Dynamic Flow Impacts Cell-Particle Interactions: Sedimentation and Particle Shape Effects
AuthorBjornmalm, M; Faria, M; Chen, X; Cui, J; Caruso, F
PublisherAMER CHEMICAL SOC
University of Melbourne Author/sCaruso, Francesco; Cui, Jiwei; CHEN, XI; Bjornmalm, Axel Mattias Hekansson; Faria, Matthew William; Faria, Matthew
AffiliationChemical and Biomolecular Engineering
Mathematics and Statistics
Document TypeJournal Article
CitationsBjornmalm, M; Faria, M; Chen, X; Cui, J; Caruso, F, Dynamic Flow Impacts Cell-Particle Interactions: Sedimentation and Particle Shape Effects, LANGMUIR, 2016, 32 (42), pp. 10995 - 11001
Access StatusOpen Access
The interaction of engineered particles with biological systems determines their performance in biomedical applications. Although standard static cell cultures remain the norm for in vitro studies, modern models mimicking aspects of the dynamic in vivo environment have been developed. Herein, we investigate fundamental cell-particle interactions under dynamic flow conditions using a simple and self-contained device together with standard multiwell cell culture plates. We engineer two particle systems and evaluate their cell interactions under dynamic flow, and we compare the results to standard static cell cultures. We find substantial differences between static and dynamic flow conditions and attribute these to particle shape and sedimentation effects. These results demonstrate how standard static assays can be complemented by dynamic flow assays for a more comprehensive understanding of fundamental cell-particle interactions.
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