http://hdl.handle.net/11343/159 2021-05-05T18:52:51Z http://hdl.handle.net/11343/273334 O'Flynn, J 2020-09-21 Confronting the big challenges of our time: making a difference during and after COVID-19 This article explores key challenges emanating from COVID-19 and how public management and administration research can contribute to addressing them. To do this I discuss the ‘big questions’ debate and then sketch two big thematic challenges. In articulating these, I point to interconnections across various levels of analysis and argue we need to work across a range of boundaries and get more comfortable with complexity. My key argument being that both during and in the aftermath of a catastrophic global pandemic, it is at the intersections, not in silos, that we are likely to move forward intellectually and practically. Journal Article 2020-09-21T00:00:00Z http://hdl.handle.net/11343/273333 O'Flynn, J 2020 Collaborating After Crisis: How Public Administration Scholars and Practitioners Can Work Together. Key Points This Policy Brief makes the following key points: (a) COVID-19 has laid bare the capacity challenges faced by governments and exacerbated entrenched disadvantage and inequality. The pandemic has acted as an accelerant of many problems that confront governments, shining light on how decades of reform have eroded government capacity and bought to the fore deep divisions in society. (b) Practitioners and scholars can work together on big challenges that confront us during the crisis and in the aftermath. We need a pivot from ‘big questions’ towards ‘big challenges’, so that public administration and management scholars can work closely with practitioners to address these challenges in real time. (c) To make a difference we need new ways of working collaboratively. If we are keen to collaborate in this crisis and beyond it makes more sense to look to successful collaborations rather than dwell on supposed tensions between scholars and practitioners. Report 2020-01-01T00:00:00Z http://hdl.handle.net/11343/273332 Hassink, WHJ; Kalb, G; Meekes, J 2021-04-21 Regional Coronavirus Hotspots During the COVID-19 Outbreak in the Netherlands. We explore the impact of COVID-19 hotspots and regional lockdowns on the Dutch labour market during the outbreak of COVID-19. Using weekly administrative panel microdata for 50 per cent of Dutch employees until the end of March 2020, we study whether individual labour market outcomes, as measured by employment, working hours and hourly wages, were more strongly affected in provinces where COVID-19 confirmed cases, hospitalizations and mortality were relatively high. The evidence suggests that labour market outcomes were negatively affected in all regions and local higher virus case numbers did not reinforce this decline. This suggests that preventive health measures should be at the regional level, isolating hotspots from low-risk areas. Journal Article 2021-04-21T00:00:00Z http://hdl.handle.net/11343/273331 Mohammadi, Hiwa 2020 Stress interactions in intraplate earthquakes Australia is a seismically active continent with an intraplate compressive stress field primarily driven by far-field plate boundary interactions. Major (magnitude >= 5) surface-rupturing earthquakes are primarily sourced from reverse faults. Major earthquakes perturb local-to-regional stress fields and influence the spatiotemporal properties of subsequent earthquakes. This thesis first contextualizes Australian earthquakes against global comparatives by investigating 260 finite-fault rupture models for 137 moment magnitude (Mw) 4.1 to 8.1 continental earthquakes worldwide. I find that: (i) Australian earthquakes are amongst the most kinematically and geometrically complex for their Mw, (ii) upper-bounds and variance of the number of faults that rupture co-seismically increase with increasing Mw, and (iii) multi-fault rupture populations show no dependency on strain rate or proximity to plate boundaries. The thesis then presents a suite of studies that model static and viscoelastic coulomb stress changes (dCFS) imparted by major Australian earthquakes on to receiver faults and in the surrounding crust. I find that static dCFS models provide an informative physical-statistical basis for characterising many seismic sequences in Australia, with some exceptions. Aftershocks occur predominantly within positive static stress lobes and close to the advancing viscoelastic positive stress lobes, especially over the first few decades after major earthquakes in these regions. Earthquake triggering appears to occur under stress perturbations as small as approx 0.001 to 0.01 bar, suggesting cratons contain regions of critically stressed lithosphere. The effects of varying source fault geometries and kinematics on dCFS fields and subsequent seismicity are used to show how progressive refinement of source fault models using emergent data can reduce epistemic uncertainties in the role of dCFS in earthquake triggering. In some instances, increased source model complexity does not significantly impact on dCFS results and possible relationships to aftershocks relative to simple source models. The thesis finally investigates the role of lithospheric-scale flexural bending due to eustatic sea level changes, and whether these impart dCFS perturbations on finite faults and in regions similarly to stresses imparted by preceding earthquakes. Preliminary age distributions of large paleo-earthquakes on these reverse faults are concurrent with dCFS peaks imparted by eustatic sea-level changes. dCFS of > 0.1 to > 1 bar on faults during the low-stand Marine Isotope (MIS) Stage 2 to Stage 4 interval (ca. approx 30 to approx. 70 ka) provides tentative evidence that earthquake clusters could be stimulated by sea-level lowstands. This thesis demonstrates the power and utility of dCFS modelling to improve understanding of intraplate earthquakes. © 2020 Hiwa Mohammadi PhD thesis 2020-01-01T00:00:00Z http://hdl.handle.net/11343/273330 Subba, Maita 2020 Investigating freshwater snails Potamopyrgus antipodarum as a suitable test species for ecotoxicological testing of surface water in Australia Ecotoxicology studies the fate and effect of chemicals in the ecosystem using scientific approaches. Laboratory tests (e.g. acute and chronic tests) establish dose response relationships between toxicants and the test species. Although laboratory tests provide essential data to understand the potential impact of toxicants in the aquatic environment, they lack environmental realism. In situ tests provide environmental realism by exposing the test organism to toxicants in the aquatic environment. Test species are central in ecotoxicity assays. Molluscs are commonly used in ecotoxicological tests and they are the second largest phylum, have a global distribution, widely abundant in freshwaters, and ecological importance (e.g. as a food source, provides habitat and protection) makes them useful in ecotoxicity tests. This thesis used a freshwater snail, Potamopyrgus antipodarum (J.E. Gray, 1843), for laboratory and field testing. Although native to New Zealand, it is a successful invasive species in many parts of the world, including Australia and has been successfully used as a test species for ecotoxicity tests and as a bioindicator in some countries (e.g. in Europe, and the USA). A few Australian studies have used it in laboratory assays and field studies. There is still less knowledge and information of P. antipodarum as a test species and bioindicator in Australia. Therefore, the overall aim of the thesis is to assess the potential of P. antipodarum as a bioindicator of freshwater pollution in Australia. In Chapter 2, adult P. antipodarum were exposed (96 h) to environmentally relevant concentrations (ERCs) of metals (copper and zinc) and a pesticide (imidacloprid) in water. Mortality (LC50) and behavioural responses (EC50) were assessed to investigate the sensitivity of the snail and the potential use of its behavioural response in the environmental risk assessment of toxicants. The Chapter 3 was an extension of the Chapter 2 to assess their sensitivity in chronic toxicity tests. Adult snails were exposed for 28-d to ERCs of several chemicals (Cu, Zn, bifenthrin, and 17 a-ethynylestradiol), physico-chemical conditions (salinity and temperature), and food limitation in water and sediment bioassays. Endpoints including reproduction, growth, and mortality were measured. This study evaluated the sensitivity of this species during chronic exposure and compared the response of these Australian cultures to those abroad. In Chapter 4, adult snails were deployed in cages in the field for 28-d at 9 sites (i.e. 7 impact sites, and 2 reference sites) in Merri Creek and an additional reference site in Cardinia Creek to evaluate the performance of snails at various points along Merri Creek with different land use. Various endpoints were measured at the organism level (growth, mortality and reproduction), and the sub-organism level (glutathione Stransferase, GST; lipid peroxidation, LPO; and catalase, CAT). The biological response of the snails at each impact site were compared to the 2 reference sites on Merri Creek to show the potential impact of land use on the snails. The additional reference site at Cardiana Creek was compared with the reference sites on Merri Creek to identify any difference in response in a different catchment. This project shows that P. antipodarum is a suitable and sensitive species for acute and chronic assays because it responded to ERCs of toxicants, the response is like populations abroad, it showed a similar response to other test species and LC50 and EC50 value was within the range of other test species in use. There is potential to use acute tests (LC50) and behavioural responses (EC50) in the rapid risk assessment of environmental pollutants. Field data also revealed that P. antipodarum is a suitable bioindicator for Australian environmental conditions because the response of this population was similar to the populations abroad, and other test species used in in situ tests and showed a high tolerance to environmental variations. This research also shows that although laboratory tests can provide us with essential data to understand the potential impact of toxicants in the aquatic environment, they lack environmental realism. And we can achieve environmental realism by exposing the species to toxicants in the aquatic environment during in situ tests. © 2020 Maita Subba PhD thesis 2020-01-01T00:00:00Z http://hdl.handle.net/11343/273329 Krohn, Jo-Frederik 2021 Measurement of the branching fractions of $\bar{B}^{0}\to D^{*+} h^{-}$ decays at the Belle experiment and development of a global particle vertex fitting algorithm for Belle~II In this thesis high precision QCD-factorisation tests were performed. The branching ratios $\mathcal{B}(\bar{B}^0 \to D^{*+} \pi^-) = \brpioncombabs$ and $\mathcal{B}(\bar{B}^0 \to D^{*+} K^-) = \brkaoncombabs$ were measured using $(771.58 \pm 10.56) \times 10^6$ $B$-meson pairs recorded by the Belle experiment. Both values are in tension with the theoretical expectation. The ratio of the branching ratio is measured in a way that allows for the cancellation of the systematic uncertainties arising from the $D^{*}$-meson reconstruction; the value of $\mathcal{R}_{K/\pi}=\mathcal{B}(\bar{B} \to D^{*+}K^-) /\mathcal{B}( \bar{B} \to D^{*+}\pi^-) = \ratiocombabs$ was found. Both $\mathcal{B}(\bar{B}^0 \to D^{*+} \pi^-)$ and $\mathcal{B}(\bar{B}^0 \to D^{*+} K^-)$ have shown deviations from the prediction, this suggests that the estimation of the Feynman diagrams contributing to the predictions may be inaccurate. The new measured branching ratios were used to perform a high precision QCD factorisation test by measuring ratios with respect to semi-leptonic branching ratios at fixed momentum transfers for different particle species. A deviation for the ratio $\Gamma(\bar{B}^0 \to D^{*+} h^-)/d\Gamma(\bar{B}^0 \to D^{*+} l^-\bar{\nu})/dq^2$ of $16\%$ from theoretical predictions was found, suggesting large non-factorisable contributions and/or new physics contributions. Furthermore, $SU(3)$-symmetry was tested by measuring ratios for pions and kaons of $a_1^2(K)/ a_1^2(\pi)=\aoneratioabs$ as well as for different particle species. The found value is consistent with unity and therefore no evidence for $SU(3)$-symmetry breaking effects was found in this test to $5\%$ precision. Thus, for $ \mathcal{R}_{K/\pi}$ one can rule out $SU(3)$-symmetry breaking effects as an explanation for the deviation. Finally, a new vertex fitting algorithm and its implementation for the Belle~II software framework was reported. It can improve $D^*$-meson reconstruction, is computationally very efficient and is now the standard vertex fitting tool of the Belle~II experiment. © 2021 Jo-Frederik Krohn PhD thesis 2021-01-01T00:00:00Z http://hdl.handle.net/11343/273328 Jackson, Phyllis Joy 2021 Practices of professionalism in Early Childhood Education and Care: Long day care educators at work There is an emerging corpus of Australian research, both qualitative and quantitative, inquiring into how early childhood education and care (ECEC) educators experience and understand their work. This qualitative case study traces the lived experience of a group of centre-based long day care educators working in communities experiencing high levels of social and economic disadvantage. Set within the context of the Australian ECEC reform program, the study investigates what constitutes ECEC professionalism and how educators experience and practise it every