Surgery (St Vincent's) - Theses
Now showing items 1-10 of 35
Combining TIL and CAR for adoptive cell therapy in metastatic melanoma
Background Metastatic melanoma is a highly lethal disease, and until recently patients had limited therapeutic options. Knowledge and understanding of the role the immune system plays in tumour development and its ...
Strategies for engineering skeletal muscle: an important link in the neuroprosthetic interface of bionic limbs
Limb amputation is a major cause of disability in our community, for which motorised prosthetic devices offer a return to function and independence. Advanced robotic limb technology utilises a range of mind-prosthetic ...
Assessment of the anabolic effects of PTH drug treatment and mechanical loading on bone using high-resolution imaging and in silico modelling
Osteoporosis (OP) is a progressive bone disease characterised by significant reduction of bone mineral density (BMD) due to loss of bone matrix and changes in bone tissue properties. OP is regarded as a worldwide health ...
Identifying functional drivers of epithelial-mesenchymal transition (EMT) in human breast cancer: the integrin/ILK axis
Breast cancer is the leading cause of cancer in women worldwide, and over 90% of deaths caused by breast cancer are due to metastases, many of which are not responsive to current therapies. The ability for cells to acquire ...
Using transcriptomics to understand cancer progression and predict response to therapy
Transcriptomics data provide useful information to better understand molecular phenotypes in cancer. Epithelial-to-mesenchymal transition (EMT) is one of these molecular phenotypes that is hijacked by cancer cells to obtain ...
Analysis of C-peptide-specific CD4+ T cells in the peripheral blood of people with type 1 diabetes
Uncovering the primary antigen targets in type 1 diabetes (T1D) is essential to our understanding of disease pathophysiology. Despite the clear role of CD4+ T cells in orchestrating the immune destruction of the pancreatic ...
Development and validation of a novel marker tracking approach based on the low-cost Microsoft Kinect v2 sensor for assessing lower limb biomechanics during single-leg squat and treadmill gait
Pubescent females are twice more likely to suffer a non-contact ACL injury than their male counterparts. This disparity has been correlated with multiple concurrent factors, including biomechanical, anatomical and hormonal ...
Profiling desmoid tumours and exploring new strategies to prevent and treat desmoid tumours in familial adenomatous polyposis using a novel mouse model
Desmoid tumour is a benign growth that causes morbidity and mortality from local enlargement. Desmoids are thought to result from dysfunction in WNT signalling. Trauma, including that from surgical intervention, is ...
The impact of sex differences on host and tumour prognostic factors in patients with non-small cell lung cancer
Epidemiological studies demonstrate that women live longer than men following diagnosis of non-small cell lung cancer (NSCLC) even after controlling for prognostic factors. This study examines the one biological trait all ...
Radiation-associated breast, thyroid and solid malignancies in patients attending the Peter MacCallum Cancer Centre Late Effects service
Background: Survivors of childhood, adolescent and young adulthood (CAYA) malignancies have an increased risk of subsequent primary malignancies, particularly after exposure to therapeutic radiation. The Peter MacCallum ...