Immunological memory is a hallmark feature of the adaptive immune system, providing superior protection against re-infection with previously encountered pathogens. Memory in CD8+ T cells is characterised by rapid effector ...

The scientific advance of whole-genome sequencing (WGS) has revolutionised the field of microbiology, with the ability to examine, characterise and compare organisms at a DNA sequence level. In recent years, the improving ...

The use of subunit antigens in modern vaccines generally requires the addition of an adjuvant due to the lack of immunostimulatory features that would otherwise allow them to induce strong immune responses. A problem facing ...

Harnessing nanomaterials for the benefit of human health has the potential to improve drug delivery, vaccination and diagnostic imaging. However, a greater understanding of the interaction between nanomaterials and the ...

An effective prophylactic vaccine for HIV will likely require the elicitation of neutralising antibodies directed towards the Envelope protein (Env) of HIV. In particular, broadly neutralising antibodies (bNAbs) capable ...

Human noroviruses (HuNoV) cause the majority of non-bacterial gastroenteritis cases worldwide and generate an economic burden of 60 billion USD every year. Noroviruses are highly infectious and predominantly cause issues ...

A prophylactic vaccine eliciting broadly neutralising antibody (bNAb) responses against HIV-1 envelope glycoprotein (Env) would be optimal to prevent HIV-1 transmission. Replication incompetent HIV-1 virus-like particles ...

Dendritic cells (DCs) are the most potent initiators of immune responses, being highly specialised for the uptake and presentation of antigens (Ag) to activate T cells. Their priming potential can be harnessed to generate ...

Characterising the mechanistic principles underlying immune function and regulation will help us understand how the immune system provides effective host defence. However, the highly complex and multi-level nature of the ...

Helicobacter pylori infects the human stomach of approximately half the world’s population and is aetiologically associated with a range of pathologies including gastritis, duodenal ulcers and gastric cancer. The development ...