day. Analysing data drawn from two quality centre-based long day care settings, it was found that educators predominantly frame professionalism in terms of pedagogic practice—what they do, how they use their knowledge and skills and how they enact professional identities they value. Thus, for many of the study’s participants, a commitment to social justice, of wanting to make a difference in the lives of young children and their families and, a belief in quality ECEC services as having the potential to ameliorate the socio-economic inequities many families in their community experience, was the basis on which their practice and professionalism was constructed. Altogether, the argument is made that educators’ understandings of their work practice, value commitments and the qualities and dispositions they privilege offer a nuanced and multifaceted view of professionalism, one that potentially widens the policy-based discourse of ECEC professionalism and requires that acknowledgement be made of the range and complexity of educators’ work in contemporary ECEC. The identity(ies) of relational and ethical professionalism that is both child-centred and family and community-centred most particularly requires recognition and support. © 2021 Phyllis Joy Jackson Doctorate; thesis 2021-01-01T00:00:00Z http://hdl.handle.net/11343/273327 Murthi, P; Brennecke, SP 2020-10-25 The placenta is the villain or victim in the pathogenesis of pre-eclampsia Journal Article 2020-10-25T00:00:00Z http://hdl.handle.net/11343/273326 Ekawati, FM; Emilia, O; Brennecke, S; Gunn, J; Licqurish, S; Lau, P 2020-01-01 Opportunities for improving hypertensive disorders of pregnancy (HDP) management in primary care settings: A review of international published guidelines in the context of pregnancy care in Indonesia Almost all of global maternal mortality caused by HDP occurs in low to middle-income countries (LMIC). However, limited guidance is available to local primary care practitioners who are usually the main health care providers. This review examined existing international practice guidelines to identify potential practices to improve HDP management in Indonesian primary care settings. We performed structured literature search strategies and snowballing searches in six databases (MEDLINE, Web of Science, EMBASE, CINAHL, Cochrane reviews and Google Scholar) for guidelines that were published between 2007 and 2018 using relevant keywords and phrases of ‘guidelines’, ‘hypertensive disorders of pregnancy’ or ‘preeclampsia’ and ‘primary care’. The AGREE II instrument was used to assess quality and reporting of the eligible guidelines. Thematic analysis was performed on all of the guidelines and the results were discussed among the project investigators. Sixteen international practice guidelines or similar management recommendations were reviewed. Almost all of them were partially applicable, with some managements potentially able to be adopted to Indonesian primary care settings. Three main themes for improving HDP management were identified, namely clinical management, care planning, and professional communication. These potential improvements in managing women with HDP in Indonesia may also be relevant in other LMIC. Further contextualisation is required to facilitate their adoption in practice settings. Journal Article 2020-01-01T00:00:00Z http://hdl.handle.net/11343/273325 East, CE; Davey, M-A; Kamlin, COF; Davis, PG; Sheehan, PM; Kane, SC; Brennecke, SP 2021-03-23 The addition of fetal scalp blood lactate measurement as an adjunct to cardiotocography to reduce caesarean sections during labour: The Flamingo randomised controlled trial BACKGROUND: Fetal scalp blood sampling for lactate measurement (FBSLM) is sometimes used to assist in identification of the need for expedited birth in the presence of an abnormal cardiotocograph (CTG). However, there is no randomised controlled trial evidence to support this. AIM: To determine whether adding FBSLM reduces the risk of birth by emergency caesarean section in labours complicated by an abnormal CTG, compared with CTG without FBS. MATERIAL AND METHODS: Labouring women at a tertiary maternity hospital in Melbourne, Australia with a singleton, cephalic presentation, at ≥37 weeks gestation with an abnormal CTG pattern were randomised to the intervention (n = 61), with intermittent FBSLM in addition to CTG monitoring, or control (CTG without FBS, n = 62). The primary outcome was rate of birth by caesarean section. Secondary outcomes included overall operative birth and fetal and neonatal safety endpoints. TRIAL REGISTRATION: ACTRN12611000172909. RESULTS: The smaller than anticipated sample was unable to demonstrate an effect from adding FBSLM to CTG monitoring on birth by caesarean section vs monitoring by CTG without FBS (25/61 and 28/62 respectively, P = 0.64, risk ratio 0.91, 95% confidence intervals 0.60-1.36). One newborn infant in the CTG group met the criteria for the composite neonatal outcome of death or serious outcome, neonatal encephalopathy, five-minute Apgar score < 4, neonatal resuscitation, admission to neonatal intensive care unit for 96 h or more. CONCLUSION: We were unable to provide robust evidence of the effectiveness of FBSLM to improve the specificity of the CTG in the assessment of fetal wellbeing. Journal Article 2021-03-23T00:00:00Z http://hdl.handle.net/11343/273324 Black, C; Rolnik, DL; Al-Amin, A; Kane, SC; Stolarek, C; White, A; Da Silva Costa, F; Brennecke, S 2020-03-02 Prediction of preterm pre-eclampsia at midpregnancy using a multivariable screening algorithm BACKGROUND: Competing risk models used for midpregnancy prediction of preterm pre-eclampsia have shown detection rates (DR) of 85%, at fixed false-positive rate (FPR) of 10%. The full algorithm used between 19+0 and 24+6  weeks includes maternal factors, mean arterial pressure (MAP), mean uterine artery pulsatility index (UtAPI), serum placental growth factor (PlGF) level in multiples of the median (MoM), and soluble Fms-like tyrosine kinase-1 (sFlt-1) level in MoM. AIMS: To assess performance of the Fetal Medicine Foundation (FMF) algorithm at midpregnancy to screen for preterm (<37 weeks) pre-eclampsia. The outcome measured was preterm pre-eclampsia. MATERIALS AND METHODS: This is a prospective study including singleton pregnancies at 19-22 weeks gestation. Maternal bloods were collected and analysed using three different immunoassay platforms. Maternal characteristics, medical history, MAP, mean UtAPI, serum PlGF MoM and serum sFlt-1 MoM were used for risk assessment. DR and FPR were calculated, and receiver operating characteristic curves produced. RESULTS: Five hundred and twelve patients were included. Incidence of preterm pre-eclampsia was 1.6%. Using predicted risk of pre-eclampsia of one in 60 or more and one in 100 or higher, as given by the FMF predictive algorithm, the combination with the best predictive performance for preterm pre-eclampsia included maternal factors, MAP, UtAPI and PlGF MoM, giving DRs of 100% and 100%, respectively, and FPRs of 9.3 for all platforms and 12.9-13.5, respectively. Addition of sFlt-1 to the algorithm did not appear to improve performance. sFlt-1 MoM and PlGF MoM values obtained on the different platforms performed very similarly. CONCLUSIONS: Second trimester combined screening for preterm pre-eclampsia by maternal history, MAP, mean UtAPI and PlGF MoM using the FMF algorithm performed very well in this patient population. Journal Article 2020-03-02T00:00:00Z http://hdl.handle.net/11343/273323 Siriwardhana, R; Tonta, MA; Sheehan, PM; Coleman, HA; Brennecke, SP; Parkington, HC 2020-03-01 New Insights into the Nature and Role of Potassium Channels in Regulating Uterine Contraction in Human Labour. Conference Paper 2020-03-01T00:00:00Z http://hdl.handle.net/11343/273322 Parkington, HC; Sheehan, PM; Coleman, HA; Brennecke, SP 2020-05-18 NO placental inflammation Journal Article 2020-05-18T00:00:00Z http://hdl.handle.net/11343/273321 Ekawati, FM; Licqurish, S; Gunn, J; Brennecke, S; Lau, P 2021-04-01 Hypertensive disorders of pregnancy (HDP) management pathways: results of a Delphi survey to contextualise international recommendations for Indonesian primary care settings BACKGROUND: Hypertensive disorders of pregnancy (HDP) are a significant contributor to the high maternal mortality rate in Indonesia. At the moment, limited guidelines are available to assist primary care providers in managing HDP cases. A previous review of 16 international HDP guidelines has identified opportunities for improving HDP management in Indonesian primary care, but it has not determined the suitability of the recommendations in practice. This study aims to achieve consensus among the experts regarding the recommendations suitability and to develop HDP pathways in Indonesian primary care. METHODS: Maternal health experts, including GPs, midwives, nurses, medical specialists and health policy researchers from Indonesia and overseas were recruited for the study. They participated in a consensus development process that applied a mix of quantitative and qualitative questions in three Delphi survey rounds. At the first and second-round survey, the participants were asked to rate their agreement on whether each of 125 statements about HDP and HDP management is appropriate for use in Indonesian primary care settings. The third-round survey presented the drafts of HDP pathways and sought participants' agreement and further suggestions. The participants' agreement scores were calculated with a statement needing a minimum of 70% agreement to be included in the HDP pathways. The participants' responses and suggestions to the free text questions were analysed thematically. RESULTS: A total of 52 participants were included, with 48, 45 and 37 of them completing the first, second and third round of the survey respectively. Consensus was reached for 115 of the 125 statements on HDP definition, screening, management and long-term follow-up. Agreement scores for the statements ranged from 70.8-100.0%, and potential implementation barriers of the pathways were identified. Drafts of HDP management pathways were also agreed upon and received suggestions from the participants. CONCLUSIONS: Most evidence-based management recommendations achieved consensus and were included in the developed HDP management pathways, which can potentially be implemented in Indonesian settings. Further investigations are needed to explore the acceptability and feasibility of the developed HDP pathways in primary care practice. Journal Article 2021-04-01T00:00:00Z http://hdl.handle.net/11343/273320 Chang, JJ-Y; Rawlinson, D; Pitt, ME; Taiaroa, G; Gleeson, J; Zhou, C; Mordant, FL; De Paoli-Iseppi, R; Caly, L; Purcell, DFJ; Stinear, TP; Londrigan, SL; Clark, MB; Williamson, DA; Subbarao, K; Coin, LJM 2021-04 Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infection Journal Article 2021-04-01T00:00:00Z http://hdl.handle.net/11343/273319 Dong, X; Tian, L; Gouil, Q; Kariyawasam, H; Su, S; De Paoli-Iseppi, R; Prawer, YDJ; Clark, MB; Breslin, K; Iminitoff, M; Blewitt, ME; Law, CW; Ritchie, ME 2021-06 The long and the short of it: unlocking nanopore long-read RNA sequencing data with short-read differential expression analysis tools. Application of Oxford Nanopore Technologies' long-read sequencing platform to transcriptomic analysis is increasing in popularity. However, such analysis can be challenging due to the high sequence error and small library sizes, which decreases quantification accuracy and reduces power for statistical testing. Here, we report the analysis of two nanopore RNA-seq datasets with the goal of obtaining gene- and isoform-level differential expression information. A dataset of synthetic, spliced, spike-in RNAs ('sequins') as well as a mouse neural stem cell dataset from samples with a null mutation of the epigenetic regulator Smchd1 was analysed using a mix of long-read specific tools for preprocessing together with established short-read RNA-seq methods for downstream analysis. We used limma-voom to perform differential gene expression analysis, and the novel FLAMES pipeline to perform isoform identification and quantification, followed by DRIMSeq and limma-diffSplice (with stageR) to perform differential transcript usage analysis. We compared results from the sequins dataset to the ground truth, and results of the mouse dataset to a previous short-read study on equivalent samples. Overall, our work shows that transcriptomic analysis of long-read nanopore data using long-read specific preprocessing methods together with short-read differential expression methods and software that are already in wide use can yield meaningful results. Journal Article 2021-06-01T00:00:00Z http://hdl.handle.net/11343/273318 Chua, CLL; Hasang, W; Rogerson, SJ; Teo, A 2021-03-15 Poor Birth Outcomes in Malaria in Pregnancy: Recent Insights Into Mechanisms and Prevention Approaches Pregnant women in malaria-endemic regions are susceptible to malaria in pregnancy, which has adverse consequences on birth outcomes, including having small for gestational age and preterm babies. These babies are likely to have low birthweights, which predisposes to infant mortality and lifelong morbidities. During malaria in pregnancy, Plasmodium falciparum-infected erythrocytes express a unique variant surface antigen, VAR2CSA, that mediates sequestration in the placenta. This process may initiate a range of host responses that contribute to placental inflammation and dysregulated placental development, which affects placental vasculogenesis, angiogenesis and nutrient