Pathology - Research Publications

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Can we detect altered disease state in early stage Huntington’s Disease using acoustic markers of speech?

Vogel, A. P.; Shirbin, C.; Churchyard, A. J.; Stout, J. C. (Causal Productions, 2012)

Altered prosody has been described in symptomatic Huntington’s Disease (HD) individuals, however, the extent to which acoustic analysis of speech is sensitive to gene positive pre-manifest (PreHD) individuals is unknown. ...

Dysphagia and swallowing-related quality of life in Friedreich ataxia

Vogel, Adam P.; Brown, Sophie E.; Folker, Joanne E.; Corben, Louise A.; Delatycki, Martin B. (Springer, 2014)

Dysphagia in Friedreich ataxia (FRDA) and its impact on quality of life is not adequately understood. The objective of this study was to characterise dysphagia in FRDA and to determine the impact of swallowing dysfunction ...

The sensitivity of CD138 immunostaining of bone marrow trephine specimens for quantifying marrow involvement in MGUS and myeloma,including samples with a low percentage of plasma cells

Ng, Ashley P; WEI, ANDREW; Bhurani, Dinesh; Chapple, Peter; Feleppa, Frank; JUNEJA, SURENDER (European Hematology Association, 2006)

Accurate quantification of plasma cells in bone marrow samples is essential for the diagnosis, classification and prognosis of plasma-cell dyscrasias. Published comparisons between aspirate/trephine morphology, flow cytometry ...

Levels of [(3)H]pirenzepine binding in Brodmann's area 6 from subjects with schizophrenia is not associated with changes in the transcription factor S

DEAN, BRIAN; SOULBY, ANDREW; EVIN, GENEVIEVE; SCARR, ELIZABETH (2008)

Vocal Acoustic Biomarkers of Depression Severity and Treatment Response

Mundt, JC; Vogel, AP; Feltner, DE; Lenderking, WR (ELSEVIER SCIENCE INC, 2012-10-01)

BACKGROUND: Valid, reliable biomarkers of depression severity and treatment response would provide new targets for clinical research. Noticeable differences in speech production between depressed and nondepressed patients ...

Speech acoustic markers of early stage and prodromal Huntington's disease: A marker of disease onset?

Vogel, AP; Shirbin, C; Churchyard, AJ; Stout, JC (PERGAMON-ELSEVIER SCIENCE LTD, 2012-12-01)

Speech disturbances (e.g., altered prosody) have been described in symptomatic Huntington's Disease (HD) individuals, however, the extent to which speech changes in gene positive pre-manifest (PreHD) individuals is largely ...