Doherty Institute - Theses
Now showing items 1-10 of 19
Mucosal associated invariant T cell-mediated vaccination and protection against pathogenic bacteria
Mucosal Associated Invariant T (MAIT) cells are a subset of innate-like T cells, which are abundant in humans. They recognize antigens that are derived from bacterial riboflavin synthesis pathway metabolites, presented by ...
Assessment of antibody-dependent cellular cytotoxicity (ADCC) during human influenza infection, vaccination and immunotherapy
Despite the availability of influenza vaccines and antiviral therapies, human influenza virus infections cause approximately half a million deaths and five million cases of severe illness each year. Seasonal influenza ...
Investigating alternative strategies for the prevention of pneumococcal colonisation and disease
Streptococcus pneumoniae (the pneumococcus) is an important respiratory pathogen that colonises the human nasopharynx. While generally asymptomatic, colonisation is a prerequisite for disease. Infants are exposed to ...
Circulating and local IFN-g-mediated immunity to Salmonella Typhimurium infections to mice
Bacterial infections that are chiefly caused by food or water contaminated with Salmonella enterica lead to major health-threatening problems worldwide. In developing countries, where sanitation conditions and health ...
Transcriptional and epigenetic signatures of memory CD8+ T cell differentiation
Immunological memory is a hallmark feature of the adaptive immune system, providing superior protection against re-infection with previously encountered pathogens. Memory in CD8+ T cells is characterised by rapid effector ...
The clinical application of whole-genome sequencing to the surveillance, understanding, and control of bacterial infectious diseases in Australia
The scientific advance of whole-genome sequencing (WGS) has revolutionised the field of microbiology, with the ability to examine, characterise and compare organisms at a DNA sequence level. In recent years, the improving ...
An evaluation of charged Pam2Cys-based lipopeptides as novel adjuvants for subunit-based vaccines
The use of subunit antigens in modern vaccines generally requires the addition of an adjuvant due to the lack of immunostimulatory features that would otherwise allow them to induce strong immune responses. A problem facing ...
The interface of nanotechnology and the human immune system
Harnessing nanomaterials for the benefit of human health has the potential to improve drug delivery, vaccination and diagnostic imaging. However, a greater understanding of the interaction between nanomaterials and the ...
Strategies for the elicitation of broadly neutralising antibodies to the HIV-1 envelope protein
An effective prophylactic vaccine for HIV will likely require the elicitation of neutralising antibodies directed towards the Envelope protein (Env) of HIV. In particular, broadly neutralising antibodies (bNAbs) capable ...
Interaction of mouse norovirus (MNV) with the cellular immune response of host cells
Human noroviruses (HuNoV) cause the majority of non-bacterial gastroenteritis cases worldwide and generate an economic burden of 60 billion USD every year. Noroviruses are highly infectious and predominantly cause issues ...