transport. Collectively, these result in the impairment of placental functions, affecting fetal development. In this review, we provide an overview of malaria in pregnancy and the different pathological pathways leading to malaria in pregnancy-associated low birthweight. We also discuss current prevention and management strategies for malaria in pregnancy, and some potential therapeutic interventions that may improve birth outcomes. Lastly, we outline some priorities for future research that could bring us one step closer to reducing this health burden. Journal Article 2021-03-15T00:00:00Z http://hdl.handle.net/11343/273317 Pate, KM; Pohlmeyer, C; Walker-Sperling, V; Foote, J; Najarro, K; Cryer, C; Salgado, M; Gama, L; Engle, E; Shirk, E; Queen, S; Chioma, S; Vermillion, M; Bullock, B; Li, M; Lyons, C; Adams, R; Zink, C; Clements, J; Mankowski, J; Blankson, J; Micci, L; Ryan, E; Fromentin, R; Benne, C; Chomont, N; Lifson, J; Paiardini, M; Lee, S; Chomont, N; Fromentin, R; Silicano, R; Silicano, J; Richman, D; O'Doherty, U; Palmer, S; Burbelo, P; Deeks, S; Ghneim, K; Ahlers, J; Fourati, S; Shive, C; Cameron, M; Mukerjee, P; Ghannoum, M; Rodriguez, B; Deeks, S; Lederman, M; Sekaly, R; Frange, P; Faye, A; Avettand-Fenoel, V; Bellaton, E; Deschamps, D; Angin, M; Caillat-Zucman, S; Peytavin, G; Le Chenadec, J; Warszawski, J; Rouzioux, C; Saez-Cirion, A; Chang, C; Cameron, P; Elliott, J; Perelson, A; Roche, M; Dantanarayana, A; Solomon, A; Naranbhai, V; Tenakoon, S; Hoh, R; McMahon, J; Sikaris, K; Hartogensis, W; Bacchetti, P; Hecht, F; Lifson, J; Deeks, S; Lewin, S; Byrareddy, S; Arthos, J; Cicala, C; Reimann, K; Parslow, T; Santangelo, P; Villinger, F; Fauci, A; Ansari, A; George, M; Weiser, B; Burger, H; Lewy, T; Anastos, K; Asmuth, D; Somsouk, M; Hunt, P; Min, Z; Miller, C; Li, XD; Hinkle, J; Shaw, A; Weaver, E; Klein, G; Viljoen, K; Wendoh, J; Karaoz, U; Brodie, E; Mulder, N; Botha, G; Kidzeru, E; Butcher, J; Gray, C; Rosenthal, K; Abimiku, A; Cameron, B; Stintzi, A; Jaspan, H; Schafer, J; Evans, T; Li, H; Reeves, RK; Kroon, M; Dunning, L; Hsiao, M; Myer, L; Crowell, CS; Maiga, AI; Sylla, M; Taiwo, B; Koné, N; Murphy, RL; Marcelin, A-G; Traore, B; Fofana, DB; Chadwick, EG; Ásbjörnsdóttir, KH; Slyker, JA; Wamalwa, D; De Rosa, S; Hughes, JP; Rowhani-Rahbar, A; Chohan, BH; Benki-Nugent, S; Tapia, K; John-Stewart, GC; Kizito, H; Gaur, A; Prasitsuebsai, W; Rakhmanina, N; Chokephaibulkit, K; Fourie, J; Bekker, L-G; Shao, Y; Bennett, S; Quirk, E; Prasitsuebsai, W; Teeraananchai, S; Truong, KH; Ananworanich, J; Chau, V; Van Nguyen, L; Kosalaraksa; Kurniati, N; Sudjaritruk, T; Chokephaibulkit, K; Singtoroj, T; Kerr, SJ; Sohn, AH; Lombaard, J; Bunupuradah, T; Flynn, P; Ramapuram, J; Ssali, F; Crauwels, H; Hoogstoel, A; Van Eygen, V; Stevens, M; Boven, K; Jao, J; Myer, L; Phillips, T; Petro, G; Zerbe, A; Abrams, EJ; Hanrahan, C; Martinson, N; Link-Barnes, G; Msandiwa, R; Chaisson, R; Golub, J; Evans, DH; Schnippel, K; Budgell, E; Shearer, K; Berhanu, R; Long, L; Rosen, S; Schultze, A; Efsen, AMW; Post, FA; Panteleev, A; Furrer, H; Miller, R; Losso, MH; Toibaro, J; Skrahin, A; Miro, JM; Caylà, JA; Girardi, E; Bruyand, M; Obel, N; Podlekareva, DN; Lundgren, JD; Mocroft, A; Kirk, O; Baddeley, A; Doherty, M; Kanchar, A; Matteelli, A; Timimi, HB; Getahun, H; Hosseinipour, M; Bisson, G; Miyahara, S; Sun, X; Moses, A; Riviere, C; Kirui, FK; Badal-Faesen, S; Lagat, D; Nyirenda, M; Naidoo, K; Hakim, J; Mugyenyi, P; Henostroza, G; Leger, PD; Lama, JR; Mohapi, L; Alave, J; Mave, V; Veloso, VG; Pillay, S; Kumarasamy, N; Bao, J; Hogg, E; Jones, L; Zolopa, A; Kumwenda, J; Gupta, A; Cohen, M; Chen, Y; McCauley, M; Gamble, T; Hosseinipour, M; Kumarasamy, N; Hakim, J; Kumwenda, N; Brum, T; Grinsztejn, B; Godbole, S; Chariyalertsak, S; Santos, RB; Mayer, K; Hoffman, I; Eshleman, S; Piwowar-Manning, E; Ou, S-S; Cottle, L; Makhema, J; Mills, L; Panchia, R; Badal-Faesen, S; Eron, J; Gallant, J; Havlir, D; Swindells, S; Elharrar, V; Burns, D; Taha, T; Nielsen, K; Celentano, D; Essex, M; Fleming, T; Jean, K; Puren, A; Cutler, E; Singh, B; Bouscaillou, J; Rain-Taljaard, R; Taljjard, D; Lissouba, P; Peytavin, G; Auvert, B; Jenkins, L; Nordio, J; Vasarhelyi, K; Nunez, A; Barrios, R; Rutherford, A; Iwuji, C; Dray-Spira, R; Calmy, A; Larmarange, J; Orne-Gliemann, J; Dabis, F; Pillay, D; Porter, K; Barnabas, R; van Rooyen, H; Tumwesigye, E; Brantley, J; Baeten, J; van Heerden, A; Turyamureeba, B; Joseph, P; Krows, M; Hughes, J; Celum, C; Eshleman, SH; Hudelson, SE; Ou, SS; Redd, AD; Swanstrom, R; Porcella, SF; Chen, YQ; Piwowar-Manning, E; McCauley, M; Gamble, T; Sievers, M; Martens, CA; Bruno, D; Ping, L-H; Dukhovlinova, E; Quinn, TC; Kumwenda, J; Maliwichi, M; Nhando, N; Akelo, V; Moyo, S; Panchia, R; Kumarasamy, N; Chotirosniramit, N; Rocha, MM; Bustorff, F; Grinsztejn, B; Mayer, KH; Hughes, JP; Cohen, MS; Haas, AD; Tenthani, L; Msukwa, MT; Jahn, A; Midiani, D; Mhango, E; Gadabu, O; Tal, K; Spörri, A; Egger, M; Chimbwandira, F; van Oosterhout, JJ; Keiser, O; Rosenberg, N; Mtande, T; Saidi, F; Stanley, C; Jere, E; Mwangomba, L; Kumwenda, K; Mofolo, I; Mwale, M; Chauma, A; Miller, WC; Hoffman, I; Hosseinipour, MC; Buzdugan, R; McCoy, SI; Watadzaushe, C; Dufour, M-SK; Petersen, M; Dirawo, J; Mushavi, A; Mujuru, HA; Mahomva, A; Engelsmann, B; Hakobyan, A; Mugurungi, O; Cowan, FM; Padian, NS; Lallemant, M; Amzal, B; Urien, S; Sripan, P; Cressey, T; Ngo-Giang-Huong, N; Rawangban, B; Sabsanong, P; Siriwachirachai, T; Jarupanich, T; Kanjanavikai, P; Wanasiri, P; Koetsawang, S; Jourdain, G; Le Cœur, S; Ochoa-Moreno, I; Mangenah, C; Buzdugan, R; Padian, NS; Mccoy, SI; Cowan, FM; Bautista-Arredondo, S; Wambura, M; Hayes, R; Grund, J; Kapiga, S; Mahler, H; Mshana, G; Kuringe, E; Plotkin, M; Bock, N; Larke, N; Changalucha, J; Weiss, H; Thirumurthy, H; Akello, I; Murray, K; Masters, S; Maman, S; Omanga, E; Agot, K; Duwve, J; Hoover, K; Conrad, C; Galang, R; Hillman, D; Hoots, B; Patel, M; Peters, P; Pontones, P; Roseberry, J; Shields, J; Waterhouse, D; Weidle, P; Galang, RR; Gentry, J; Peters, PJ; Blosser, SJ; Chapman, EL; Conrad, C; Duwve, JM; Ganova-Raeva, L; Heneine, W; Hillman, D; Jia, H; Liu, L; Luo, W; Lovchik, J; Masciotra, S; Owen, SM; Perez, A; Peyrani, P; Pontones, P; Ramachandran, S; Roseberry, JC; Sandoval, M; Shankar, A; Thai, H; Xia, G; Khudyakov, Y; Switzer, WM; Mannheimer, S; Hirsch-Moverman, Y; Loquere, A; Franks, J; Hughes, J; Ou, S-S; Amico, KR; Hendrix, C; Dye, BJ; Piwowar-Manning, E; Marzinke, M; Elharrar, V; Stirratt, M; Grant, RM; Holtz, TH; Chitwarakorn, A; Curlin, ME; Hughes, J; Amico, KR; Hendrix, C; Dye, BJ; Anderson, PL; Ou, S-S; Elharrar, V; Eshleman, SH; Stirratt, M; Grant, RM; Doherty, M; Beusenberg, M; Asamoah-Odei, E; Lule, F; Pendse, R; Ghidinelli, M; Lo, Y-R; Reidner, G; Donoghoe, M; Vitoria, M; Hirnschall, G; Levi, J; Raymond, A; Pozniak, A; Vernazza, P; Kohler, P; Ford, N; Hill, A; Wolff, M; Cortes, CP; Shepherd, BE; Giganti, M; Gowan, CM; Rawat, A; Uebel, KE; Moore, D; Yassi, A; Wilkinson, L; Harley, B; Jacobs, S; Cragg, C; Kriel, E; Solomon, S; Peton, N; Jennings, K; Youngleson, M; Grimsrud, A; Joy, J; Liang, R; McCloskey, R; Nguyen, T; Brumme, C; Colley, G; Hogg, R; Montaner, J; Harrigan, PR; Poon, A; Klein, K; Ratcliff, A; Nickel, G; Nankya, I; Lobritz, M; Gao, Y; Shattock, R; Arts, E; Kinloch, NN; Macmillan, DR; Le, AQ; Cotton, LA; Mccloskey, R; Bangsberg, DR; Buchbinder, S; Carrington, M; Fuchs, J; Harrigan, PR; Koblin, B; Markowitz, M; Mayer, K; Milloy, MJ; Schechter, MT; Wagner, T; Walker, BD; Carlson, JM; Poon, AFY; Brumme, ZL; Mesplède, T; Anstett, K; Osman, N; Hassounah, S; Liang, J; Han, Y; Wainberg, M; Demeulemeester, J; Vets, S; Schrijvers, R; Madlala, P; De Maeyer, M; De Rijck, J; Ndung'u, T; Debyser, Z; Gijsbers, R; Prentice, H; Tomaras, G; Geraghty, D; Apps, R; Fong, Y; Ehrenberg, P; Rolland, M; Kijak, G; Nelson, W; Decamp, A; Shen, X; Yates, N; Zolla-Pazner, S; Nitayaphan, S; Rerks-Ngarm, S; Pitisuttithum, P; Ferrari, G; Montefiori, D; McElrath, J; Bailer, R; Koup, R; O'Connell, R; Robb, M; Michael, N; Kim, J; Thomas, R; Peterson, C; Wang, J; Polacino, P; Holmes, M; Hu, S-L; Gregory, P; Kiem, H-P; Kaminski, R; Hu, W; Zhang, Y; Karn, J; Khalili, K; Chew, G; Fujita, T; Clayton, K; Ishii, N; Abdel-Mohsen, M; Liegler, T; Hecht, F; Ostrowski, M; Shikuma, C; Maurer, M; Korman, A; Deeks, S; Ndhlovu, L; Karn, J; Das, B; Dobrowolski, C; Scully, E; Deeks, S; Gandhi, M; Johnston, R; Bunupuradah, T; Kiertiburanakul, S; Avihingsanon, A; Chetchotisakd, P; Techapornroong, M; Leerattanapetch, N; Kantipong, P; Bowonwatanuwong, C; Banchongkit, S; Klinbuayaem, V; Mekviwattanawan, S; Nimitvilai, S; Jirajariyavej, S; Prasithsirikul, W; Munsakul, W; Bhakeecheep, S; Chaivooth, S; Phanuphak, P; Cooper, DA; Apornpong, T; Kerr, SJ; Emery, S; Ruxrungtham, K; Mills, T; Andrade, J; Diperri, G; Van Lunzen, J; Koenig, E; Elion, R; Cavassini, M; Madruga, JV; Brunetta, J; Shamblaw, D; Dejesus, E; Cohen, C; Plummer, A; Liu, Y; McCallister, S; Gupta, S; Pozniak, A; Arribas, J; Post, F; Bloch, M; Gathe, J; Benson, P; Custodio, J; Abram, M; Wei, X; Cheng, A; McCallister, S; Fordyce, M; Gatell, J; Raffi, F; Plettenberg, A; Smith, D; Portilla, J; Hoffmann, C; Arasteh, K; Thompson, M; Hagins, D; Morales-Ramirez, J; Xu, X; Teppler, H; Trahan, M-J; Lamarre, V; Metras, M-E; Lapointe, N; Kakkar, F; Hwang, C; Schürmann, D; Sobotha, C; Boffito, M; Sevinsky, H; Ray, N; Ravindran, P; Xiao, H; Krystal, M; Dicker, I; Grasela, D; Lataillade, M; Brunet, L; Moodie, EE; Young, J; Walmsley, S; Hull, M; Cooper, C; Klein, MB; Naggie, S; Cooper, C; Saag, M; Yang, JC; Stamm, LM; Pang, PS; McHutchison, JG; Dieterich, D; Sulkowski, MS; Wyles, D; Eron, JJ; Lalezari, J; Wang, C; Ruane, PJ; Blick, G; Bhatti, L; Hu, YB; Co, M; Gibbons, K; Trinh, R; Sulkowski, MS; Casado, JL; Bañon, S; Quereda, C; Moreno, A; Elías, MJP; Moreno, S; Saeed, S; Rollet-Kurhajec, K; Strumpf, EC; Klein, MB; Rockstroh, JK; Nelson, M; Katlama, C; Lalezari, J; Mallolas, J; Bloch, M; Matthews, G; Saag, MS; Zamor, P; Orkin, C; Gress, J; Shaughnessy, M; Klopfer, S; Platt, HL; Robertson, M; Sulkowski, M; Lacombe, K; Fontaine, H; Dhiver, C; Rosenthal, E; Metivier, S; Antonini-Michelle, T; Valantin, MA; Miailhes, P; Harent, S; Batisse, D; Pageaux, G-P; Aumaitre, H; Dominguez, S; Chas, J; Allegre, T; Lafeuillade, A; De Truchis, P; De Ledinghen, V; Leroy, V; Billaud, E; Sogni, P; Dabis, F; Wittkop, L; Duvivier, C; Filipovics, A; Fedchuk, L; Bennai, Y; Salmon, D; Karim, QA; Leask, K; Kharsany, A; Humphries, H; Ntombela, F; Samsunder, N; Baxter, C; Frohlich, J; van der Elst, L; Karim, SA; Thirumurthy, H; Masters, S; Rao, S; Murray, K; Omanga, E; Agot, K; Marshall, BDL; Elston, B; Dobrer, S; Montaner, J; Kerr, T; Wood, E; Milloy, M-J; Czaicki, N; Njau, P; Bautista-Arredondo, S; Simba, O; Padian, N; McCoy, S; Haber, N; Tanser, F; Herbst, K; Pillay, D; Bärnighausen, T; Pettifor, A; MacPhail, C; Selin, A; Gomez-Olivé, X; Hughes, J; Wagner, R; Mabuza, W; Mokoena, I; Eshleman, S; Piwowar-Manning, E; Twine, R; Julien, A; Marcus, C; Andrew, P; Wang, J; Xing, Y; McKinstry, L; Hamilton, E; Agyei, Y; Allison, S; Sato, P; Townley, E; Tollman, S; Kahn, K; Solomon, MM; Schechter, M; Liu, AY; McMahan, V; Guanira, JV; Hance, RJ; Chariyalertsak, S; Mayer, KH; Grant, RM; Liu, A; Cohen, S; Vittinghoff, E; Anderson, P; Doblecki-Lewis, S; Bacon, O; Chege, W; Elion, R; Buchbinder, S; Kolber, M; Henderson, F; Taylor, A; Chirwa, L; Williams, T; Borkowf, C; Kasonde, M; Mutanhaurwa, R; Matlhaba, O; Hageman, K; Casillas, P; Hosek, S; Rudy, B; Landovitz, R; Kapogiannis, B; Siberry, G; Liu, N; Rutledge, B; Brothers, J; Rooney, J; Wilson, CM; Hoagland, B; Veloso, VG; De Boni, RB; Madruga, JV; Kallas, EG; Fernandes, NM; Moreira, RI; Liu, AY; Grinsztejn, B; Nair, G; Justman, JE; Piper, J; Marzinke, M; Hendrix, C; Dai, J; Pan, J; Galaska, B; Levy, L; Shwartz, J; McGowan, I; Dezutti, C; Xu, J; Tang, W; Zou, H; Mahapatra, T; Hu, Q; Fu, G; Wang, Z; Lu, L; Zhuang, M; Chen, X; Fu, J; Yu, Y; Lu, J; Jiang, Y; Geng, W; Han, X; Shang, H; Wimonsate, W; Pattanasin, S; Sriporn, A; Luechai, P; Satumay, K; Tippanonth, N; Promda, N; Holtz, T; Chitwarakorn, A; Dunne, E; Chan, G; Bennett, A; Buskin, S; Dombrowski, J; Golden, M; Grosso, A; Stahlman, S; Mothopeng, T; Taruberekera, N; Ouedraogo, G; Ky-Zerbo, O; Pitche, V; Anato, S; Sithole, B; Mabuza, X; Ceesay, N; Diouf, D; Trapence, G; Umar, E; Baral, S; Khosropour, CM; Katz, DA; Dombrowski, JC; Golden, MR; Bavinton, BR; Jin, F; Prestage, G; Zablotska, I; Grinsztejn, B; Phanuphak, N; Friedman, RK; Grulich, AE; Sathane, I; Horth, R; Boothe, M; Baltazar, CS; Young, P; Fisher, H; Teodoro, E; Gouveia, ML; Lane, T; Mcfarland, W; Booth, R; Davis, J; Dvoryak, S; Brewster, J; Strathdee, S; Latkin, C; Joseph, B; Milloy, MJ; Nguyen, HH; Bui, DD; Dinh, TTT; Nguyen, MS; Tran, HT; Le Hai Nguyen; Van Nguyen, TT; Vu, QD; Nhan, T; Le, AKA; Nguyen, BC; Suthar, A; Lo, Y-R; Pham, HT; Le, MG; Nguyen, HL; Kato, M; Richardson, L; Kerr, T; Hogg, B; Guillemi, S; Montaner, J; Wood, E; Milloy, M-J; Cousien, A; Leclerc, P; Morissette, C; Bruneau, J; Roy, É; Yazdanpanah, Y; Cox, J; Bershteyn, A; Klein, D; Oishi, K; Eckhoff, P; Leisegang, R; Mcmahon, J; Hislop, M; Stinson, K; Boulle, A; Elliott, J; Maartens, G; Kim, A; Nganga, L; Mukui, I; Wamicwe, J; Mwanyumba, S; Bowen, N; Wiesner, L; De