Surgery (St Vincent's) - Theses
Now showing items 1-8 of 8
Investigating epithelial-mesenchymal plasticity in breast cancer using circulating tumour cells and circulating tumour DNA
Breast cancer is the most frequent invasive cancer among women worldwide with mortality primarily caused by metastasis. One of the key proposed processes underlying metastasis, including the escape to the bloodstream, is ...
Constructing a neuromuscular-prosthetic interface and actuator system for limb reconstruction
A neuromuscular prosthesis provides an ideal solution to functional restoration of the limb after amputation. In such a system, the severed nerves at the stump are implanted into denervated muscles and the innervated muscle ...
Selection and management of men for active surveillance in low risk prostate cancer
Aims: To investigate: 1. Selection of men for active surveillance of prostate cancer a. Validation of risk calculators b. Suitability for inclusion of Gleason 3+4 disease. 2. Performance of prostate biopsy during ...
Biocellular aspects of high mammographic density as a risk factor for breast cancer
High mammographic density (MD) is one of the strongest risk factors for breast cancer after high-risk mutations, with a 4-6 fold increased risk comparing the highest to lowest MD quartiles. MD is of great clinical relevance, ...
Thromboembolism and neoadjuvant chemoradiation for rectal cancer
Thromboembolism (TE) is one of the leading causes of morbidity and mortality in cancer, is an independent predictor of reduced survival, and the overall rate of TE in cancer patients is increasing. Assessing the TE risk ...
Engineering articular cartilage from human infrapatellar fat pad stem cells for transplantation therapy
Mesenchymal stem cells (MSCs) have shown promise in cartilage tissue engineering due to their unlimited capacity for self-renewal and capability to differentiate into cartilage tissue lineage under certain physiological ...
Cardiac surgery using cardiopulmonary bypass in adult patients, effects of pre-operative insulin resistance and the metabolic syndrome, dimethylamine dimethylaminohydrolase activity, and vasoreactivity of regional adipose tissue
Introduction: Atherosclerosis and coronary artery disease (CAD) are accelerated in Diabetes mellitus (DM) and the Metabolic Syndrome (MS). Insulin Resistance (IR) is thought to be central in its pathogenesis. Recently, ...
Prediction of chemotherapy-induced hepatic injuries on clinical, imaging and genetic parameters following treatment of colorectal carcinoma
Chemotherapy-induced hepatic injuries (CIHI) are an increasingly common and serious problem facing clinicians. Peri-operative outcomes following hepatic resection are inferior in patients with severely injured livers. ...