http://hdl.handle.net/11343/159 2021-02-24T14:36:54Z http://hdl.handle.net/11343/265776 Tan, YT; McPherson, G; Wilson, SJ 2018 The molecular basis of music ability and music-related phenotypes Chapter 2018-01-01T00:00:00Z http://hdl.handle.net/11343/265775 Hardy, T; Howe, J 2011 Submission by the Centre for Employment and Labour Relations Law to the Australian Building and Construction Commission Inquiry into Sham Contracting Submission by the Centre for Employment and Labour Relations Law to the Australian Building and Construction Commission Inquiry into Sham Contracting Report 2011-01-01T00:00:00Z http://hdl.handle.net/11343/265774 Hardy, T; Howe, J; NEWMAN, A 2012 Submission by the Centre for Employment and Labour Relations Law to the Independent Inquiry into Insecure Work in Australia Submission by the Centre for Employment and Labour Relations Law to the Independent Inquiry into Insecure Work in Australia Report 2012-01-01T00:00:00Z http://hdl.handle.net/11343/265773 Howe, J; Chapman, A; Hardy, T 2012 Submission to the Fair Work Act Review Report 2012-01-01T00:00:00Z http://hdl.handle.net/11343/265772 Hardy, T; Howe, J; LANDAU, I; CHAPMAN, A; Gaze, B; Patmore, G; Orifici, A 2015 Response to the Draft Report of the Productivity Commission Inquiry into the Workplace Relations Framework Response to the Draft Report of the Productivity Commission Inquiry into the Workplace Relations Framework Report 2015-01-01T00:00:00Z http://hdl.handle.net/11343/265771 Hardy, T 2015 Submission to the Senate Inquiry into the Impact of Australia’s Temporary Work Visa Programs on the Australian Labour Market and on the Temporary Work Visa Holders Submission to the Senate Inquiry into the Impact of Australia’s Temporary Work Visa Programs on the Australian Labour Market and on the Temporary Work Visa Holders Report 2015-01-01T00:00:00Z http://hdl.handle.net/11343/265770 Hardy, T; TRANFAGLIA, MA; Howe, J 2016 Submission to the Victorian Inquiry into the Labour Hire Industry and Insecure Work Submission to the Victorian Inquiry into the Labour Hire Industry and Insecure Work Report 2016-01-01T00:00:00Z http://hdl.handle.net/11343/265769 Hardy, T 2017 Submission to the Senate Inquiry into the Impact of Non-Payment of the Superannuation Guarantee Submission to the Senate Inquiry into the Impact of Non-Payment of the Superannuation Guarantee Report 2017-01-01T00:00:00Z http://hdl.handle.net/11343/265768 Hardy, T; Tham, J-C 2017 Submission to the Senate Education and Employment Legislation Committee into the Fair Work Amendment (Protecting Vulnerable Workers) Bill 2017 Submission to the Senate Education and Employment Legislation Committee into the Fair Work Amendment (Protecting Vulnerable Workers) Bill 2017 Report 2017-01-01T00:00:00Z http://hdl.handle.net/11343/265767 Hardy, T 2018 Submission to the Senate Inquiry into the Operation and Effectiveness of the Franchising Code of Conduct Submission to the Senate Inquiry into the Operation and Effectiveness of the Franchising Code of Conduct Report 2018-01-01T00:00:00Z http://hdl.handle.net/11343/265766 Hardy, T; Stewart, A 2018 Submission to the Senate Inquiry into the Exploitation of General and Specialist Cleaners Working in Retail Chains for Contracting or Subcontracting Cleaning Companies Submission to the Senate Inquiry into the Exploitation of General and Specialist Cleaners Working in Retail Chains for Contracting or Subcontracting Cleaning Companies Report 2018-01-01T00:00:00Z http://hdl.handle.net/11343/265765 Kennedy, M; Howe, J; Hardy, T 2018 Submission to the Queensland Education, Employment and Small Business Committee Inquiry into Wage Theft in Queensland Submission to the Queensland Education, Employment and Small Business Committee Inquiry into Wage Theft in Queensland Report 2018-01-01T00:00:00Z http://hdl.handle.net/11343/265764 Hardy, T; McCrystal, S 2018 Submission to the Australian Competition and Consumer Commission Investigation into the Collective Bargaining Class Exemption Submission to the Australian Competition and Consumer Commission Investigation into the Collective Bargaining Class Exemption Report 2018-01-01T00:00:00Z http://hdl.handle.net/11343/265763 Hardy, T; Kennedy, M 2019 Submission to the Western Australian Department of Mines, Industry Regulation and Safety Inquiry into Wage Theft in Western Australia Submission to the Western Australian Department of Mines, Industry Regulation and Safety Inquiry into Wage Theft in Western Australia Report 2019-01-01T00:00:00Z http://hdl.handle.net/11343/265762 Hardy, T 2019 Submission to the Attorney-General Consultation on Industrial Relations, ‘Discussion Paper - Improving Protections of Employees’ Wages and Entitlements: Strengthening Penalties for Non-Compliance Submission to the Attorney-General Consultation on Industrial Relations, ‘Discussion Paper - Improving Protections of Employees’ Wages and Entitlements: Strengthening