Cock, K; Han, L; Tang, W; Best, J; Zhang, Y; Kim, J; Liu, F; Mollan, K; Hudgens, M; Bayus, B; Terris-Prestholt, F; Galler, S; Yang, L; Peeling, R; Volberding, P; Ma, B; Yang, B; Huang, S; Fenton, K; Wei, C; Tucker, J; Dombrowski, JC; Hughes, JP; Buskin, SE; Simoni, JM; Katz, D; Fleming, M; Nunez, A; Golden, MR; Schmitz, K; Scheepers, E; Okonji, E; Kawooya, V; Yotebieng, M; Thirumurthy, H; Moracco, KE; Kawende, B; Chalachala, JL; Wenzi, LK; Ravelomanana, NLR; Edmonds, A; Thompson, D; Okitolonda, E; Behets, F; Musarandega, R; Mahomva, A; Robinson, J; Tumbare, E; Sen, PD; Hakobyan, A; Mushavi, A; Domercant, JW; Puttkammer, N; Lu, L; Francois, K; Duncan, D; Grand'Pierre, R; Lowrance, D; Adler, M; Tih, PM; Katayi, E; Mboh, E; Bonje, E; Lem, E; Awa, JC; Lim, JR; Duncan, D; Petit, L; Bianchi, F; Welty, T; Achu, MN; Tayong, G; Tene, G; Mosoko, JJ; Bolu, O; Kieffer, MP; Woelk, G; Mpofu, D; Cathcart, R; Okala, SG; King, DF; Shattock, RJ; Jacob, RA; Moyo, T; Schomaker, M; Abrahams, F; Pujol, BG; Dorfman, J; Valenzuela-Ponce, H; Ávila-Ríos, S; Garrido-Rodríguez, D; García-Téllez, T; Soto-Nava, M; Escamilla-Gómez, T; García-Morales, C; Cortés-Álvarez, J; Hernández-Juan, R; Murakami-Ogasawara, A; Mejía-Villatoro, C; Pascale, J; Porras, G; Quant, C; Lorenzana, I; Meza, R; Palou, E; Manzanero, M; Reyes-Terán, G; Mailiiard, RB; Smith, KN; Piazza, P; Mullins, JI; Rinaldo, CR; Planas, D; Gosselin, A; Monteiro, P; Goulet, J-P; Da Fonseca, S; Cléret-Buhot, A; Jenabian, M-A; Routy, J-P; Ancuta, P; Jensen, K; dela Pena-Ponce, MG; Piatak, M; Jacobs, W; Fennelly, G; Mollan, K; Hudgens, M; Kozlowski, P; Amedee, A; Estes, J; Lifson, J; Van Rompay, K; Larsen, M; De Paris, K; Malatinkova, E; De Spiegelaere, W; Bonczkowski, P; Kiselinova, M; Vervisch, K; Trypsteen, W; Johnson, M; Verhofstede, C; de Looze, D; Murray, C; Loes, SK-D; Vandekerckhove, L; Fletcher, JLK; Pinyakorn, S; de Souza, M; Akapirat, S; Trichavaroj, R; Pankam, T; Kroon, E; Colby, D; Prueksakaew, P; Suttichom, D; Kim, JH; Phanuphak, P; Phanuphak, N; Ananworanich, J; Vandendriessche, A; Mourez, T; Lemée, V; Debab, Y; Peytavin, G; Ladner, J; Caron, F; Plantier, J-C; Leporrier, J; Colby, D; Phanuphak, N; Sirivichayakul, S; Prueksakaew, P; Saengtawan, P; Trichavaroj, R; Crowell, T; Kim, J; Ananworanich, J; Phanuphak, P; Argento, E; Duff, P; Bingham, B; Nguyen, P; Strathdee, S; Shannon, K; Namey, E; Perry, B; Headley, J; Yao, KA; Ouattara, M; Shighata, C; Ferguson, M; Lane, T; Sibanyoni, M; Manyuchi, A; Osmand, T; Marr, A; Grasso, M; Isdahl, Z; Mutanha, N; Makhubela, P; Silima, M; Zuma, N; Struthers, H; McIntyre, J; Rees, H; Venter, F; Lancaster, K; Lungu, T; Hosseinipour, M; Chadwick, K; Dibb, Z; Go, VF; Pence, BW; Powers, KA; Hoffman, IF; Miller, WC; Sedaghat, A; Karamouzian, M; Sharifi, H; Mirzazadeh, A; Shokoohi, M; Haghdoost, A; Schwartz, S; Lambert, A; Phaswana-Mafuya, N; Holland, C; Kose, Z; Mcingana, M; Sweitzer, S; Baral, S; Grimsrud, A; Lesosky, M; Kalombo, C; Bekker, L-G; Myer, L; Caballero, P; Da Silva, CM; Da Cruz, M; Plazy, M; ElFarouki, K; Iwuji, C; Okesola, N; Orne-Gliemann, J; Larmarange, J; Newell, M-L; Pillay, D; Dabis, F; Dray-Spira, R; Rebeiro, PF; Cesar, C; Shepherd, BE; De Boni, RB; Cortés, C; Rodriguez, F; Belaunzarán-Zamudio, P; Pape, JW; Padgett, D; Hoces, D; McGowan, CC; Cahn, P; Pilcher, C; Hatano, H; Dasgupta, A; Jones, D; Torres, S; Calderon, F; Ospina-Norvell, C; Hartogensis, W; Demicco, E; Geng, E; Gandhi, M; Havlir, D; Wagner, A; Njuguna, I; Mugo, C; Inwani, I; Maleche-Obimbo, E; Sherr, K; Wamalwa, D; John-Stewart, G; Slyker, J; Bandason, T; Mchugh, G; Ferrand, R; Munyati, S; Kranzer, K; Chonzi, P; Elyanu, P; Magongo, E; Asire, B; Lukabwe, I; Bitimwine, H; Katureebe, C; Achii, P; Mulema, V; Dziuban, E; Sugandhi, N; Musiime, V; Namuwenge, N; Musinguzi, J; Manno, EC; Bamford, A; Conejo, PR; Marquez, L; Mellado, MJ; Muñoz-Fernández, MÁ; Spoulou, V; Klein, N; Ananworanich, J; Della Negra, M; Ziegler, JB; Meanson, E; Lyall, H; Shingadia, D; Di Biagio, A; Giacomet, V; Vibeke, R; de Sousa Marques, HH; Salo, E; Volokha, A; Scherpbier, HJ; Niehues, T; Levy, J; Marczynska, M; Mardarescu, M; Reliquet, V; Giaquinto, C; Bernardi, S; Palma, P; Ronen, K; Mcgrath, C; Langat, A; Kinuthia, J; Omolo, D; Singa, B; Katana, A; Nganga, L; John-Stewart, G; Krebs, E; Min, JE; Barrios, R; Montaner, J; Nosyk, B; Kelly, S; Shattock, A; Kerr, C; Stuart, R; Papoyan, A; Grigoryan, T; Hovhannisyan, R; Grigoryan, S; Wilson, D; Rajkotia, Y; Zang, O; Nguimkeu, P; Djurovic, I; Estill, J; Ford, N; Salazar-Vizcaya, L; Haas, A; Blaser, N; Egger, M; Habiyambere, V; Keiser, O; Chuma, B; Koseki, S; Musau, S; Johns, B; Gatome-Munyua, A; Honermann, B; Millett, G; Lindsey, K; Wijayaratne, S; Sherwood, J; MacAllister, J; Le, A; Taylor, J; Dong, W; McCloskey, R; Woods, C; Hayashi, K; Milloy, M-J; Harrigan, PR; Poon, AF; Brumme, ZL; Garrido-Rodriguez, D; Avila-Rios, S; Valenzuela-Ponce, H; García-Tellez, T; Quiroz-Morales, V; García-Morales, C; Soto-Nava, M; Murakami-Ogasawara, A; Fernandez-Lopez, JC; Terán, GR; Alcami, J; Bermejo, M; Descours, B; Mateos, E; Lederman, MM; Benkirane, M; Coiras, M; Purcell, D; Jacobson, J; Harty, L; Jarman, K; Lackovic, K; Khoury, G; Mota, T; Lee, M; Bernardi, G; Saleh, S; Sonza, S; Lewin, S; Capoferri, A; Sievers, M; Redd, A; Cash, A; Xu, D; Porcella, SF; Quinn, T; Siliciano, RF; Levis, M; Ambinder, RF; Durand, CM; Lee, S-K; Zhou, S; Archin, N; Margolis, D; Swanstrom, R; Alcaide, M; Chisembele, M; Malupande, E; Arheart, K; Jones, D; Fischl, M; Vicol, LA; Hornsberger, A; Pick, N; Van Schalkwyk, J; Bloomenthal, D; Christilaw, J; Money, D; Pyra, M; Heffron, R; Mugo, NR; Nanda, K; Thomas, KK; Celum, C; Kourtis, AP; Baeten, JM; Ajibola, G; Shapiro, R; Zash, R; Holmes, L; Batlang, O; Ramogothobeng, K; Chilisa, F; Bennett, K; Makhema, J; Lockman, S; Powis, K; Lippman, SA; Pettifor, AP; Neilands, TB; MacPhail, C; Peacock, D; Maman, S; Twine, R; Selin, A; Kahn, K; Derksen, L; Muula, A; van Oosterhout, J; van Lettow, M; Matengeni, A; Sodhi, S; Katz, D; Golden, M; Hughes, J; Farquhar, C; Stekler, J; Lippman, SA; Moran, ME; Ventura, A; Castillo, LS; Buchbinder, S; Treves-Kagan, S; Sevelius, JM; Mavedzenge, SN; Sibanda, E; Mavengere, Y; Hatzold, K; Mugurungi, O; Ncube, G; Cowan, F; Muffih, PT; Mboh, E; Fang, E; Wainfen, W; Fon, H; Welty, T; Shields, R; Golden, M; Bachireddy, C; Izenberg, J; Soule, M; Dvoryak, S; Altice, F; Nosyk, B; Min, JE; Evans, E; Li, L; Liu, L; Lima, V; Wood, E; Montaner, J; Beletsky, L; Gonzalez-Zuniga, P; Rangel, G; Werb, D; Arredondo, J; Strathdee, SA; Lambdin, BH; Nyandindi, C; Bruce, D; Sabuni, N; Magimba, A; Matiko, E; Milloy, M-J; Kerr, T; Hogg, R; Guillemi, S; Montaner, J; Wood, E; Merlini, E; Iannuzzi, F; Bai, F; Trunfio, M; Bonora, S; Calcagno, A; Cannizzo, ES; Basilissi, M; Bini, T; Monforte, AD; Marchetti, G; O'Brien, M; Manches, O; Wilen, C; Wu, V; Sunseri, N; Bhardwaj, N; Bego, MG; Côté, ÉA; Aschman, N; Mercier, J; Weissenhorn, W; Cohen, ÉA; Turrini, F; Kajaste-Rudnitski, A; Marelli, SS; Van Lint, C; Das, AT; Berkout, B; Vicenzi, E; Simpson, S; deSilva, T; Yindom, L-M; Leligdowicz, A; Vincent, T; Rowland-Jones, S; Webb, GM; Chew, GM; Fujita, T; Burwitz, BJ; Wu, HL; Reed, JS; Hammond, KB; Hansen, SG; Maurer, M; Korman, AJ; Ndhlovu, LC; Sacha, JB; Esser, S; Geisel, MHM; Arendt, M; Schulze, C; Holzendorf, V; Warnke, A; Brockmeyer, NH; Hower, M; Schadendorf, D; Neumann, T; Eisele, L; Erbel, R; Moebus, S; Jöckel, K-H; Reinsch, N; Hamzah, L; Tiraboschi, JM; Toby, M; Iveson, H; Mant, C; John, C; Burling, K; Kulasegaram, R; Teague, A; Post, FA; Fox, J; Grant, P; Kitch, D; McComsey, G; Collier, A; Koletar, S; Erlandson, K; Yin, M; Bartali, B; Ha, B; Melbourne, K; Brown, T; Sudjaritruk, T; Bunupuradah, T; Aurpibul, L; Kosalaraksa; Kurniati, N; Puthanakit, T; Spinner, CD; Kern, KE; Noe, S; von Werder, A; Schwerdtfeger, C; Schmid, RM; Zink, A; Wolf, E; Iakoubov, R; Paraskevis, D; Nikolopoulos, G; Sypsa, V; Psichogiou, M; Malliori, M; Friedman, SR; Hatzakis, A; Thompson, LH; Wertheim, JO; Reza, T; Wylie, JL; Emmanuel, F; Brooks, J; Blanchard, JF; Sandstrom, P; Tee, KK; Kantor, R; Sungkanuparph, S; Takebe, Y; Li, P; Ditangco, R; Phanuphak, P; Sirisanthana, T; Sim, B; Ratanasuwan, W; Kantipong, P; Mustafa, M; Merati, TP; Jiamsakul, A; Singtoroj, T; Kamarulzaman, A; Sulaberidze, L; Mirzazadeh, A; Chikovani, I; Shengelia, N; Tsereteli, N; Gotsadze, G; Mulawa, M; Reyes, H; Foshee, V; Halpern, C; Kajula, L; Maman, S; Treves-Kagan, S; Ayadi, AE; Pettifor, A; MacPhail, C; Twine, R; Maman, S; Kahn, K; Lippman, SA; Camlin, CS; Ssemmondo, E; Chamie, G; Kwarisiima, D; Sang, N; Bukusi, EA; Cohen, CR; Kamya, MR; Havlir, D; Schley, A; Skowronska, E; Okonji, E; Scheepers, E; Feldacker, C; Myers, S; Cesar, F; Parades, Z; Ferrao, C; Citao, SC; Mudender, F; Golden, M; Mark, J; Kinuthia, J; Osoti, A; Gone, M; Asila, V; Parikh, S; Krakowiak, D; Betz, B; Richardson, B; Roxby, A; Farquhar, C; Pina, C; Dange, A; Neytra, S; Kambli, H; Karambe, S; Chhabra, R; Patel, V; Ndlovu, B; Hermanus, T; Tumba, N; Moore, P; Jaggernath, M; Walker, BD; Morris, L; Ndung'u, T; Leitman, EM; Hurst, J; Mori, M; Matthews, PC; Frahm, N; Kublin, J; Gray, GE; Goulder, PJ; Demarco, T; Rountree, W; Hora, B; Chen, Y; Keinonen, S; Racz, L; Daniell, L; Louzao, R; Sanchez, A; Busch, M; Denny, T; Gao, F; Johnson, A; Jacob, R; Haeryfar, M; Dikeakos, J; Mohammed, T; Gaseitsiwe, S; Matlhagela, K; Matsheka, M; Moyo, S; Musonda, R; Moukambi, F; Rabezanahary, H; Rodrigues, V; Estaquier, J; Ndjoyi-Mbiguino, A; Nzengui, GFN; Kamdem, HM; Bélec, L; Viana, R; Xaba, T; Stojiljkovic, T; Gunther, N; Wallis, C; Grimsrud, A; Cornell, M; Schomaker, M; Fox, MP; Orrell, C; Prozesky, H; Stinson, K; Tanser, F; Egger, M; Myer, L; Nsumba, MS; Barbara, C; Musomba, RZ; Kaimal, A; Ivan, K; Isaac, L; Laurence, J; Rosalind, P-R; Andrew, K; Khan, A; Hans, L; Gonzales, L; Carmona, S; Hsiao, N-Y; Brophy, J; Lee, T; Sauve, L; Bitnun, A; Singer, J; Kakkar, F; Lapointe, N; Alimenti, A; Money, D; Vaudry, W; Samson, L; Singer, J; Bitnun, A; Lee, T; Samson, L; Brophy, J; Money, D; Alimenti, A; Vaudry, W; Kakkar, F; Lapointe, N; Sauve, L; du Lou, AD; Pannetier, J; Ravalihasy, A; Gosselin, A; Supervie, V; Bajos, N; Lert, F; Lydie, N; Dray-Spira, R; Kerani, R; Herbeck, J; Buskin, S; Dombrowski, J; Bennett, A; Barash, E; Barbee, L; Golden, M; Chang, L; Grabowski, MK; Ssekubugu, R; Nalugoda, F; Reynolds, S; Lessler, J; Moore, S; Quinn, T; Gray, R; Serwadda, D; Wawer, M; Ramachandran, A; Manabe, Y; Rajasingham, R; Shah, M; Schwarz, M; Flick, R; Harawa, M; Simon, K; Kim, M; Robison, J; Ahmed, S; Schramm, B; Tayea, A; Wolters, L; Nicholas, S; Masiku, CW; Zolowere, DB; Mhango, E; Kandulu, JR; Etard, J-F; Amaros, I; Szumilin, E; Gueguen, M; Ndulue, N; Etsetowaghan, A; Gabriel, C; Ibrahim, J; Seclen-Palacin, J; Natumanya, E; Nabitaka, L; Bitarakwate, E; Ismail, S; Moshgabadi, N; Galli, R; Daly, A; Ko, SMS; Zhang, M; Westgard, T; Bulpitt, A; Shackleton, CR 2015 8th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015). Journal Article 2015-01-01T00:00:00Z http://hdl.handle.net/11343/273316 Hanieh, S; Mahanty, S; Gurruwiwi, G; Kearns, T; Dhurrkay, R; Gondarra, V; Shield, J; Ryan, N; Azzato, F; Ballard, SA; Orlando, N; Nicholson, S; Gibney, K; Brimblecombe, J; Page, W; Harrison, LC; Biggs, B-A 2021-01-06 Enteric pathogen infection and consequences for child growth in young Aboriginal Australian children: a cross-sectional study BACKGROUND: To determine the prevalence of enteric infections in Aboriginal children aged 0-2 years using conventional and molecular diagnostic techniques and to explore associations between the presence of pathogens and child growth. METHODS: Cross-sectional analysis of Aboriginal children (n = 62) residing in a remote community in Northern Australia, conducted from July 24th - October 30th 2017. Stool samples were analysed for organisms by microscopy (directly in the field and following fixation and storage in sodium-acetate formalin), and by qualitative PCR for viruses, bacteria and parasites and serology for Strongyloides-specific IgG. Child growth (height and weight) was measured and z scores calculated according to WHO growth standards. RESULTS: Nearly 60% of children had evidence for at least one enteric pathogen in their stool (37/62). The highest burden of infection was with adenovirus/sapovirus (22.9%), followed by astrovirus (9.8%) and Cryptosporidium hominis/parvum (8.2%). Non-pathogenic organisms were detected in 22.5% of children. Ten percent of children had diarrhea at the time of stool collection. Infection with two or more pathogens was negatively associated with height for age z scores (- 1.34, 95% CI - 2.61 to - 0.07), as was carriage of the non-pathogen Blastocystis hominis (- 2.05, 95% CI - 3.55 to - 0.54). CONCLUSIONS: Infants and toddlers living in this remote Northern Australian Aboriginal community had a high burden of enteric pathogens and non-pathogens. The association between carriage of pathogens/non-pathogens with impaired child growth in the critical first 1000 days of life has implications for healthy child growth and development and warrants further investigation. These findings have relevance for many other First Nations Communities that face many of the same challenges with regard to poverty, infections, and malnutrition. Journal Article 2021-01-06T00:00:00Z http://hdl.handle.net/11343/273315 Bateman, RM; Sharpe, MD; Jagger, JE; Ellis, CG; Solé-Violán, J; López-Rodríguez, M; Herrera-Ramos, E; Ruíz-Hernández, J; Borderías, L; Horcajada, J; González-Quevedo, N; Rajas, O; Briones, M; Rodríguez de Castro, F; Rodríguez Gallego, C; Esen, F; Orhun, G; Ergin Ozcan, P; Senturk, E; Ugur Yilmaz, C; Orhan, N; Arican, N; Kaya, M; Kucukerden, M; Giris, M; Akcan, U; Bilgic