Doherty Institute - Research Publications
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The end of HIV: Still a very long way to go, but progress continues
(PUBLIC LIBRARY SCIENCE, 2017-11-01)
In an Editorial accompanying PLOS Medicine's Special Issue on Advances in Prevention, Treatment and Cure of HIV/AIDS, Guest Editors Steven Deeks, Sharon Lewin, and Linda-Gail Bekker discuss priorities in the field and the ...
Predictors and incidence of sexually transmitted Hepatitis C virus infection in HIV positive men who have sex with men
(BIOMED CENTRAL LTD, 2017-03-02)
BACKGROUND: Sexual transmission of Hepatitis C virus (HCV) in men who have sex with men (MSM) and its interaction with HIV status, sexually transmitted infections and sexual behaviour is poorly understood. We assessed the ...
A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals.
(2017)
BACKGROUND: In HIV infection, lymphoid tissue is disrupted by fibrosis. Angiotensin converting enzyme inhibitors have anti-fibrotic properties. We completed a pilot study to assess whether the addition of lisinopril to ...
HIV/Human herpesvirus co-infections: Impact on tryptophan-kynurenine pathway and immune reconstitution
(PUBLIC LIBRARY SCIENCE, 2017-10-09)
BACKGROUND: Co-infections with human herpesvirus (HHV) have been associated with residual chronic inflammation in antiretroviral (ART)-treated human immunodeficiency virus (HIV)-infected individuals. However, the role of ...
Characterising pandemic severity and transmissibility from data collected during first few hundred studies
(ELSEVIER SCIENCE BV, 2017-06-01)
Early estimation of the probable impact of a pandemic influenza outbreak can assist public health authorities to ensure that response measures are proportionate to the scale of the threat. Recently, frameworks based on ...
Identifying Key Drivers of the Impact of an HIV Cure Intervention in Sub-Saharan Africa
(OXFORD UNIV PRESS INC, 2016-07-01)
BACKGROUND: It is unknown what properties would be required to make an intervention in low income countries that can eradicate or control human immunodeficiency virus (HIV) without antiretroviral therapy (ART) cost-effective. ...
Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1
(NATURE PUBLISHING GROUP, 2011-11-01)
Hypovolemic shock (dengue shock syndrome (DSS)) is the most common life-threatening complication of dengue. We conducted a genome-wide association study of 2,008 pediatric cases treated for DSS and 2,018 controls from ...
Vaccine efficacy against Indonesian Highly Pathogenic Avian Influenza H5N1: systematic review and meta-analysis
(ELSEVIER SCI LTD, 2017-09-05)
Indonesia has implemented multiple strategies to control Highly Pathogenic Avian Influenza H5N1 (HPAI/H5N1), including the licensure and use of multiple vaccine formulations. The continuous drift of Indonesian HPAI/H5N1 ...
Seroepidemiologic Effects of Influenza A(H1N1)pdm09 in Australia, New Zealand, and Singapore
(CENTERS DISEASE CONTROL, 2013-01-01)
To estimate population attack rates of influenza A(H1N1)pdm2009 in the Southern Hemisphere during June-August 2009, we conducted several serologic studies. We pooled individual-level data from studies using hemagglutination ...
Whole genome sequencing reveals extensive community-level transmission of group A Streptococcus in remote communities
(CAMBRIDGE UNIV PRESS, 2016-07-01)
Impetigo is common in remote Indigenous children of northern Australia, with the primary driver in this context being Streptococcus pyogenes [or group A Streptococcus (GAS)]. To reduce the high burden of impetigo, the ...
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