Penalties for Non-Compliance Report 2019-01-01T00:00:00Z http://hdl.handle.net/11343/265761 Hardy, T 2020 Submission to the Senate Economics Committee Inquiry into Unlawful Underpayment of Employees’ Remuneration Submission to the Senate Economics Committee Inquiry into Unlawful Underpayment of Employees’ Remuneration Report 2020-01-01T00:00:00Z http://hdl.handle.net/11343/265760 Hardy, T; Stewart, A; McCrystal, S; Riley Munton, J; Orifici, A 2021 Submission to the Senate Education and Employment Legislation Committee Inquiry into the Fair Work Amendment (Supporting Australia’s Jobs and Economic Recovery) Bill 2020 Submission to the Senate Education and Employment Legislation Committee Inquiry into the Fair Work Amendment (Supporting Australia’s Jobs and Economic Recovery) Bill 2020 Report 2021-01-01T00:00:00Z http://hdl.handle.net/11343/265759 Hardy, T; Johnstone, R; Howe, J 2019 Emerging Business Models and the Evolving Regulatory Response: Perspectives from Australia and Beyond This Special Issue contains a selection of articles presented at a workshop, ‘Emerging Business Models and the Evolving Regulatory Response: Perspectives from Australia and Beyond’. This workshop brought together a group of scholars, policymakers and graduate students actively working on, or otherwise interested in, the broad themes of labour and employment regulation and enforcement. The workshop was held in July 2018, with the generous support of the Centre for Employment and Labour Relations Law at the University of Melbourne. Journal Article 2019-01-01T00:00:00Z http://hdl.handle.net/11343/265758 Hardy, T 2007 Protection of Employees in a Transmission of Business: What is Left in the Wake of Work Choices and Subsequent Statutory Amendments Regulation of the employment relationship in the context of a transmission of business has undergone substantial revision as a result of the Workplace Relations Amendment (WorkChoices) Act 2005 (Cth), and more recently, the Workplace Relations Amendment (A Stronger Safety Net) Act 2007 (Cth). The first part of this paper reviews the statutory treatment of transmission of business in the past and considers the traditional justification for regulatory intervention in this area. The focus then turns to a detailed examination of the new statutory provisions and analyses the possible impetus for the changes, as well as identifying potential shortcomings. Finally, it looks at recent amendments relating to the application of duress in connection with Australian Workplace Agreements. It is argued that, despite the growing body of case law in this area, statutory intervention was necessary in order to ensure that, in a transmission of business, the obligations of employers were clearly prescribed and the market position of employees was properly protected. Report 2007-01-01T00:00:00Z http://hdl.handle.net/11343/265757 Hardy, T; Ariyawansa, S 2019 Literature Review on the Governance of Work egimes of governance: international, regional and national; or, private and public?  How can private and public governance best be combined so as to reinforce each other?  What new institutions and modes of governance might be needed? Report 2019-01-01T00:00:00Z http://hdl.handle.net/11343/265756 Landau, I; Cooney, S; Hardy, T; HOWE, J 2014-01-01 Trade Unions and the Enforcement of Minimum Employment Standards in Australia: Research Report Report 2014-01-01T00:00:00Z http://hdl.handle.net/11343/265755 HOWE, J; Hardy, T; Cooney, S 2014-01-01 The Transformation of Enforcement of Minimum Employment Standards in Australia: A Review of the Fair Work Ombudsman's Activities from 2006-2012 Report 2014-01-01T00:00:00Z http://hdl.handle.net/11343/265754 Hardy, T 2015 Literature Review for Research Project on the Interaction of Labour Inspection and Compliance Initiatives Report 2015-01-01T00:00:00Z http://hdl.handle.net/11343/265753 Dupper, O; Fenwick, C; Hardy, T 2016 The Interaction of Labour Inspection and Private Compliance Initiatives: A Case Study of Better Work Indonesia Report 2016-01-01T00:00:00Z http://hdl.handle.net/11343/265752 HOWE, J; Hardy, T 2017 Business Responses to Fair Work Ombudsman Compliance Activities: Research Report Report 2017-01-01T00:00:00Z http://hdl.handle.net/11343/265751 2021 Australian Slavonic and East European Studies Editorship 2021-01-01T00:00:00Z http://hdl.handle.net/11343/265750 Hardy, T 2005 Left Out in the Cold: Homelessness and Anti-Discrimination Law Anti-discrimination legislation has long been accepted as an integral part of Australian law and culture. However, the current legal framework at both Commonwealth and State levels fails to adequately protect people who are homeless, unemployed or in receipt of social security benefits. (1) This omission in the law masks the fact that discrimination against these groups is deeply ingrained and currently lawful. Not only does this seem to indicate a