Gazioglu, S; Tuzun, E; Riff, R; Naamani, O; Douvdevani, A; Takegawa, R; Yoshida, H; Hirose, T; Yamamoto, N; Hagiya, H; Ojima, M; Akeda, Y; Tasaki, O; Tomono, K; Shimazu, T; Ono, S; Kubo, T; Suda, S; Ueno, T; Ikeda, T; Hirose, T; Ogura, H; Takahashi, H; Ojima, M; Kang, J; Nakamura, Y; Kojima, T; Shimazu, T; Ikeda, T; Suda, S; Izutani, Y; Ueno, T; Ono, S; Taniguchi, T; O, M; Dinter, C; Lotz, J; Eilers, B; Wissmann, C; Lott, R; Meili, MM; Schuetz, PS; Hawa, H; Sharshir, M; Aburageila, M; Salahuddin, N; Chantziara, V; Georgiou, S; Tsimogianni, A; Alexandropoulos, P; Vassi, A; Lagiou, F; Valta, M; Micha, G; Chinou, E; Michaloudis, G; Kodaira, A; Ikeda, T; Ono, S; Ueno, T; Suda, S; Izutani, Y; Imaizumi, H; De la Torre-Prados, MV; Garcia-De la Torre, A; Enguix-Armada, A; Puerto-Morlan, A; Perez-Valero, V; Garcia-Alcantara, A; Bolton, N; Dudziak, J; Bonney, S; Tridente, A; Nee, P; Nicolaes, G; Wiewel, M; Schultz, M; Wildhagen, K; Horn, J; Schrijver, R; Van der Poll, T; Reutelingsperger, C; Pillai, S; Davies, G; Mills, G; Aubrey, R; Morris, K; Williams, P; Evans, P; Gayat, EG; Struck, J; Cariou, A; Deye, N; Guidet, B; Jabert, S; Launay, J; Legrand, M; Léone, M; Resche-Rigon, M; Vicaut, E; Vieillard-Baron, A; Mebazaa, A; Arnold, R; Capan, M; Linder, A; Akesson, P; Popescu, M; Tomescu, D; Sprung, CL; Calderon Morales, R; Munteanu, G; Orenbuch-Harroch, E; Levin, P; Kasdan, H; Reiter, A; Volker, T; Himmel, Y; Cohen, Y; Meissonnier, J; Girard, L; Rebeaud, F; Herrmann, I; Delwarde, B; Peronnet, E; Cerrato, E; Venet, F; Lepape, A; Rimmelé, T; Monneret, G; Textoris, J; Beloborodova, N; Moroz, V; Osipov, A; Bedova, A; Sarshor, Y; Pautova, A; Sergeev, A; Chernevskaya, E; Odermatt, J; Bolliger, R; Hersberger, L; Ottiger, M; Christ-Crain, M; Mueller, B; Schuetz, P; Sharma, NK; Tashima, AK; Brunialti, MK; Machado, FR; Assuncao, M; Rigato, O; Salomao, R; Cajander, SC; Rasmussen, G; Tina, E; Söderquist, B; Källman, J; Strålin, K; Lange, AL; Sundén-Cullberg, JS; Magnuson, AM; Hultgren, OH; Davies, G; Pillai, S; Mills, G; Aubrey, R; Morris, K; Williams, P; Evans, P; Pillai, S; Davies, G; Mills, G; Aubrey, R; Morris, K; Williams, P; Evans, P; Pillai, S; Davies, G; Mills, G; Aubrey, R; Morris, K; Williams, P; Evans, P; Van der Geest, P; Mohseni, M; Linssen, J; De Jonge, R; Duran, S; Groeneveld, J; Miller, R; Lopansri, BK; McHugh, LC; Seldon, A; Burke, JP; Johnston, J; Reece-Anthony, R; Bond, A; Molokhia, A; Mcgrath, C; Nsutebu, E; Bank Pedersen, P; Pilsgaard Henriksen, D; Mikkelsen, S; Touborg Lassen, A; Tincu, R; Cobilinschi, C; Tomescu, D; Ghiorghiu, Z; Macovei, R; Wiewel, MA; Harmon, MB; Van Vught, LA; Scicluna, BP; Hoogendijk, AJ; Horn, J; Zwinderman, AH; Cremer, OL; Bonten, MJ; Schultz, MJ; Van der Poll, T; Juffermans, NP; Wiersinga, WJ; Eren, G; Tekdos, Y; Dogan, M; Acicbe, O; Kaya, E; Hergunsel, O; Alsolamy, S; Ghamdi, G; Alswaidan, L; Alharbi, S; Alenezi, F; Arabi, Y; Heaton, J; Boyce, A; Nolan, L; Johnston, J; Dukoff-Gordon, A; Dean, A; Molokhia, A; Mann Ben Yehudah, T; Fleischmann, C; Thomas-Rueddel, D; Haas, C; Dennler, U; Reinhart, K; Suntornlohanakul, O; Khwannimit, B; Breckenridge, F; Puxty, A; Szturz, P; Folwarzcny, P; Svancara, J; Kula, R; Sevcik, P; Caneva, L; Casazza, A; Bellazzi, E; Marra, S; Pagani, L; Vetere, M; Vanzino, R; Ciprandi, D; Preda, R; Boschi, R; Carnevale, L; Lopez, V; Aguilar Arzapalo, M; Barradas, L; Escalante, A; Gongora, J; Cetina, M; Adamik, B; Jakubczyk, D; Kübler, A; Radford, A; Lee, T; Singer, J; Boyd, J; Fineberg, D; Williams, M; Russell, J; Scarlatescu, E; Tomescu, D; Droc, G; Arama, S; Müller, M; Straat, M; Zeerleder, SS; Juffermans, NP; Fuchs, CF; Scheer, CS; Wauschkuhn, SW; Vollmer, MV; Meissner, KM; Kuhn, SK; Hahnenkamp, KH; Rehberg, SR; Gründling, MG; Yamamoto, N; Ojima, M; Hamaguchi, S; Hirose, T; Akeda, Y; Takegawa, R; Tasaki, O; Shimazu, T; Tomono, K; Gómez-Sánchez, E; Heredia-Rodríguez, M; Álvarez-Fuente, E; Lorenzo-López, M; Gómez-Pesquera, E; Aragón-Camino, M; Liu-Zhu, P; Sánchez-López, A; Hernández-Lozano, A; Peláez-Jareño, MT; Tamayo, E; Thomas-Rüddel, DO; Fleischmann, C; Haas, C; Dennler, U; Reinhart, K; Adora, V; Kar, A; Chakraborty, A; Roy, S; Bandyopadhyay, A; Das, M; Mann Ben Yehudah, T; BenYehudah, G; Salim, M; Kumar, N; Arabi, L; Burger, T; Lephart, P; Toth-martin, E; Valencia, C; Hammami, N; Blot, S; Vincent, JL; Lambert, ML; Brunke, J; Riemann, T; Roschke, I; Tincu, R; Cobilinschi, C; Tomescu, D; Ghiorghiu, Z; Macovei, R; Nimitvilai, S; Jintanapramote, K; Jarupongprapa, S; Adukauskiene, D; Valanciene, D; Bose, G; Lostarakos, V; Carr, B; Khedher, S; Maaoui, A; Ezzamouri, A; Salem, M; Chen, J; Cranendonk, DR; Van Vught, LA; Wiewel, MA; Cremer, OL; Horn, J; Bonten, MJ; Schultz, MJ; Van der Poll, T; Wiersinga, WJ; Day, M; Penrice, G; Roy, K; Robertson, P; Godbole, G; Jones, B; Booth, M; Donaldson, L; Kawano, Y; Ishikura, H; Al-Dorzi, H; Almutairi, M; Alhamadi, B; Crizaldo Toledo, A; Khan, R; Al Raiy, B; Arabi, Y; Talaie, H; Van Oers, JA; Harts, A; Nieuwkoop, E; Vos, P; Boussarsar, Y; Boutouta, F; Kamoun, S; Mezghani, I; Koubaji, S; Ben Souissi, A; Riahi, A; Mebazaa, MS; Giamarellos-Bourboulis, E; Tziolos, N; Routsi, C; Katsenos, C; Tsangaris, I; Pneumatikos, I; Vlachogiannis, G; Theodorou, V; Prekates, A; Antypa, E; Koulouras, V; Kapravelos, N; Gogos, C; Antoniadou, E; Mandragos, K; Armaganidis, A; Robles Caballero, AR; Civantos, B; Figueira, JC; López, J; Silva-Pinto, A; Ceia, F; Sarmento, A; Santos, L; Almekhlafi, G; Sakr, Y; Al-Dorzi, H; Khan, R; Baharoon, S; Aldawood, A; Matroud, A; Alchin, J; Al Johani, S; Balkhy, H; Arabi, Y; Alsolamy, S; Yousif, SY; Alotabi, BO; Alsaawi, AS; Ang, J; Curran, MD; Enoch, D; Navapurkar, V; Morris, A; Sharvill, R; Astin, J; Heredia-Rodríguez, M; Gómez-Sánchez, E; Peláez-Jareño, MT; Gómez-Pesquera, E; Lorenzo-López, M; Liu-Zhu, P; Aragón-Camino, M; Hernández-Lozano, A; Sánchez-López, A; Álvarez-Fuente, E; Tamayo, E; Patel, J; Kruger, C; O’Neal, J; Rhodes, H; Jancik, J; François, B; Laterre, PF; Eggimann, P; Torres, A; Sánchez, M; Dequin, PF; Bassi, GL; Chastre, J; Jafri, HS; Ben Romdhane, M; Douira, Z; Kamoun, S; Bousselmi, M; Ben Souissi, A; Boussarsar, Y; Riahi, A; Mebazaa, MS; Vakalos, A; Avramidis, V; Craven, TH; Wojcik, G; Kefala, K; McCoubrey, J; Reilly, J; Paterson, R; Inverarity, D; Laurenson, I; Walsh, TS; Mongodi, S; Bouhemad, B; Orlando, A; Stella, A; Via, G; Iotti, G; Braschi, A; Mojoli, F; Haliloglu, M; Bilgili, B; Kasapoglu, U; Sayan, I; Süzer Aslan, M; Yalcın, A; Cinel, I; Vakalos, A; Avramidis, V; Ellis, HE; Bauchmuller, K; Miller, D; Temple, A; Chastre, J; François, B; Torres, A; Luyt, CE; Sánchez, M; Singer, M; Jafri, HS; Nassar, Y; Ayad, MS; Trifi, A; Abdellatif, S; Daly, F; Nasri, R; Ben Lakhal, S; Bilgili, B; Haliloglu, M; Gul, F; Cinel, I; Kuzovlev, A; Shabanov, A; Polovnikov, S; Moroz, V; Kadrichu, N; Dang, T; Corkery, K; Challoner, P; Bassi, GL; Aguilera, E; Chiurazzi, C; Travierso, C; Motos, A; Fernandez, L; Amaro, R; Senussi, T; Idone, F; Bobi, J; Rigol, M; Torres, A; Hodiamont, CJ; Juffermans, NP; Janssen, JM; Bouman, CS; Mathôt, RA; De Jong, MD; Van Hest, RM; Payne, L; Fraser, GL; Tudor, B; Lahner, M; Roth, G; Krenn, C; Talaie, H; Jault, P; Gabard, J; Leclerc, T; Jennes, S; Que, Y; Rousseau, A; Ravat, F; Al-Dorzi, H; Eissa, A; Al-Harbi, S; Aldabbagh, T; Khan, R; Arabi, Y; Trifi, A; Abdellatif., S; Daly, F; Nasri, R; Ben Lakhal, S; Paramba, F; Purayil, N; Naushad, V; Mohammad, O; Negi, V; Chandra, P; Kleinsasser, A; Witrz, MR; Buchner-Doeven, JF; Tuip-de Boer, AM; Goslings, JC; Juffermans, NP; Van Hezel, M; Straat, M; Boing, A; Van Bruggen, R; Juffermans, N; Markopoulou, D; Venetsanou, K; Kaldis, V; Koutete, D; Chroni, D; Alamanos, I; Koch, L; Jancik, J; Rhodes, H; Walter, E; Maekawa, K; Hayakawa, M; Kushimoto, S; Shiraishi, A; Kato, H; Sasaki, J; Ogura, H; Matauoka, T; Uejima, T; Morimura, N; Ishikura, H; Hagiwara, A; Takeda, M; Tarabrin, O; Shcherbakow, S; Gavrychenko, D; Mazurenko, G; Ivanova, V; Chystikov, O; Plourde, C; Lessard, J; Chauny, J; Daoust, R; Shcherbakow, S; Tarabrin, O; Gavrychenko, D; Mazurenko, G; Chystikov, O; Vakalos, A; Avramidis, V; Kropman, L; In het Panhuis, L; Konings, J; Huskens, D; Schurgers, E; Roest, M; De Laat, B; Lance, M; Durila, M; Lukas, P; Astraverkhava, M; Jonas, J; Budnik, I; Shenkman, B; Hayami, H; Koide, Y; Goto, T; Iqbal, R; Alhamdi, Y; Venugopal, N; Abrams, S; Downey, C; Toh, CH; Welters, ID; Bombay, VB; Chauny, JM; Daoust, RD; Lessard, JL; Marquis, MM; Paquet, JP; Siemens, K; Sangaran, D; Hunt, BJ; Durward, A; Nyman, A; Murdoch, IA; Tibby, SM; Ampatzidou, F; Moisidou, D; Dalampini, E; Nastou, M; Vasilarou, E; Kalaizi, V; Chatzikostenoglou, H; Drossos, G; Spadaro, S; Fogagnolo, A; Fiore, T; Schiavi, A; Fontana, V; Taccone, F; Volta, C; Chochliourou, E; Volakli, E; Violaki, A; Samkinidou, E; Evlavis, G; Panagiotidou, V; Sdougka, M; Mothukuri, R; Battle, C; Guy, K; Mills, G; Evans, P; Wijesuriya, J; Keogh, S; Docherty, A; O’Donnell, R; Brunskill, S; Trivella, M; Doree, C; Holst, L; Parker, M; Gregersen, M; Almeida, J; Walsh, T; Stanworth, S; Moravcova, S; Mansell, J; Rogers, A; Smith, RA; Hamilton-Davies, C; Omar, A; Allam, M; Bilala, O; Kindawi, A; Ewila, H; Ampatzidou, F; Moisidou, D; Nastou, M; Dalampini, E; Malamas, A; Vasilarou, E; Drossos, G; Ferreira, G; Caldas, J; Fukushima, J; Osawa, EA; Arita, E; Camara, L; Zeferino, S; Jardim, J; Gaioto, F; Dallan, L; Jatene, FB; Kalil Filho, R; Galas, F; Hajjar, LA; Mitaka, C; Ohnuma, T; Murayama, T; Kunimoto, F; Nagashima, M; Takei, T; Tomita, M; Omar, A; Mahmoud, K; Hanoura, S; Sudarsanan, S; Sivadasan, P; Othamn, H; Shouman, Y; Singh, R; Al Khulaifi, A; Mandel, I; Mikheev, S; Suhodolo, I; Kiselev, V; Svirko, Y; Podoksenov, Y; Jenkins, SA; Griffin, R; Tovar Doncel, MS; Lima, A; Aldecoa, C; Ince, C; Taha, A; Shafie, A; Mostafa, M; Syed, N; Hon, H; Righetti, F; Colombaroli, E; Castellano, G; Righetti, F; Colombaroli, E; Hravnak, M; Chen, LC; Dubrawski, AD; Clermont, GC; Pinsky, MR; Gonzalez, S; Macias, D; Acosta, J; Jimenez, P; Loza, A; Lesmes, A; Lucena, F; Leon, C; Tovar Doncel, MS; Ince, C; Aldecoa, C; Lima, A; Bastide, M; Richecoeur, J; Frenoy, E; Lemaire, C; Sauneuf, B; Tamion, F; Nseir, S; Du Cheyron, D; Dupont, H; Maizel, J; Shaban, M; Kolko, R; Salahuddin, N; Sharshir, M; AbuRageila, M; AlHussain, A; Mercado, P; Maizel, J; Kontar, L; Titeca, D; Brazier, F; Riviere, A; Joris, M; Soupison, T; De Cagny, B; Slama, M; Wagner, J; Körner, A; Kubik, M; Kluge, S; Reuter, D; Saugel, B; Colombaroli, E; Righetti, F; Castellano, G; Tran, T; De Bels, D; Cudia, A; Strachinaru, M; Ghottignies, P; Devriendt, J; Pierrakos, C; Martínez González, Ó; Blancas, R; Luján, J; Ballesteros, D; Martínez Díaz, C; Núñez, A; Martín Parra, C; López Matamala, B; Alonso Fernández, M; Chana, M; Huber, W; Eckmann, M; Elkmann, F; Gruber, A; Klein, I; Schmid, RM; Lahmer, T; Moller, PW; Sondergaard, S; Jakob, SM; Takala, J; Berger, D; Bastoni, D; Aya, H; Toscani, L; Pigozzi, L; Rhodes, A; Cecconi, M; Ostrowska, C; Aya, H; Abbas, A; Mellinghoff, J; Ryan, C; Dawson, D; Rhodes, A; Cecconi, M; Cronhjort, M; Wall, O; Nyberg, E; Zeng, R; Svensen, C; Mårtensson, J; Joelsson-Alm, E; Aguilar Arzapalo, M; Barradas, L; Lopez, V; Cetina, M; Parenti, N; Palazzi, C; Amidei, LA; Borrelli, FB; Campanale, SC; Tagliazucchi, FT; Sedoni, GS; Lucchesi, DL; Carella, EC; Luciani, AL; Mackovic, M; Maric, N; Bakula, M; Aya, H; Rhodes, A; Grounds, RM; Fletcher, N; Cecconi, M; Avard, B; Zhang, P; Mezidi, M; Charbit, J; Ould-Chikh, M; Deras, P; Maury, C; Martinez, O; Capdevila, X; Hou, P; Linde-Zwirble, WZ; Douglas, ID; Shapiro, NS; Ben Souissi, A; Mezghani, I; Ben Aicha, Y; Kamoun, S; Laribi, B; Jeribi, B; Riahi, A; Mebazaa, MS; Pereira, C; Marinho, R; Antunes, R; Marinho, A; Crivits, M; Raes, M; Decruyenaere, J; Hoste, E; Bagin, V; Rudnov, V; Savitsky, A; Astafyeva, M; Korobko, I; Vein, V; Kampmeier, T; Arnemann, P; Hessler, M; Wald, A; Bockbreder, K; Morelli, A; Van Aken, H; Rehberg, S; Ertmer, C; Arnemann, P; Hessler, M; Kampmeier, T; Rehberg, S; Van Aken, H; Ince, C; Ertmer, C; Reddy, S; Bailey, M; Beasley, R; Bellomo, R; Mackle, D; Psirides, A; Young, P; Reddy, S; Bailey, M; Beasley, R; Bellomo, R; Mackle, D; Young, P; Venkatesh, H; Ramachandran, S; Basu, A; Nair, H; Egan, S; Bates, J; Oliveira, S; Rangel Neto, NR; Reis, FQ; Lee, CP; Lin, XL; Choong, C; Eu, KM; Sim, WY; Tee, KS; Pau, J; Abisheganaden, J; Maas, K; De Geus, H; Lafuente, E; Marinho, R; Moura, J; Antunes, R; Marinho, A; Doris, TE; Monkhouse, D; Shipley, T; Kardasz, S; Gonzalez, I; Stads, S; Groeneveld, AJ; Elsayed, I; Ward, N; Tridente, A; Raithatha, A; Steuber, A; Pelletier, C; Schroeder, S; Michael, E; Slowinski, T; Kindgen-Milles, D; Ghabina, S; Turani, F; Belli, A; Busatti, S; Barettin, G; Candidi, F; Gargano, F; Barchetta, R; Falco, M; Demirkiran, O; Kosuk, M; Bozbay, S; Weber, V; Hartmann, J; Harm, S; Linsberger, I; Eichhorn, T; Valicek, G; Miestinger, G; Hoermann, C; Faenza, S; Ricci, D; Mancini, E; Gemelli, C; Cuoghi, A; Magnani, S; Atti, M; Laddomada, T; Doronzio, A; Balicco, B; Gruda, MC; O’Sullivan, P; Dan, VP; Guliashvili, T; Scheirer, A; Golobish, TD; Capponi, VJ; Chan, PP; Kogelmann, K; Drüner, M; Jarczak, D; Turani, F; Belli, AB; Martni, SM; Cotticelli, VC; Mounajergi, F; Barchetta, R; Morimoto, S; Ishikura, H; Hussain, I; Salahuddin, N; Nadeem, A; Ghorab, K; Maghrabi, K; Kloesel, SK; Goldfuss, C; Stieglitz, A; Stieglitz, AS; Krstevska, L; Albuszies, G; Aguilar Arzapalo, M; Barradas, L; Lopez, V; Escalante, A; Jimmy, G; Cetina, M; Izawa, J; Iwami, T; Uchino, S; Takinami, M; Kitamura, T; Kawamura, T; Powell-Tuck, JG; Crichton, S; Raimundo, M; Camporota, L; Wyncoll, D; Ostermann, M; Hana, A; De Geus, HR; De Geus, HR; Hana, A; Aydogdu, M; Boyaci, N; Yuksel, S; Gursel, G; Cayci Sivri, AB; Meza-Márquez, J; Nava-López, J; Carrillo-Esper, R; Dardashti, A; Grubb, A; Maizel, J; Wetzstein, M; Titeca, D; Kontar, L; Brazier, F; De