. Influenza/pneumonia accounted for 69.4% of admissions; tuberculosis for only 0.3%. Overall 284 (0.8%) children died; most deaths (269/284; 94.7%) occurred at the tertiary referral hospital. The average duration of hospitalization was 7.6 days (median 7 days). The average direct hospitalization cost per ARI admission was 157.5 USD in Da Nang Provincial Hospital. In total, 62.6% of admissions were covered by health insurance. Conclusions: ARI is a major cause of paediatric hospitalization in Viet Nam, characterized by prolonged hospitalization for relatively mild disease. There is huge potential to reduce unnecessary hospital admission and cost.
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    Tobacco product use and smoking frequency among US adults with intellectual and developmental disabilities
    Eisenbaum, E (WILEY, 2018-08)
    BACKGROUND: People with intellectual and developmental disabilities (IDD) have been overlooked in tobacco use research although they are likely to experience tobacco-related health disparities. This study examined tobacco product use and smoking frequency and amount among a sample of US Special Olympics athletes with IDD. METHODS: Multiple regression analysis was used to test whether age, gender, body mass index, blood pressure, bone density, eating fruits and vegetables and family member tobacco use were correlated with the number of cigarettes smoked per day. RESULTS: The sample of people with IDD who used tobacco (n = 501) were aged 18-75 (M = 33.37) and 76.4% were male. About 73.6% reported cigarette use only, 10.6% reported dual or poly use of cigarettes and other tobacco products (cigars, pipe, and chewing tobacco) and 15.8% reported using only tobacco products other than cigarettes. Men were more likely than women to use tobacco products other than cigarettes. Of the cigarette smokers, 79.6% were daily smokers, and their mean cigarettes per day was 10.08 (SD = 9.50). Special Olympics athletes who did not have low bone density and those who consumed fruits and vegetables less than daily reported higher numbers of cigarettes per day. CONCLUSIONS: Although people with IDD are less likely to use tobacco than the general population, study results suggest that people with IDD who smoke cigarettes are just as likely as smokers in the general US population to smoke daily. Improving overall health behaviours may be important in helping smokers with IDD to reduce their tobacco use. Research is needed to understand longitudinal patterns of tobacco use and how to prevent tobacco use among people with IDD.
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    Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination
    Ramanathan, S ; Mohammad, S ; Tantsis, E ; Nguyen, TK ; Merheb, V ; Fung, VSC ; White, OB ; Broadley, S ; Lechner-Scott, J ; Vucic, S ; Henderson, APD ; Barnett, MH ; Reddel, SW ; Brilot, F ; Dale, RC (BMJ PUBLISHING GROUP, 2018-02)
    OBJECTIVE: We characterised the clinical course, treatment and outcomes in 59 patients with relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination. METHODS: We evaluated clinical phenotypes, annualised relapse rates (ARR) prior and on immunotherapy and Expanded Disability Status Scale (EDSS), in 218 demyelinating episodes from 33 paediatric and 26 adult patients. RESULTS: The most common initial presentation in the cohort was optic neuritis (ON) in 54% (bilateral (BON) 32%, unilateral (UON) 22%), followed by acute disseminated encephalomyelitis (ADEM) (20%), which occurred exclusively in children. ON was the dominant phenotype (UON 35%, BON 19%) of all clinical episodes. 109/226 (48%) MRIs had no brain lesions. Patients were steroid responsive, but 70% of episodes treated with oral prednisone relapsed, particularly at doses <10 mg daily or within 2 months of cessation. Immunotherapy, including maintenance prednisone (P=0.0004), intravenous immunoglobulin, rituximab and mycophenolate, all reduced median ARRs on-treatment. Treatment failure rates were lower in patients on maintenance steroids (5%) compared with non-steroidal maintenance immunotherapy (38%) (P=0.016). 58% of patients experienced residual disability (average follow-up 61 months, visual loss in 24%). Patients with ON were less likely to have sustained disability defined by a final EDSS of ≥2 (OR 0.15, P=0.032), while those who had any myelitis were more likely to have sustained residual deficits (OR 3.56, P=0.077). CONCLUSION: Relapsing MOG antibody-associated demyelination is strongly associated with ON across all age groups and ADEM in children. Patients are highly responsive to steroids, but vulnerable to relapse on steroid reduction and cessation.
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    BIOACTIVITY IN AN AGGRECAN 32MER FRAGMENT IS MEDIATED VIA TOLL-LIKE RECEPTORS
    Fosang, AJ ; Golub, SB ; Last, K ; Lees, S ; Wilson, R ; Aspberg, A ; Little, CB ; Sutton, P (ELSEVIER SCI LTD, 2014-04)
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    AN OPEN LABEL CLINICAL PILOT STUDY OF RESVERATROL AS A TREATMENT FOR FRIEDREICH ATAXIA
    Yiu, EM ; Tai, G ; Peverill, R ; Lee, K ; Croft, K ; Mori, T ; Scheiber-Mojdehkar, B ; Sturm, B ; Praschberger, M ; Vogel, A ; Rance, G ; Stephenson, S ; Lockhart, P ; Sarsero, J ; Stockley, C ; Churchyard, A ; Evans-Galea, M ; Ryan, MM ; Corben, L ; Delatycki, M (WILEY-BLACKWELL, 2013-06)
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    Population Response To Change In Infant Feeding Guidelines For Allergy Prevention
    Tey, D ; Allen, KJ ; Peters, R ; Koplin, J ; Tang, MLK ; Gurrin, L ; Ponsonby, A-L ; Lowe, A ; Wake, M ; Dharmage, S (MOSBY-ELSEVIER, 2014-02)
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    Meningitis in children in Fiji: etiology, epidemiology and neurological sequeale
    Biaukula, V ; Mulholland, EK ; Tikoduadua, L ; Azzopardi, K ; Seduadua, A ; Temple, B ; Richmond, P ; Robbins-Browne, R ; Russell, F (ELSEVIER SCI LTD, 2012-06)