The malaria vaccine candidate Apical Membrane Antigen 1 – antigenic diversity and its potential as effective multi-allele vaccine
AffiliationMelbourne Medical School Collected Works
Access StatusThis item is currently not available from this repository
© 2016 Dr. Ulrich Terheggen
Understanding naturally acquired immunity to malaria and how human antibodies protect against clinical malaria is essential for vaccine development. Antibodies against Plasmodium falciparum apical membrane antigen 1 (AMA1), a leading vaccine candidate, can inhibit merozoite invasion of erythrocytes and protect from P. falciparum malaria. However, polymorphism in antigens like AMA1 is a common mechanism for immune evasion and presents major challenges in vaccine development. This study aims to understand antigenic diversity of AMA1, the correlation between sequence polymorphism and antigenic differences, the impact of polymorphism on potential vaccine escape, and the structural differences of the protein amongst various alleles, with the goal to ultimately ascertain which AMA1 alleles should be included in an effective multi-allele vaccine.
Keywordsvaccine development; malaria; AMA1; immunology
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References