Cagny, B; Riviere, A; Soupison, T; Joris, M; Slama, M; Peters, E; Njimi, H; Pickkers, P; Vincent, JL; Waraich, M; Doyle, J; Samuels, T; Forni, L; Desai, N; Baumber, R; Gunning, P; Sell, A; Lin, S; Torrence, H; O’Dwyer, M; Kirwan, C; Prowle, J; Kim, T; O’Connor, ME; Hewson, RW; Kirwan, CJ; Pearse, RM; Prowle, J; Hanoura, S; Omar, A; Othamn, H; Sudarsanan, S; Allam, M; Maksoud, M; Singh, R; Al Khulaifi, A; O’Connor, ME; Hewson, RW; Kirwan, CJ; Pearse, RM; Prowle, J; Uzundere, O; Memis, D; Ýnal, M; Gultekin, A; Turan, N; Aydin, MA; Basar, H; Sencan, I; Kapuagasi, A; Ozturk, M; Uzundurukan, Z; Gokmen, D; Ozcan, A; Kaymak, C; Artemenko, VA; Budnyuk, A; Pugh, R; Bhandari, S; Mauri, T; Turrini, C; Langer, T; Taccone, P; Volta, CA; Marenghi, C; Gattinoni, L; Pesenti, A; Sweeney, L; O’Sullivan, A; Kelly, P; Mukeria, E; MacLoughlin, R; Pfeffer, M; Thomas, JT; Bregman, GB; Karp, GK; Kishinevsky, EK; Stavi, DS; Adi, NA; Poropat, T; Knafelj, R; Llopart, E; Batlle, M; De Haro, C; Mesquida, J; Artigas, A; Pavlovic, D; Lewerentz, L; Spassov, A; Schneider, R; De Smet, S; De Raedt, S; Derom, E; Depuydt, P; Oeyen, S; Benoit, D; Decruyenaere, J; Gobatto, A; Besen, B; Tierno, P; Melro, L; Mendes, P; Cadamuro, F; Park, M; Malbouisson, LM; Civantos, BC; Lopez, JL; Robles, A; Figueira, J; Yus, S; Garcia, A; Oglinda, A; Ciobanu, G; Oglinda, C; Schirca, L; Sertinean, T; Lupu, V; Kelly, P; O’Sullivan, A; Sweeney, L; MacLoughlin, R; O’Sullivan, A; Kelly, P; Sweeney, L; Mukeria, E; Wolny, M; MacLoughlin, R; Pagano, A; Numis, F; Visone, G; Saldamarco, L; Russo, T; Porta, G; Paladino, F; Bell, C; Liu, J; Debacker, J; Lee, C; Tamberg, E; Campbell, V; Mehta, S; Silva-Pinto, A; Sarmento, A; Santos, L; Kara, Ý; Yýldýrým, F; Zerman, A; Güllü, Z; Boyacý, N; Basarýk Aydogan, B; Gaygýsýz, Ü; Gönderen, K; Arýk, G; Turkoglu, M; Aydogdu, M; Aygencel, G; Ülger, Z; Gursel, G; Boyacý, N; Isýkdogan, Z; Özdedeoglu, Ö; Güllü, Z; Badoglu, M; Gaygýsýz, U; Aydogdu, M; Gursel, G; Kongpolprom, N; Sittipunt, C; Eden, A; Kokhanovsky, Y; Bursztein – De Myttenaere, S; Pizov, R; Neilans, L; MacIntyre, N; Radosevich, M; Wanta, B; Weber, V; Meyer, T; Smischney, N; Brown, D; Diedrich, D; Fuller, A; McLindon, P; Sim, K; Shoaeir, M; Noeam, K; Mahrous, A; Matsa, R; Ali, A; Dridi, C; Koubaji, S; Kamoun, S; Haddad, F; Ben Souissi, A; Laribi, B; Riahi, A; Mebazaa, MS; Pérez-Calatayud, A; Carrillo-Esper, R; Zepeda-Mendoza, A; Diaz-Carrillo, M; Arch-Tirado, E; Carbognin, S; Pelacani, L; Zannoni, F; Agnoli, A; Gagliardi, G; Cho, R; Adams, A; Lunos, S; Ambur, S; Shapiro, R; Prekker, M; Thijssen, M; Janssen, L; Foudraine, N; Voscopoulos, CJ; Freeman, J; Voscopoulos, CJ; Freeman, J; George, E; Voscopoulos, CJ; Eversole, D; Freeman, J; George, E; Muttini, S; Bigi, R; Villani, G; Patroniti, N; Williams, G; Voscopoulos, CJ; Freeman, J; George, E; Waldmann, A; Böhm, S; Windisch, W; Strassmann, S; Karagiannidis, C; Waldmann, A; Böhm, S; Windisch, W; Strassmann, S; Karagiannidis, C; Karagiannidis, CK; Waldmann, AW; Böhm, SB; Strassmann, S; Windisch, WW; Persson, P; Lundin, S; Stenqvist, O; Porta, G; Numis, F; Serra, CS; Pagano, AP; Masarone, MM; Rinaldi, LR; Amelia, AA; Fascione, MF; Adinolfi, LA; Ruggiero, ER; Asota, F; O’Rourke, K; Ranjan, S; Morgan, P; DeBacker, JW; Tamberg, E; O’Neill, L; Munshi, L; Burry, L; Fan, E; Mehta, S; Poo, S; Mahendran, K; Fowles, J; Gerrard, C; Vuylsteke, A; Loveridge, R; Chaddock, C; Patel, S; Kakar, V; Willars, C; Hurst, T; Park, C; Best, T; Vercueil, A; Auzinger, G; Borgman, A; Proudfoot, AG; Grins, E; Emiley, KE; Schuitema, J; Fitch, SJ; Marco, G; Sturgill, J; Dickinson, MG; Strueber, M; Khaghani, A; Wilton, P; Jovinge, SM; Sampson, C; Harris-Fox, S; Cove, ME; Vu, LH; Sen, A; Federspiel, WJ; Kellum, JA; Mazo Torre, C; Riera, J; Ramirez, S; Borgatta, B; Lagunes, L; Rello, J; Kuzovlev, AK; Moroz, V; Goloubev, A; Polovnikov, S; Nenchuk, S; Karavana, V; Glynos, C; Asimakos, A; Pappas, K; Vrettou, C; Magkou, M; Ischaki, E; Stathopoulos, G; Zakynthinos, S; Spadaro, S; Kozhevnikova, I; Dalla Corte, F; Grasso, S; Casolari, P; Caramori, G; Volta, C; Andrianjafiarinoa, T; Randriamandrato, T; Rajaonera, T; El-Dash, S; Costa, ELV; Tucci, MR; Leleu, F; Kontar, L; De Cagny, B; Brazier, F; Titeca, D; Bacari-Risal, G; Maizel, J; Amato, M; Slama, M; Mercado, P; Maizel, J; Kontar, L; Titeca, D; Brazier, F; Riviere, A; Joris, M; Soupison, T; De Cagny, B; El Dash, S; Slama, M; Remmington; Fischer, A; Squire, S; Boichat, M; Honzawa, H; Yasuda, H; Adati, T; Suzaki, S; Horibe, M; Sasaki, M; Sanui, M; Marinho, R; Daniel, J; Miranda, H; Marinho, A; Milinis, K; Cooper, M; Williams, GR; McCarron, E; Simants, S; Patanwala, I; Welters, I; Su, Y; Fernández Villanueva, J; Fernández Garda, R; López Lago, A; Rodríguez Ruíz, E; Hernández Vaquero, R; Tomé Martínez de Rituerto, S; Varo Pérez, E; Lefel, N; Schaap, F; Bergmans, D; Olde Damink, S; Van de Poll, M; Tizard, K; Lister, C; Poole, L; Ringaitiene, D; Gineityte, D; Vicka, V; Norkiene, I; Sipylaite, J; O’Loughlin, A; Maraj, V; Dowling, J; Velasco, MB; Dalcomune, DM; Dias, EB; Fernandes, SL; Oshima, T; Graf, S; Heidegger, C; Genton, L; Karsegard, V; Dupertuis, Y; Pichard, C; Friedli, N; Stanga, Z; Mueller, B; Schuetz, P; Vandersteen, L; Stessel, B; Evers, S; Van Assche, A; Jamaer, L; Dubois, J; Marinho, R; Castro, H; Moura, J; Valente, J; Martins, P; Casteloes, P; Magalhaes, C; Cabral, S; Santos, M; Oliveira, B; Salgueiro, A; Marinho, A; Marinho, R; Santos, M; Lafuente, E; Castro, H; Cabral, S; Moura, J; Martins, P; Oliveira, B; Salgueiro, A; Duarte, S; Castro, S; Melo, M; Casteloes, P; Marinho, A; Gray, S; Maipang, K; Bhurayanontachai, R; Grädel, LG; Schütz, P; Langlois, P; Manzanares, W; Tincu, R; Cobilinschi, C; Tomescu, D; Ghiorghiu, Z; Macovei, R; Manzanares, W; Langlois, P; Lemieux, M; Elke, G; Bloos, F; Reinhart, K; Heyland, D; Langlois, P; Lemieux, M; Aramendi, I; Heyland, D; Manzanares, W; Su, Y; Marinho, R; Babo, N; Marinho, A; Hoshino, M; Haraguchi, Y; Kajiwara, S; Mitsuhashi, T; Tsubata, T; Aida, M; Rattanapraphat, T; Bhurayanontachai, R; Kongkamol, C; Khwannimit, B; Marinho, R; Santos, M; Castro, H; Lafuente, E; Salgueiro, A; Cabral, S; Martins, P; Moura, J; Oliveira, B; Melo, M; Xavier, B; Valente, J; Magalhaes, C; Casteloes, P; Marinho, A; Moisidou, D; Ampatzidou, F; Koutsogiannidis, C; Moschopoulou, M; Drossos, G; Taskin, G; Çakir, M; Güler, AK; Taskin, A; Öcal, N; Özer, S; Yamanel, L; Wong, JM; Fitton, C; Anwar, S; Stacey, S; Aggou, M; Fyntanidou, B; Patsatzakis, S; Oloktsidou, E; Lolakos, K; Papapostolou, E; Grosomanidis, V; Suda, S; Ikeda, T; Ono, S; Ueno, T; Izutani, Y; Gaudry, S; Desailly, V; Pasquier, P; Brun, PB; Tesnieres, AT; Ricard, JD; Dreyfuss, D; Mignon, A; White, JC; Molokhia, A; Dean, A; Stilwell, A; Friedlaender, G; Peters, M; Stipulante, S; Delfosse, A; Donneau, AF; Ghuysen, A; Feldmann, C; Freitag, D; Dersch, W; Irqsusi, M; Eschbach, D; Steinfeldt, T; Wulf, H; Wiesmann, T; Kongpolprom, N; Cholkraisuwat, J; Beitland, S; Nakstad, E; Stær-Jensen, H; Drægni, T; Andersen, G; Jacobsen, D; Brunborg, C; Waldum-Grevbo, B; Sunde, K; Hoyland, K; Pandit, D; Hayakawa, K; Oloktsidou, E; Kotzampassi, K; Fyntanidou, B; Patsatzakis, S; Loukipoudi, L; Doumaki, E; Grosomanidis, V; Yasuda, H; Admiraal, MM; Van Assen, M; Van Putten, MJ; Tjepkema-Cloostermans, M; Van Rootselaar, AF; Horn, J; Ragusa, F; Marudi, A; Baroni, S; Gaspari, A; Bertellini, E; Taha, A; Abdullah, T; Abdel Monem, S; Alcorn, S; McNeill, S; Russell, S; Eertmans, W; Genbrugge, C; Meex, I; Dens, J; Jans, F; De Deyne, C; Cholkraisuwat, J; Kongpolprom, N; Avard, B; Burns, R; Patarchi, A; Spina, T; Tanaka, H; Otani, N; Ode, S; Ishimatsu, S; Cho, J; Moon, JB; Park, CW; Ohk, TG; Shin, MC; Won, MH; Dakova, S; Ramsheva, Z; Ramshev, K; Cho, J; Moon, JB; Park, CW; Ohk, TG; Shin, MC; Cho, J; Moon, JB; Park, CW; Ohk, TG; Shin, MC; Marudi, A; Baroni, S; Gaspari, A; Bertellini, E; Orhun, G; Senturk, E; Ozcan, PE; Sencer, S; Ulusoy, C; Tuzun, E; Esen, F; Tincu, R; Cobilinschi, C; Tomescu, D; Ghiorghiu, Z; Macovei, R; Van Assen, M; Admiraal, MM; Van Putten, MJ; Tjepkema-Cloostermans, M; Van Rootselaar, AF; Horn, J; Fallenius, M; Skrifvars, MB; Reinikainen, M; Bendel, S; Raj, R; Abu-Habsa, M; Hymers, C; Borowska, A; Sivadhas, H; Sahiba, S; Perkins, S; Rubio, J; Rubio, JA; Sierra, R; English, S; Chasse, M; Turgeon, A; Lauzier, F; Griesdale, D; Garland, A; Fergusson, D; Zarychanski, R; Tinmouth, A; Van Walraven, C; Montroy, K; Ziegler, J; Dupont Chouinard, R; Carignan, R; Dhaliwal, A; Lum, C; Sinclair, J; Pagliarello, G; McIntyre, L; English, S; Chasse, M; Turgeon, A; Lauzier, F; Griesdale, D; Garland, A; Fergusson, D; Zarychanski, R; Tinmouth, A; Van Walraven, C; Montroy, K; Ziegler, J; Dupont Chouinard, R; Carignan, R; Dhaliwal, A; Lum, C; Sinclair, J; Pagliarello, G; McIntyre, L; Groza, T; Moreau, N; Castanares-Zapatero, D; Hantson, P; Carbonara, M; Ortolano, F; Zoerle, T; Magnoni, S; Pifferi, S; Conte, V; Stocchetti, N; Carteron, L; Suys, T; Patet, C; Quintard, H; Oddo, M; Rubio, JA; Rubio, J; Sierra, R; Spatenkova, V; Pokorna, E; Suchomel, P; Ebert, N; Jancik, J; Rhodes, H; Bylinski, T; Hawthorne, C; Shaw, M; Piper, I; Kinsella, J; Kink, AK; Rätsep, IR; Boutin, A; Moore, L; Chasse, M; Zarychanski, R; Lauzier, F; English, S; McIntyre, L; Lacroix, J; Griesdale, D; Lessard-Bonaventure, P; Turgeon, AF; Boutin, A; Moore, L; Green, R; Lessard-Bonaventure, P; Erdogan, M; Butler, M; Lauzier, F; Chasse, M; English, S; McIntyre, L; Zarychanski, R; Lacroix, J; Griesdale, D; Desjardins, P; Fergusson, DA; Turgeon, AF; Goncalves, B; Vidal, B; Valdez, C; Rodrigues, AC; Miguez, L; Moralez, G; Hong, T; Kutz, A; Hausfater, P; Amin, D; Struja, T; Haubitz, S; Huber, A; Mueller, B; Schuetz, P; Brown, T; Collinson, J; Pritchett, C; Slade, T; Le Guen, M; Hellings, S; Ramsaran, R; Alsheikhly, A; Abe, T; Kanapeckaite, L; Abu-Habsa, M; Bahl, R; Russell, MQ; Real, KJ; Abu-Habsa, M; Lyon, RM; Oveland, NP; Penketh, J; Mcdonald, M; Kelly, F; Alfafi, M; Alsolamy, S; Almutairi, W; Alotaibi, B; Van den Berg, AE; Schriel, Y; Dawson, L; Meynaar, IA; Talaie, H; Silva, D; Fernandes, S; Gouveia, J; Santos Silva, J; Foley, J; Kaskovagheorgescu, A; Evoy, D; Cronin, J; Ryan, J; Huck, M; Hoffmann, C; Renner, J; Laitselart, P; Donat, N; Cirodde, A; Schaal, JV; Masson, Y; Nau, A; Leclerc, T; Howarth, O; Davenport, K; Jeanrenaud, P; Raftery, S; MacTavish, P; Devine, H; McPeake, J; Daniel, M; Kinsella, J; Quasim, T; Alrabiee, S; Alrashid, A; Alsolamy, S; Gundogan, O; Bor, C; Akýn Korhan, E; Demirag, K; Uyar, M; Frame, F; Ashton, C; Bergstrom Niska, L; Dilokpattanamongkol, P; Suansanae, T; Suthisisang, C; Morakul, S; Karnjanarachata, C; Tangsujaritvijit, V; Mahmood, S; Al Thani, H; Almenyar, A; Vakalos, A; Avramidis, V; Sharvill, R; Penketh, J; Morton, SE; Chiew, YS; Pretty, C; Chase, JG; Shaw, GM; Knafelj, R; Kordis, P; Patel, S; Grover, V; Kuchyn, I; Bielka, K; Aidoni, Z; Grosomanidis, V; Kotzampassi, K; Stavrou, G; Fyntanidou, B; Patsatzakis, S; Skourtis, C; Lee, SD; Williams, K; Weltes, ID; Berhane, S; Arrowsmith, C; Peters, C; Robert, S; Caldas, J; Panerai, RB; Robinson, TG; Camara, L; Ferreira, G; Borg-Seng-Shu, E; De Lima Oliveira, M; Mian, NC; Santos, L; Nogueira, R; Zeferino, SP; Jacobsen Teixeira, M; Galas, F; Hajjar, LA; Killeen, P; McPhail, M; Bernal, W; Maggs, J; Wendon, J; Hughes, T; Taniguchi, LU; Siqueira, EM; Vieira Jr, JM; Azevedo, LC; Ahmad, AN; Abu-Habsa, M; Bahl, R; Helme, E; Hadfield, S; Loveridge, R; Shak, J; Senver, C; Howard-Griffin, R; Wacharasint, P; Fuengfoo, P; Sukcharoen, N; Rangsin, R; Sbiti-Rohr, D; Schuetz, P; Na, H; Song, S; Lee, S; Jeong, E; Lee, K; Cooper, M; Milinis, K; Williams, G; McCarron, E; Simants, S; Patanwala, I; Welters, ID; Zoumpelouli, E; Volakli, EA; Chrysohoidou, V; Georgiou, S; Charisopoulou, K; Kotzapanagiotou, E; Panagiotidou, V; Manavidou, K; Stathi, Z; Sdougka, M; Salahuddin, N; AlGhamdi, B; Marashly, Q; Zaza, K; Sharshir, M; Khurshid, M; Ali, Z; Malgapo, M; Jamil, M; Shafquat, A; Shoukri, M; Hijazi, M; Abe, T; Uchino, S; Takinami, M; Rangel Neto, NR; Oliveira, S; Reis, FQ; Rocha, FA; Moralez, G; Ebecken, K; Rabello, LS; Lima, MF; Hatum, R; De Marco, FV; Alves, A; Pinto, JE; Godoy, M; Brasil, PE; Bozza, FA; Salluh, JI; Soares, M; Krinsley, J; Kang, G; Perry, J; Hines, H; Wilkinson, KM; Tordoff, C; Sloan, B; Bellamy, MC; Moreira, E; Verga, F; Barbato, M; Burghi, G; Soares, M; Silva, UV; Azevedo, LC; Torelly, AP; Kahn, JM; Angus, DC; Knibel, MF; Brasil, PE; Bozza, FA; Salluh, JI; Velasco, MB; Dalcomune, DM; Marshall, R; Gilpin, T; Tridente, A; Raithatha, A; Mota, D; Loureiro, B; Dias, J; Afonso, O; Coelho, F; Martins, A; Faria, F; Al-Dorzi, H; Al Orainni, H; AlEid, F; Tlaygeh, H; Itani, A; Hejazi, A; Arabi, Y; Gaudry, S; Messika, J; Ricard, JD; Guillo, S; Pasquet, B; Dubief, E; Dreyfuss, D; Tubach, F; Battle, C; James, K; Temblett, P; Davies, L; Battle, C; Lynch, C; Pereira, S; Cavaco, S; Fernandes, J; Moreira, I; Almeida, E; Seabra Pereira, F; Malheiro, M; Cardoso, F; Aragão, I; Cardoso, T; Fister, M; Knafelj, R; Muraray Govind, P; Brahmananda Reddy, N; Pratheema, R; Arul, ED; Devachandran, J; Velasco, MB; Dalcomune, DM; Knafelj, R; Fister, M; Chin-Yee, N; D’Egidio, G; Thavorn, K; Heyland, D; Kyeremanteng, K; Murchison, AG; Swalwell, K; Mandeville, J; Stott, D; Guerreiro, I; Devine, H; MacTavish, P; McPeake, J; Quasim, T; Kinsella, J; Daniel, M; Goossens, C; Marques, MB; Derde, S; Vander Perre, S; Dufour, T; Thiessen, SE; Güiza, F; Janssens, T; Hermans, G; Vanhorebeek, I; De Bock, K; Van den Berghe, G; Langouche, L; Devine, H; MacTavish, P; Quasim, T; Kinsella, J; Daniel, M; McPeake, J; Miles, B; Madden, S; Devine, H; Weiler, M; Marques, P; Rodrigues, C; Boeira, M; Brenner, K; Leães, C; Machado, A; Townsend, R; Andrade, J; MacTavish, P; McPeake, J; Devine, H; Kinsella, J; Daniel, M; Kishore, R; Fenlon, C; Quasim, T; Fiks, T; Ruijter, A; Te