• A role for CCL2 in both tumor progression and immunosurveillance 

  Li, M; Knight, DA; Snyder, LA; Smyth, MJ; Stewart, TJ (TAYLOR & FRANCIS INC, 2013-07-01)

  The chemokine CCL2, which is best known for its chemotactic functions, is expressed not only by immune cells, but also by several types of malignant and stromal cells. CCL2 has been shown to exert both pro- and anti-tumor ...

• Tumor necrosis factor is dispensable for the success of immunogenic anticancer chemotherapy 

  Ma, Y; Yamazaki, T; Yang, H; Kepp, O; Galluzzi, L; Zitvogel, L; Smyth, MJ; Kroemer, G (TAYLOR & FRANCIS INC, 2013-06-01)

  The antineoplastic effects of anthracyclines have been shown to rely, at least in part, on a local immune response that involves dendritic cells (DCs) and several distinct subsets of T lymphocytes. Here, we show that the ...

• Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis 

  Waterhouse, NJ; Sutton, VR; Sedelies, KA; Ciccone, A; Jenkins, M; Turner, SJ; Bird, PI; Trapani, JA (ROCKEFELLER UNIV PRESS, 2006-04-10)

  Cytotoxic T lymphocyte (CTL)-induced death triggered by the granule exocytosis pathway involves the perforin-dependent delivery of granzymes to the target cell. Gene targeting has shown that perforin is essential for this ...

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