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A new way of measuring apoptosis by absolute quantitation of inter-nucleosomally fragmented genomic DNA (OXFORD UNIV PRESS, 2012-08-01)Several critical events of apoptosis occur in the cell nucleus, including inter-nucleosomal DNA fragmentation (apoptotic DNA) and eventual chromatin condensation. The generation of apoptotic DNA has become a biochemical ...
Comparison of HDAC inhibitors in clinical development Effect on HIV production in latently infected cells and T-cell activation (TAYLOR & FRANCIS INC, 2013-05-01)OBJECTIVE: We aimed to compare the potential for inducing HIV production and the effect on T-cell activation of potent HDAC inhibitors undergoing clinical investigation. DESIGN: In vitro study RESULTS: The various HDAC ...
The interaction of macrophage and non-macrophage tropic isolates of HIV-1 with thymic and tonsillar dendritic cells in vitro (ROCKEFELLER UNIV PRESS, 1996-04-01)Dendritic cells isolated from thymus and tonsil were tested for susceptibility to HIV-1 strains that are tropic for macrophages or for T cell lines. DCs were purified by cell sorting and before infection expressed high ...