Raa, M; Spronk, P; Chiew, YS; Docherty, P; Dickson, J; Moltchanova, E; Scarrot, C; Pretty, C; Shaw, GM; Chase, JG; Hall, T; Ngu, WC; Jack, JM; Morgan, P; Avard, B; Pavli, A; Gee, X; Bor, C; Akin Korhan, E; Demirag, K; Uyar, M; Shirazy, M; Fayed, A; Gupta, S; Kaushal, A; Dewan, S; Varma, A; Ghosh, E; Yang, L; Eshelman, L; Lord, B; Carlson, E; Helme, E; Broderick, R; Hadfield, S; Loveridge, R; Ramos, J; Forte, D; Yang, F; Hou, P; Dudziak, J; Feeney, J; Wilkinson, K; Bauchmuller, K; Shuker, K; Faulds, M; Raithatha, A; Bryden, D; England, L; Bolton, N; Tridente, A; Bauchmuller, K; Shuker, K; Tridente, A; Faulds, M; Matheson, A; Gaynor, J; Bryden, D; Ramos, J; Peroni, B; Daglius-Dias, R; Miranda, L; Cohen, C; Carvalho, C; Velasco, I; Forte, D; Kelly, JM; Neill, A; Rubenfeld, G; Masson, N; Min, A; Boezeman, E; Hofhuis, J; Hovingh, A; De Vries, R; Spronk, P; Cabral-Campello, G; Aragão, I; Cardoso, T; Van Mol, M; Nijkamp, M; Kompanje, E; Ostrowski, P; Omar, A; Kiss, K; Köves, B; Csernus, V; Molnár, Z; Hoydonckx, Y; Vanwing, S; Stessel, B; Van Assche, A; Jamaer, L; Dubois, J; Medo, V; Galvez, R; Miranda, JP; Stone, C; Wigmore, T; Arunan, Y; Wheeler, A; Bauchmuller, K; Bryden, D; Wong, Y; Poi, C; Gu, C; Molmy, P; Van Grunderbeeck, N; Nigeon, O; Lemyze, M; Thevenin, D; Mallat, J; Ramos, J; Correa, M; Carvalho, RT; Forte, D; Fernandez, A; McBride, C; Koonthalloor, E; Walsh, C; Webber, A; Ashe, M; Smith, K; Jeanrenaud, P; Marudi, A; Baroni, S; Ragusa, F; Bertellini, E; Volakli, EA; Chochliourou, E; Dimitriadou, M; Violaki, A; Mantzafleri, P; Samkinidou, E; Vrani, O; Arbouti, A; Varsami, T; Sdougka, M; Bollen, JA; Van Smaalen, TC; De Jongh, WC; Ten Hoopen, MM; Ysebaert, D; Van Heurn, LW; Van Mook, WN; Sim, K; Fuller, A; Roze des Ordons, A; Couillard, P; Doig, C; Van Keer, RV; Deschepper, RD; Francke, AF; Huyghens, LH; Bilsen, JB; Nyamaizi, B; Dalrymple, C; Molokhia, A; Dobru, A; Marrinan, E; Ankuli, A; Molokhia, A; McPeake, J; Struthers, R; Crawford, R; Devine, H; Mactavish, P; Quasim, T; Morelli, P; Degiovanangelo, M; Lemos, F; MArtinez, V; Verga, F; Cabrera, J; Burghi, G; Rutten, A; Van Ieperen, S; De Geer, S; Van Vugt, M; Der Kinderen, E; Giannini, A; Miccinesi, G; Marchesi, T; Prandi, E 2016-04-20 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. Journal Article 2016-04-20T00:00:00Z http://hdl.handle.net/11343/273314 Pastorello, G; Trotta, C; Canfora, E; Chu, H; Christianson, D; Cheah, Y-W; Poindexter, C; Chen, J; Elbashandy, A; Humphrey, M; Isaac, P; Polidori, D; Reichstein, M; Ribeca, A; van Ingen, C; Vuichard, N; Zhang, L; Amiro, B; Ammann, C; Arain, MA; Ardo, J; Arkebauer, T; Arndt, SK; Arriga, N; Aubinet, M; Aurela, M; Baldocchi, D; Barr, A; Beamesderfer, E; Marchesini, LB; Bergeron, O; Beringer, J; Bernhofer, C; Berveiller, D; Billesbach, D; Black, TA; Blanken, PD; Bohrer, G; Boike, J; Bolstad, PV; Bonal, D; Bonnefond, J-M; Bowling, DR; Bracho, R; Brodeur, J; Brummer, C; Buchmann, N; Burban, B; Burns, SP; Buysse, P; Cale, P; Cavagna, M; Cellier, P; Chen, S; Chini, I; Christensen, TR; Cleverly, J; Collalti, A; Consalvo, C; Cook, BD; Cook, D; Coursolle, C; Cremonese, E; Curtis, PS; D'Andrea, E; da Rocha, H; Dai, X; Davis, KJ; De Cinti, B; de Grandcourt, A; De Ligne, A; De Oliveira, RC; Delpierre, N; Desai, AR; Di Bella, CM; di Tommasi, P; Dolman, H; Domingo, F; Dong, G; Dore, S; Duce, P; Dufrene, E; Dunn, A; Dusek, J; Eamus, D; Eichelmann, U; ElKhidir, HAM; Eugster, W; Ewenz, CM; Ewers, B; Famulari, D; Fares, S; Feigenwinter, I; Feitz, A; Fensholt, R; Filippa, G; Fischer, M; Frank, J; Galvagno, M; Gharun, M; Gianelle, D; Gielen, B; Gioli, B; Gitelson, A; Goded, I; Goeckede, M; Goldstein, AH; Gough, CM; Goulden, ML; Graf, A; Griebel, A; Gruening, C; Grunwald, T; Hammerle, A; Han, S; Han, X; Hansen, BU; Hanson, C; Hatakka, J; He, Y; Hehn, M; Heinesch, B; Hinko-Najera, N; Hortnagl, L; Hutley, L; Ibrom, A; Ikawa, H; Jackowicz-Korczynski, M; Janous, D; Jans, W; Jassal, R; Jiang, S; Kato, T; Khomik, M; Klatt, J; Knohl, A; Knox, S; Kobayashi, H; Koerber, G; Kolle, O; Kosugi, Y; Kotani, A; Kowalski, A; Kruijt, B; Kurbatova, J; Kutsch, WL; Kwon, H; Launiainen, S; Laurila, T; Law, B; Leuning, R; Li, Y; Liddell, M; Limousin, J-M; Lion, M; Liska, AJ; Lohila, A; Lopez-Ballesteros, A; Lopez-Blanco, E; Loubet, B; Loustau, D; Lucas-Moffat, A; Luers, J; Ma, S; Macfarlane, C; Magliulo, V; Maier, R; Mammarella, I; Manca, G; Marcolla, B; Margolis, HA; Marras, S; Massman, W; Mastepanov, M; Matamala, R; Matthes, JH; Mazzenga, F; McCaughey, H; McHugh, I; McMillan, AMS; Merbold, L; Meyer, W; Meyers, T; Miller, SD; Minerbi, S; Moderow, U; Monson, RK; Montagnani, L; Moore, CE; Moors, E; Moreaux, V; Moureaux, C; Munger, JW; Nakai, T; Neirynck, J; Nesic, Z; Nicolini, G; Noormets, A; Northwood, M; Nosetto, M; Nouvellon, Y; Novick, K; Oechel, W; Olesen, JE; Ourcival, J-M; Papuga, SA; Parmentier, F-J; Paul-Limoges, E; Pavelka, M; Peichl, M; Pendall, E; Phillips, RP; Pilegaard, K; Pirk, N; Posse, G; Powell, T; Prasse, H; Prober, SM; Rambal, S; Rannik, U; Raz-Yaseef, N; Rebmann, C; Reed, D; de Dios, VR; Restrepo-Coupe, N; Reverter, BR; Roland, M; Sabbatini, S; Sachs, T; Saleska, SR; Sanchez-Canete, EP; Sanchez-Mejia, ZM; Schmid, HP; Schmidt, M; Schneider, K; Schrader, F; Schroder, I; Scott, RL; Sedlak, P; Serrano-Ortiz, P; Shao, C; Shi, P; Shironya, I; Siebicke, L; Sigut, L; Silberstein, R; Sirca, C; Spano, D; Steinbrecher, R; Stevens, RM; Sturtevant, C; Suyker, A; Tagesson, T; Takanashi, S; Tang, Y; Tapper, N; Thom, J; Tomassucci, M; Tuovinen, J-P; Urbanski, S; Valentini, R; van der Molen, M; van Gorsel, E; van Huissteden, K; Varlagin, A; Verfaillie, J; Vesala, T; Vincke, C; Vitale, D; Vygodskaya, N; Walker, JP; Walter-Shea, E; Wang, H; Weber, R; Westermann, S; Wille, C; Wofsy, S; Wohlfahrt, G; Wolf, S; Woodgate, W; Li, Y; Zampedri, R; Zhang, J; Zhou, G; Zona, D; Agarwal, D; Biraud, S; Torn, M; Papale, D 2021-02-25 The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data (vol 7, 225, 2020) <jats:p>A Correction to this paper has been published: https://doi.org/10.1038/s41597-021-00851-9.</jats:p> Journal Article 2021-02-25T00:00:00Z http://hdl.handle.net/11343/273313 Coignard, J; Lush, M; Beesley, J; O'Mara, TA; Dennis, J; Tyrer, JP; Barnes, DR; McGuffog, L; Leslie, G; Bolla, MK; Adank, MA; Agata, S; Ahearn, T; Aittomaeki, K; Andrulis, IL; Anton-Culver, H; Arndt, V; Arnold, N; Aronson, KJ; Arun, BK; Augustinsson, A; Azzollini, J; Barrowdale, D; Baynes, C; Becher, H; Bermisheva, M; Bernstein, L; Bialkowska, K; Blomqvist, C; Bojesen, SE; Bonanni, B; Borg, A; Brauch, H; Brenner, H; Burwinkel, B; Buys, SS; Caldes, T; Caligo, MA; Campa, D; Carter, BD; Castelao, JE; Chang-Claude, J; Chanock, SJ; Chung, WK; Claes, KBM; Clarke, CL; Collee, JM; Conroy, DM; Czene, K; Daly, MB; Devilee, P; Diez, O; Ding, YC; Domchek, SM; Dork, T; dos-Santos-Silva, I; Dunning, AM; Dwek, M; Eccles, DM; Eliassen, AH; Engel, C; Eriksson, M; Evans, DG; Fasching, PA; Flyger, H; Fostira, F; Friedman, E; Fritschi, L; Frost, D; Gago-Dominguez, M; Gapstur, SM; Garber, J; Garcia-Barberan, V; Garcia-Closas, M; Garcia-Saenz, JA; Gaudet, MM; Gayther, SA; Gehrig, A; Georgoulias, V; Giles, GG; Godwin, AK; Goldberg, MS; Goldgar, DE; Gonzalez-Neira, A; Greene, MH; Guenel, P; Haeberle, L; Hahnen, E; Haiman, CA; Hakansson, N; Hall, P; Hamann, U; Harrington, PA; Hart, SN; He, W; Hogervorst, FBL; Hollestelle, A; Hopper, JL; Horcasitas, DJ; Hulick, PJ; Hunter, DJ; Imyanitov, EN; Jager, A; Jakubowska, A; James, PA; Jensen, UB; John, EM; Jones, ME; Kaaks, R; Kapoor, PM; Karlan, BY; Keeman, R; Khusnutdinova, E; Kiiski, JI; Ko, Y-D; Kosma, V-M; Kraft, P; Kurian, AW; Laitman, Y; Lambrechts, D; Le Marchand, L; Lester, J; Lesueur, F; Lindstrom, T; Lopez-Fernandez, A; Loud, JT; Luccarini, C; Mannermaa, A; Manoukian, S; Margolin, S; Martens, JWM; Mebirouk, N; Meindl, A; Miller, A; Milne, RL; Montagna, M; Nathanson, KL; Neuhausen, SL; Nevanlinna, H; Nielsen, FC; O'Brien, KM; Olopade, OI; Olson, JE; Olsson, H; Osorio, A; Ottini, L; Park-Simon, T-W; Parsons, MT; Pedersen, IS; Peshkin, B; Peterlongo, P; Peto, J; Pharoah, PDP; Phillips, K-A; Polley, EC; Poppe, B; Presneau, N; Angel Pujana, M; Punie, K; Radice, P; Rantala, J; Rashid, MU; Rennert, G; Rennert, HS; Robson, M; Romero, A; Rossing, M; Saloustros, E; Sandler, DP; Santella, R; Scheuner, MT; Schmidt, MK; Schmidt, G; Scott, C; Sharma, P; Soucy, P; Southey, MC; Spinelli, JJ; Steinsnyder, Z; Stone, J; Stoppa-Lyonnet, D; Swerdlow, A; Tamimi, RM; Tapper, WJ; Taylor, JA; Terry, MB; Teule, A; Thull, DL; Tischkowitz, M; Toland, AE; Torres, D; Trainer, AH; Truong, T; Tung, N; Vachon, CM; Vega, A; Vijai, J; Wang, Q; Wappenschmidt, B; Weinberg, CR; Weitzel, JN; Wendt, C; Wolk, A; Yadav, S; Yang, XR; Yannoukakos, D; Zheng, W; Ziogas, A; Zorn, KK; Park, SK; Thomassen, M; Offit, K; Schmutzler, RK; Couch, FJ; Simard, J; Chenevix-Trench, G; Easton, DF; Andrieu, N; Antoniou, AC 2021-02-17 A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10-8, at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD, SP11 and EIF1, genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers. Journal Article 2021-02-17T00:00:00Z http://hdl.handle.net/11343/273312 Shield, J; Braat, S; Watts, M; Robertson, G; Beaman, M; McLeod, J; Baird, RW; Hart, J; Robson, J; Lee, R; McKessar, S; Nicholson, S; Mayer-Coverdale, J; Biggs, B-A 2021-03-01 Seropositivity and geographical distribution of Strongyloides stercoralis in Australia: A study of pathology laboratory data from 2012-2016 BACKGROUND: There are no national prevalence studies of Strongyloides stercoralis infection in Australia, although it is known to be endemic in northern Australia and is reported in high risk groups such as immigrants and returned travellers. We aimed to determine the seropositivity (number positive per 100,000 of population and percent positive of those tested) and geographical distribution of S. stercoralis by using data from pathology laboratories. METHODOLOGY: We contacted all seven Australian laboratories that undertake Strongyloides serological (ELISA antibody) testing to request de-identified data from 2012-2016 inclusive. Six responded. One provided positive data only. The number of people positive, number negative and number tested per 100,000 of population (Australian Bureau of Statistics data) were calculated including for each state/territory, each Australian Bureau of Statistics Statistical Area Level 3 (region), and each suburb/town/community/locality. The data was summarized and expressed as maps of Australia and Greater Capital Cities. PRINCIPAL FINDINGS: We obtained data for 81,777 people who underwent serological testing for Strongyloides infection, 631 of whom were from a laboratory that provided positive data only. Overall, 32 (95% CI: 31, 33) people per 100,000 of population were seropositive, ranging between 23/100,000 (95% CI: 19, 29) (Tasmania) and 489/100,000 population (95%CI: 462, 517) (Northern Territory). Positive cases were detected across all states and territories, with the highest (260-996/100,000 and 17-40% of those tested) in regions across northern Australia, north-east New South Wales and north-west South Australia. Some regions in Greater Capital Cities also had a high seropositivity (112-188/100,000 and 17-20% of those tested). Relatively more males than females tested positive. Relatively more adults than children tested positive. Children were under-represented in the data. CONCLUSIONS/SIGNIFICANCE: The study confirms that substantial numbers of S. stercoralis infections occur in Australia and provides data to inform public health planning. Journal Article 2021-03-01T00:00:00Z http://hdl.handle.net/11343/273311 Burrell, AJC; Serpa Neto, A; Trapani, T; Broadley, T; French, C; Udy, AA; SPRINT-SARI Australia Investigators 2021-02-01 Rapid Translation of COVID-19 Preprint Data into Critical Care Practice. Journal Article 2021-02-01T00:00:00Z http://hdl.handle.net/11343/273310 Lakis, V; Lawlor, RT; Newell, F; Patch, A-M; Mafficini, A; Sadanandam, A; Koufariotis, LT; Johnston, RL; Leonard, C; Wood, S; Rusev, B; Corbo, V; Luchini, C; Cingarlini, S; Landoni, L; Salvia, R; Milella, M; Chang, D; Bailey, P; Jamieson, NB; Duthie, F; Gingras, M-C; Muzny, DM; Wheeler, DA; Gibbs, RA; Milione, M; Pederzoli, P; Samra, JS; Gill, AJ; Johns, AL; Pearson, J; Biankin, A; Grimmond, SM; Waddell, N; Nones, K; Scarpa, A 2021-02-03 DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association Here we report the DNA methylation profile of 84 sporadic pancreatic neuroendocrine tumors (PanNETs) with associated clinical and genomic information. We identified three subgroups of PanNETs, termed T1, T2 and T3, with distinct patterns of methylation. The T1 subgroup was enriched for functional tumors and ATRX, DAXX and MEN1 wild-type genotypes. The T2 subgroup contained tumors with mutations in ATRX, DAXX and MEN1 and recurrent patterns of chromosomal losses in half of the genome with no association between regions with recurrent loss and methylation levels. T2 tumors were larger and had lower methylation in the MGMT gene body, which showed positive correlation with gene expression. The T3 subgroup harboured mutations in MEN1 with recurrent loss of chromosome 11, was enriched for grade G1 tumors and showed histological parameters associated with better prognosis. Our results suggest a role for methylation in both driving tumorigenesis and potentially stratifying prognosis in PanNETs. Journal Article 2021-02-03T00:00:00Z http://hdl.handle.net/11343/273309 Zhang-James, Y; Helminen, EC; Liu, J; ENIGMA-ADHD