lack of awareness on the part of the legislature, it also seems to demonstrate ignorance of the fact that homeless people, although impoverished, possess basic human rights. Journal Article 2005-01-01T00:00:00Z http://hdl.handle.net/11343/265749 Hardy, T; Cooney, S; Howe, J 2013 Mandate, Discretion, and Professionalisation in an Employment Standards Enforcement Agency: An Antipodean Experience Journal Article 2013-01-01T00:00:00Z http://hdl.handle.net/11343/265748 Doughty, Larissa 2020 Discovering inhibitors of cell surface receptor function as the basis for novel therapeutics to treat cancer As our understanding of the molecular changes that trigger and potentiate cancer increases, cancer therapies are becoming increasingly refined and specifically targeted to increase efficacy and reduce side effects. Structure-based rational drug design has become a common method to identify lead compounds that can be further optimised as potential drug candidates. Cell-surface receptors that undergo changes in expression and activity in cancer and can be manipulated to elicit a therapeutic effect by a binding ligand that affects protein function make ideal targets. CD33 is a transmembrane protein from the sialic acid-binding immunoglobulin like lectin (siglec) family. It is expressed on the leukemic blasts from the majority of patients with acute myeloid leukemia (AML) but is not expressed on normal stem cells. CD33 also undergoes endocytosis when bound by CD33 antibodies. This expression pattern and the ability to potentially internalise a cytotoxic compound into the cancer cell implicates CD33 as a target for therapeutic intervention. Another cell surface receptor, CD151, from the tetraspanin family of proteins, has been shown to be over expressed in a variety of cancers. CD151 and its binding partner integrin, are key signalling proteins in cell motility and adhesion, which is a driver for cancer metastasis. Prostate cancer, which is only lethal once metastasised, could be effectively treated if metastasis could be controlled. Targeting the specific interaction between CD151 and integrin by inhibiting the unique CD151-integrin binding site has been shown to inhibit cell motility in cell based assays and is a promising target for small-molecule inhibitors. The specific aims of this thesis are to explore structural and functional aspects of CD33 and CD151, that are validated targets for certain cancers. Insights into the structure of these proteins will be used to identify small molecules that modulate protein function to develop novel strategies to treat common cancers in humans. © 2020 Larissa Doughty PhD thesis 2020-01-01T00:00:00Z http://hdl.handle.net/11343/265747 Zhu, Shiying 2020 In-cell Structure Determination of an Antimicrobial Peptide by DNP solid-state NMR Antibiotic resistance is a global threat to public health due to a combination of limited new antibiotic candidates and the dramatic rise in multidrug-resistant bacteria. Antimicrobial peptides (AMPs) are part of the host innate immune system and are potential alternatives to treat infections is increasing. AMPs have multiple modes of action to kill bacteria, mostly involving non-stereo specific interactions which drastically diminishe acquired-resistance pressure. For instance, one of the typical mechanisms is to target the bacterial cell membrane via electrostatic interactions and disrupt the lipid bilayer integrity. Maculatin 1.1 (Mac1, GLFGVLAKVAAHVVPAIAEHF-NH2) is a cationic membrane-active AMP, isolated from the skin of Australian tree frogs and well-known for its antibacterial ability. The molecular mechanism of Mac1 interaction with bacterial membranes has been mainly studied in vitro using model membrane systems. Although providing critical insights into the lipid-peptide interactions, it is unclear if the peptide retains a similar behaviour against bacterial membrane. Indeed, while the details of how Mac1 assembles into a lipid bilayer, and the lipid composition of model membranes have been shown to play a critical role in the peptide activity. Thus, investigating Mac1 structural arrangement in intact bacteria is an important step towards deciphering how AMPs may interact in situ. Solid-state NMR (ssNMR) is able to reveal structural behaviour of AMP in vitro, but its application is limited in vivo, especially due to the short life span of bacteria. Recent developments in dynamic nuclear polarization (DNP) ssNMR has led to the feasibility to conduct in-cell experiments due to higher sensitivity and longer cell survival rates. Spin probes together with isotope enriched peptides are required for DNP ssNMR experiment. In this thesis, the methodology to determine the structural arrangement of Mac1 in live bacteria by DNP-ssNMR is developed and the initial steps in understanding how AMPs self-assemble will be described. © 2020 Shiying Zhu PhD thesis 2020-01-01T00:00:00Z