Mold-Templated Inorganic-Organic Hybrid Supraparticles for Code livery of Drugs
AuthorMaina, JW; Cui, J; Bjoernmalm, M; Wise, AK; Shepherd, RK; Caruso, F
PublisherAMER CHEMICAL SOC
University of Melbourne Author/sCaruso, Francesco; Wise, Andrew; Cui, Jiwei; Shepherd, Robert; Bjornmalm, Axel; Bjornmalm, Axel Mattias Hekansson; MAINA, JAMES
Chemical and Biomolecular Engineering
Document TypeJournal Article
CitationsMaina, JW; Cui, J; Bjoernmalm, M; Wise, AK; Shepherd, RK; Caruso, F, Mold-Templated Inorganic-Organic Hybrid Supraparticles for Code livery of Drugs, BIOMACROMOLECULES, 2014, 15 (11), pp. 4146 - 4151
Access StatusOpen Access
This paper reports a facile and robust mold-templated technique for the assembly of mesoporous silica (MS) supraparticles and demonstrates their potential as vehicles for codelivery of brain-derived neurotrophic factor (BDNF) and dexamethasone (DEX). The MS supraparticles are assembled using gelatin as a biodegradable adhesive to bind and cross-link the particles. Microfabricated molds made of polydimethylsiloxane are used to control the size and shape of the supraparticles. The obtained mesoporous silica-gelatin hybrid supraparticles (MSG-SPs) are stable in water as well as in organic solvents, such as dimethyl sulfoxide, and efficiently coencapsulate both BDNF and DEX. The MSG-SPs also exhibit sustained release kinetics in simulated physiological conditions (>30 days), making them potential candidates for long-term delivery of therapeutics to the inner ear.
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