Working Group; Franke, B; Hoogman, M; Faraone, SV 2021-02-01 Evidence for similar structural brain anomalies in youth and adult attention-deficit/hyperactivity disorder: a machine learning analysis. Attention-deficit/hyperactivity disorder (ADHD) affects 5% of children world-wide. Of these, two-thirds continue to have impairing symptoms of ADHD into adulthood. Although a large literature implicates structural brain differences of the disorder, it is not clear if adults with ADHD have similar neuroanatomical differences as those seen in children with recent reports from the large ENIGMA-ADHD consortium finding structural differences for children but not for adults. This paper uses deep learning neural network classification models to determine if there are neuroanatomical changes in the brains of children with ADHD that are also observed for adult ADHD, and vice versa. We found that structural MRI data can significantly separate ADHD from control participants for both children and adults. Consistent with the prior reports from ENIGMA-ADHD, prediction performance and effect sizes were better for the child than the adult samples. The model trained on adult samples significantly predicted ADHD in the child sample, suggesting that our model learned anatomical features that are common to ADHD in childhood and adulthood. These results support the continuity of ADHD's brain differences from childhood to adulthood. In addition, our work demonstrates a novel use of neural network classification models to test hypotheses about developmental continuity. Journal Article 2021-02-01T00:00:00Z http://hdl.handle.net/11343/273308 Graetz, N; Woyczynski, L; Wilson, KF; Hall, JB; Abate, KH; Abd-Allah, F; Adebayo, OM; Adekanmbi, V; Afshari, M; Ajumobi, O; Akinyemiju, T; Alahdab, F; Al-Aly, Z; Alcalde Rabanal, JE; Alijanzadeh, M; Alipour, V; Altirkawi, K; Amiresmaili, M; Anber, NH; Andrei, CL; Anjomshoa, M; Antonio, CAT; Arabloo, J; Aremu, O; Aryal, KK; Asadi-Aliabadi, M; Atique, S; Ausloos, M; Awasthi, A; Ayala Quintanilla, BP; Azari, S; Badawi, A; Banoub, JAM; Barker-Collo, SL; Barnett, A; Bedi, N; Bennett, DA; Bhattacharjee, NV; Bhattacharyya, K; Bhattarai, S; Bhutta, ZA; Bijani, A; Bikbov, B; Britton, G; Burstein, R; Butt, ZA; Cardenas, R; Carvalho, F; Castaneda-Orjuela, CA; Castro, F; Cerin, E; Chang, J-C; Collison, ML; Cooper, C; Cork, MA; Daoud, F; Das Gupta, R; Weaver, ND; De Neve, J-W; Deribe, K; Desalegn, BB; Deshpande, A; Desta, M; Dhimal, M; Diaz, D; Dinberu, MT; Djalalinia, S; Dubey, M; Dubljanin, E; Duraes, AR; Dwyer-Lindgren, L; Earl, L; Kalan, ME; El-Khatib, Z; Eshrati, B; Faramarzi, M; Fareed, M; Faro, A; Fereshtehnejad, S-M; Fernandes, E; Filip, I; Fischer, F; Fukumoto, T; Garcia, JA; Gill, PS; Gill, TK; Gona, PN; Gopalani, SV; Grada, A; Guo, Y; Gupta, R; Gupta, V; Haj-Mirzaian, A; Haj-Mirzaian, A; Hamadeh, RR; Hamidi, S; Hasan, M; Hassen, HY; Hendrie, D; Henok, A; Henry, NJ; Hernandez Prado, B; Herteliu, C; Hole, MK; Hossain, N; Hosseinzadeh, M; Hu, G; Ilesanmi, OS; Irvani, SSN; Islam, SMS; Izadi, N; Jakovljevic, M; Jha, RP; Ji, JS; Jonas, JB; Shushtari, ZJ; Jozwiak, JJ; Kanchan, T; Kasaeian, A; Karyani, AK; Keiyoro, PN; Kesavachandran, CN; Khader, YS; Khafaie, MA; Khan, EA; Khater, MM; Kiadaliri, AA; Kiirithio, DN; Kim, YJ; Kimokoti, RW; Kinyoki, DK; Kisa, A; Kosen, S; Koyanagi, A; Krishan, K; Defo, BK; Kumar, M; Kumar, P; Lami, FH; Lee, PH; Levine, AJ; Li, S; Liao, Y; Lim, L-L; Listl, S; Lopez, JCF; Majdan, M; Majdzadeh, R; Majeed, A; Malekzadeh, R; Mansournia, MA; Martins-Melo, FR; Masaka, A; Massenburg, BB; Mayala, BK; Mehta, KM; Mendoza, W; Mensah, GA; Meretoja, TJ; Mestrovic, T; Miller, TR; Mini, GK; Mirrakhimov, EM; Moazen, B; Mohammad, DK; Darwesh, AM; Mohammed, S; Mohebi, F; Mokdad, AH; Monasta, L; Moodley, Y; Moosazadeh, M; Moradi, G; Moradi-Lakeh, M; Moraga, P; Morawska, L; Morrison, SD; Mosser, JF; Mousavi, SM; Murray, CJL; Mustafa, G; Nahvijou, A; Najafi, F; Nangia, V; Ndwandwe, DE; Negoi, I; Negoi, RI; Ngunjiri, JW; Cuong, TN; Long, HN; Ningrum, DNA; Noubiap, JJ; Shiadeh, MN; Nyasulu, PS; Oancea, B; Ogbo, FA; Olagunju, AT; Olusanya, BO; Olusanya, JO; Onwujekwe, OE; Ortega-Altamirano, DDV; Ortiz-Panozo, E; Overland, S; Mahesh, PA; Pana, A; Panda-Jonas, S; Pati, S; Patton, GC; Perico, N; Pigott, DM; Pirsaheb, M; Postma, MJ; Pourshams, A; Prakash, S; Puri, P; Qorbani, M; Radfar, A; Rahim, F; Rahimi-Movaghar, V; Rahman, MHU; Rajati, F; Ranabhat, CL; Rawaf, DL; Rawaf, S; Reiner, RC; Remuzzi, G; Renzaho, AMN; Rezaei, S; Rezapour, A; Rios-Gonzalez, C; Roever, L; Ronfani, L; Roshandel, G; Rostami, A; Rubagotti, E; Sadat, N; Sadeghi, E; Safari, Y; Sagar, R; Salam, N; Salamati, P; Salimi, Y; Salimzadeh, H; Samy, AM; Sanabria, J; Milicevic, MMS; Sartorius, B; Sathian, B; Sawant, AR; Schaeffer, LE; Schipp, MF; Schwebel, DC; Senbeta, AM; Sepanlou, SG; Shaikh, MA; Shams-Beyranvand, M; Shamsizadeh, M; Sharafi, K; Sharma, R; She, J; Sheikh, A; Shigematsu, M; Siabani, S; Silveira, DGA; Singh, JA; Sinha, DN; Skirbekk, V; Sligar, A; Sobaih, BH; Soofi, M; Soriano, JB; Soyiri, IN; Sreeramareddy, CT; Sudaryanto, A; Sufiyan, MB; Sutradhar, I; Sylaja, P; Tabares-Seisdedos, R; Tadesse, BT; Temsah, M-H; Terkawi, AS; Tessema, B; Tessema, ZT; Thankappan, KR; Topor-Madry, R; Tovani-Palone, MR; Tran, BX; Car, LT; Ullah, I; Uthman, OA; Valdez, PR; Veisani, Y; Violante, FS; Vlassov, V; Vollmer, S; Vu, GT; Waheed, Y; Wang, Y-P; Wilkinson, JC; Winkler, AS; Wolfe, CDA; Yamada, T; Yeshaneh, A; Yip, P; Yisma, E; Yonemoto, N; Younis, MZ; Yousefifard, M; Yu, C; Bin Zaman, S; Zhang, J; Zhang, Y; Zodpey, S; Gakidou, E; Hay, SI 2021-01-08 Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems BACKGROUND: Human immunodeficiency virus (HIV) remains a public health priority in Latin America. While the burden of HIV is historically concentrated in urban areas and high-risk groups, subnational estimates that cover multiple countries and years are missing. This paucity is partially due to incomplete vital registration (VR) systems and statistical challenges related to estimating mortality rates in areas with low numbers of HIV deaths. In this analysis, we address this gap and provide novel estimates of the HIV mortality rate and the number of HIV deaths by age group, sex, and municipality in Brazil, Colombia, Costa Rica, Ecuador, Guatemala, and Mexico. METHODS: We performed an ecological study using VR data ranging from 2000 to 2017, dependent on individual country data availability. We modeled HIV mortality using a Bayesian spatially explicit mixed-effects regression model that incorporates prior information on VR completeness. We calibrated our results to the Global Burden of Disease Study 2017. RESULTS: All countries displayed over a 40-fold difference in HIV mortality between municipalities with the highest and lowest age-standardized HIV mortality rate in the last year of study for men, and over a 20-fold difference for women. Despite decreases in national HIV mortality in all countries-apart from Ecuador-across the period of study, we found broad variation in relative changes in HIV mortality at the municipality level and increasing relative inequality over time in all countries. In all six countries included in this analysis, 50% or more HIV deaths were concentrated in fewer than 10% of municipalities in the latest year of study. In addition, national age patterns reflected shifts in mortality to older age groups-the median age group among decedents ranged from 30 to 45 years of age at the municipality level in Brazil, Colombia, and Mexico in 2017. CONCLUSIONS: Our subnational estimates of HIV mortality revealed significant spatial variation and diverging local trends in HIV mortality over time and by age. This analysis provides a framework for incorporating data and uncertainty from incomplete VR systems and can help guide more geographically precise public health intervention to support HIV-related care and reduce HIV-related deaths. Journal Article 2021-01-08T00:00:00Z http://hdl.handle.net/11343/273307 Mikropoulos, C; Hutten Selkirk, CG; Saya, S; Bancroft, E; Vertosick, E; Dadaev, T; Brendler, C; Page, E; Dias, A; Evans, DG; Rothwell, J; Maehle, L; Axcrona, K; Richardson, K; Eccles, D; Jensen, T; Osther, PJ; van Asperen, CJ; Vasen, H; Kiemeney, LA; Ringelberg, J; Cybulski, C; Wokolorczyk, D; Hart, R; Glover, W; Lam, J; Taylor, L; Salinas, M; Feliubadaló, L; Oldenburg, R; Cremers, R; Verhaegh, G; van Zelst-Stams, WA; Oosterwijk, JC; Cook, J; Rosario, DJ; Buys, SS; Conner, T; Domchek, S; Powers, J; Ausems, MGEM; Teixeira, MR; Maia, S; Izatt, L; Schmutzler, R; Rhiem, K; Foulkes, WD; Boshari, T; Davidson, R; Ruijs, M; Helderman-van den Enden, ATJM; Andrews, L; Walker, L; Snape, K; Henderson, A; Jobson, I; Lindeman, GJ; Liljegren, A; Harris, M; Adank, MA; Kirk, J; Taylor, A; Susman, R; Chen-Shtoyerman, R; Pachter, N; Spigelman, A; Side, L; Zgajnar, J; Mora, J; Brewer, C; Gadea, N; Brady, AF; Gallagher, D; van Os, T; Donaldson, A; Stefansdottir, V; Barwell, J; James, PA; Murphy, D; Friedman, E; Nicolai, N; Greenhalgh, L; Obeid, E; Murthy, V; Copakova, L; McGrath, J; Teo, S-H; Strom, S; Kast, K; Leongamornlert, DA; Chamberlain, A; Pope, J; Newlin, AC; Aaronson, N; Ardern-Jones, A; Bangma, C; Castro, E; Dearnaley, D; Eyfjord, J; Falconer, A; Foster, CS; Gronberg, H; Hamdy, FC; Johannsson, O; Khoo, V; Lubinski, J; Grindedal, EM; McKinley, J; Shackleton, K; Mitra, AV; Moynihan, C; Rennert, G; Suri, M; Tricker, K; IMPACT study collaborators; Moss, S; Kote-Jarai, Z; Vickers, A; Lilja, H; Helfand, BT; Eeles, RA 2018-03-20 Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition. This corrects the article DOI: 10.1038/bjc.2017.429. Journal Article 2018-03-20T00:00:00Z http://hdl.handle.net/11343/273306 Sargurupremraj, M; Suzuki, H; Jian, X; Sarnowski, C; Evans, TE; Bis, JC; Eiriksdottir, G; Sakaue, S; Terzikhan, N; Habes, M; Zhao, W; Armstrong, NJ; Hofer, E; Yanek, LR; Hagenaars, SP; Kumar, RB; van den Akker, EB; McWhirter, RE; Trompet, S; Mishra, A; Saba, Y; Satizabal, CL; Beaudet, G; Petit, L; Tsuchida, A; Zago, L; Schilling, S; Sigurdsson, S; Gottesman, RF; Lewis, CE; Aggarwal, NT; Lopez, OL; Smith, JA; Hernandez, MCV; van der Grond, J; Wright, MJ; Knol, MJ; Dorr, M; Thomson, RJ; Bordes, C; Le Grand, Q; Duperron, M-G; Smith, A; Knopman, DS; Schreiner, PJ; Evans, DA; Rotter, J; Beiser, AS; Maniega, SM; Beekman, M; Trollor, J; Stott, DJ; Vernooij, MW; Wittfeld, K; Niessen, WJ; Soumare, A; Boerwinkle, E; Sidney, S; Turner, ST; Davies, G; Thalamuthu, A; Volker, U; van Buchem, MA; Bryan, RN; Dupuis, J; Bastin, ME; Ames, D; Teumer, A; Amouyel, P; Kwok, JB; Bulow, R; Deary, IJ; Schofield, PR; Brodaty, H; Jiang, J; Tabara, Y; Setoh, K; Miyamoto, S; Yoshida, K; Nagata, M; Kamatani, Y; Matsuda, F; Psaty, BM; Bennett, DA; De Jager, PL; Mosley, TH; Sachdev, PS; Schmidt, R; Warren, HR; Evangelou, E; Tregouet, D-A; Ikram, MA; Wen, W; DeCarli, C; Srikanth, VK; Jukema, JW; Slagboom, EP; Kardia, SLR; Okada, Y; Mazoyer, B; Wardlaw, JM; Nyquist, PA; Mather, KA; Grabe, HJ; Schmidt, H; Van Duijn, CM; Gudnason, V; Longstreth, WT; Launer, LJ; Lathrop, M; Seshadri, S; Tzourio, C; Adams, HH; Matthews, PM; Fornage, M; Debette, S 2020-12-08 Cerebral small vessel disease genomics and its implications across the lifespan White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WMH-volume in a cohort of 50,970 older individuals, accounting for modification/confounding by hypertension. Aggregated WMH risk variants were associated with altered white matter integrity (p = 2.5×10-7) in brain images from 1,738 young healthy adults, providing insight into the lifetime impact of SVD genetic risk. Mendelian randomization suggested causal association of increasing WMH-volume with stroke, Alzheimer-type dementia, and of increasing blood pressure (BP) with larger WMH-volume, notably also in persons without clinical hypertension. Transcriptome-wide colocalization analyses showed association of WMH-volume with expression of 39 genes, of which four encode known drug targets. Finally, we provide insight into BP-independent biological pathways underlying SVD and suggest potential for genetic stratification of high-risk individuals and for genetically-informed prioritization of drug targets for prevention trials. Journal Article 2020-12-08T00:00:00Z http://hdl.handle.net/11343/273305 Stanaway, JD; Afshin, A; Gakidou, E; Lim, SS; Abate, D; Abate, KH; Abbafati, C; Abbasi, N; Abbastabar, H; Abd-Allah, F; Abdela, J; Abdelalim, A; Abdollahpour, I; Abdulkader, RS; Abebe, M; Abebe, Z; Abera, SF; Abil, OZ; Abraha, HN; Abrham, AR; Abu-Raddad, LJ; Abu-Rmeileh, NME; Accrombessi, MMK; Acharya, D; Acharya, P; Adamu, AA; Adane, AA; Adebayo, OM; Adedoyin, RA; Adekanmbi, V; Ademi, Z; Adetokunboh, OO; Adib, MG; Admasie, A; Adsuar, JC; Afanvi, KA; Afarideh, M; Agarwal, G; Aggarwal, A; Aghayan, SA; Agrawal, A; Agrawal, S; Ahmadi, A; Ahmadi, M; Ahmadieh, H; Ahmed, MB; Aichour, AN; Aichour, I; Aichour, MTE; Akbari, ME; Akinyemiju, T; Akseer, N; Al-Aly, Z; Al-Eyadhy, A; Al-Mekhlafi, HM; Alahdab, F; Alam, K; Alam, S; Alam, T; Alashi, A; Alavian, SM; Alene, KA; Ali, K; Ali, SM; Alijanzadeh, M; Alizadeh-Navaei, R; Aljunid, SM; Alkerwi, A; Alla, F; Alsharif, U; Altirkawi, K; Alvis-Guzman, N; Amare, AT; Ammar, W; Anber, NH; Anderson, JA; Andrei, CL; Androudi, S; Animut, MD; Anjomshoa, M; Ansha, MG; Antó, JM; Antonio, CAT; Anwari, P; Appiah, LT; Appiah, SCY; Arabloo, J; Aremu, O; Ärnlöv, J; Artaman, A; Aryal, KK; Asayesh, H; Ataro, Z; Ausloos, M; Avokpaho, EFGA; Awasthi, A; Ayala Quintanilla, BP; Ayer, R; Ayuk, TB; Azzopardi, PS 2019-06-22 Department of Error. Journal Article 2019-06-22T00:00:00Z