Pericytes as microenvironmental regulators of skin tissue regeneration and skin ageing
AffiliationSir Peter MacCallum Department of Oncology
Document TypePhD thesis
Access StatusOnly available to University of Melbourne staff and students, login required
© 2016 Dr. Lizhe Zhuang
This study focuses on how pericytes can contribute to the epidermal cell microenvironment in human skin, using a 3D organotypic co-culture model, I have shown that in the presence of pericytes, epidermal cells regenerate an epithelium that more closely resemble normal healthy skin with respect to basal cell morphology and various biochemical characteristics. Characterization of pericytes in skin ageing and their functionality in organotypic co-culture model suggests a microenvironmental modulatory role of pericytes in skin ageing and epithelial tissue repair.
Keywordspericyte; microenvironment; regeneration; ageing
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