Surgery (St Vincent's) - Theses
Now showing items 1-10 of 28
Profiling desmoid tumours and exploring new strategies to prevent and treat desmoid tumours in familial adenomatous polyposis using a novel mouse model
Desmoid tumour is a benign growth that causes morbidity and mortality from local enlargement. Desmoids are thought to result from dysfunction in WNT signalling. Trauma, including that from surgical intervention, is ...
The impact of sex differences on host and tumour prognostic factors in patients with non-small cell lung cancer
Epidemiological studies demonstrate that women live longer than men following diagnosis of non-small cell lung cancer (NSCLC) even after controlling for prognostic factors. This study examines the one biological trait all ...
Radiation-associated breast, thyroid and solid malignancies in patients attending the Peter MacCallum Cancer Centre Late Effects service
Background: Survivors of childhood, adolescent and young adulthood (CAYA) malignancies have an increased risk of subsequent primary malignancies, particularly after exposure to therapeutic radiation. The Peter MacCallum ...
Prediction and prognosis in anal cancer: developing models to improve patient outcome
Anal squamous cell carcinoma is a human papilloma virus–related disease for which definitive treatment comprises chemoradiotherapy that has not changed substantially for forty years. Few advances in treatment have been ...
Defining lymphatic microstructure and the genetic basis of lipolymphedema
The lymphatic system regulates tissue fluid homeostasis, intestinal fat absorption, and immune cell trafficing. Lymphedema is soft tissue swelling secondary to lymphatic dysfunction, which results in the accumulation of ...
Toward a functional and permanent interface between materials and skin
All medical devices that pass through skin are plagued by infection and other problems at the skin interface. Such devices include intravenous lines, catheters, robotics, osseointegrated rods, bone anchored hearing aids, ...
Using a murine bioengineering model to study cancer cell biology: the effects of mammographic density on breast cancer progression
Breast cancer (BC) remains a leading cause of cancer-related morbidity and mortality for women worldwide. Mammographic density (MD) has been well recognized as a strong risk factor for BC, independent of its masking effect ...
Investigating epithelial-mesenchymal plasticity in breast cancer using circulating tumour cells and circulating tumour DNA
Breast cancer is the most frequent invasive cancer among women worldwide with mortality primarily caused by metastasis. One of the key proposed processes underlying metastasis, including the escape to the bloodstream, is ...
Constructing a neuromuscular-prosthetic interface and actuator system for limb reconstruction
A neuromuscular prosthesis provides an ideal solution to functional restoration of the limb after amputation. In such a system, the severed nerves at the stump are implanted into denervated muscles and the innervated muscle ...
Selection and management of men for active surveillance in low risk prostate cancer
Aims: To investigate: 1. Selection of men for active surveillance of prostate cancer a. Validation of risk calculators b. Suitability for inclusion of Gleason 3+4 disease. 2. Performance of prostate biopsy during ...