Are long stimulus pulse durations the answer to improving spatial resolution in retinal prostheses?
AuthorPetoe, MA; Shivdasani, MN
Source TitleANNALS OF TRANSLATIONAL MEDICINE
PublisherAME PUBL CO
Document TypeJournal Article
CitationsPetoe, MA; Shivdasani, MN, Are long stimulus pulse durations the answer to improving spatial resolution in retinal prostheses?, ANNALS OF TRANSLATIONAL MEDICINE, 2016, 4 (21)
Access StatusAccess this item via the Open Access location
Open Access URLhttps://www.ncbi.nlm.nih.gov/pubmed/27942525
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124616
NHMRC Grant codeNHMRC/1063093
Retinal prostheses can provide artificial vision to patients with degenerate retinae by electrically stimulating the remaining inner retinal neurons. The evoked perception is generally adequate for light localization, but of limited spatial resolution owing to the indiscriminate activation of multiple retinal cell types, leading to distortions in the perceived image. Here we present a perspective on a recent work by Weitz and colleagues who demonstrate a focal confinement of retinal ganglion cell (RGC) activation when using extended pulse durations in the stimulation waveform. Using real-time calcium imaging, they provide evidence that long pulse durations selectively stimulate inner retinal neurons, whilst avoiding unwanted axonal activations. The application of this stimulation technique may provide enhanced spatial resolution for retinal prosthesis users. These experiments provide a robust analysis of the effects of increasing pulse duration and introduce the potential for alternative stimulation paradigms in retinal prostheses.
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References