Doherty Institute - Research Publications
Now showing items 1-10 of 133
TM4SF20 Ancestral Deletion and Susceptibility to a Pediatric Disorder of Early Language Delay and Cerebral White Matter Hyperintensities
(CELL PRESS, 2013-08-08)
White matter hyperintensities (WMHs) of the brain are important markers of aging and small-vessel disease. WMHs are rare in healthy children and, when observed, often occur with comorbid neuroinflammatory or vasculitic ...
A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis
(OXFORD UNIV PRESS INC, 2006-10-15)
BACKGROUND: Although meningitis is the most severe form of infection caused by Mycobacterium tuberculosis, the immunopathogenesis of this disease is poorly understood. We tested the hypothesis that polymorphisms in ...
TNF-alpha blockade suppresses pericystic inflammation following anthelmintic treatment in porcine neurocysticercosis
(PUBLIC LIBRARY SCIENCE, 2017-11-01)
BACKGROUND: Neurocysticercosis (NCC) is an infection of the brain with the larval cyst of the tapeworm, Taenia solium. Cysticidal treatment induces parasite killing resulting in a post inflammatory response and seizures, ...
A 2-Substituted 8-Hydroxyquinoline Stimulates Neural Stem Cell Proliferation by Modulating ROS Signalling
(HUMANA PRESS INC, 2016-09-01)
Eight-hydroxyquinolines (8HQs) are a class of compounds that have been identified as potential therapeutics for a number of neurodegenerative diseases. Understanding the influence of structural modifications to the 8HQ ...
Differences in reported sepsis incidence according to study design: a literature review
BACKGROUND: Sepsis and severe sepsis are common conditions in hospital settings, and are associated with high rates of morbidity and mortality, but reported incidences vary considerably. In this literature review, we ...
Bacterial risk factors for treatment failure and relapse among patients with isoniazid resistant tuberculosis
(BIOMED CENTRAL LTD, 2018-03-06)
BACKGROUND: Drug resistant tuberculosis (TB) is increasing in prevalence worldwide. Treatment failure and relapse is known to be high for patients with isoniazid resistant TB treated with standard first line regimens. ...
Implications of asymptomatic carriers for infectious disease transmission and control
(ROYAL SOC, 2018-02-01)
For infectious pathogens such as Staphylococcus aureus and Streptococcus pneumoniae, some hosts may carry the pathogen and transmit it to others, yet display no symptoms themselves. These asymptomatic carriers contribute ...
Variation in human genes encoding adhesion and proinflammatory molecules are associated with severe malaria in the Vietnamese
(NATURE PUBLISHING GROUP, 2012-09-01)
The genetic basis for susceptibility to malaria has been studied widely in African populations but less is known of the contribution of specific genetic variants in Asian populations. We genotyped 67 single-nucleotide ...
Metabolically active CD4+T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection
High glucose transporter 1 (Glut1) surface expression is associated with increased glycolytic activity in activated CD4+ T cells. Phosphatidylinositide 3-kinases (PI3K) activation measured by p-Akt and OX40 is elevated in ...
Steps to solving the infant biometric problem with ridge-based biometrics
(INST ENGINEERING TECHNOLOGY-IET, 2018-11-01)