Ophthalmology (Eye & Ear Hospital) - Theses
Now showing items 1-10 of 52
Investigating the pharmacogenetic basis of Age-related Macular Degeneration (AMD) with anti-VEGF treatments
Age-related macular degeneration (AMD) is a leading cause of irreversible central vision loss and blindness in elderly people in the developed world. The two main vision threating subtypes are geographic atrophy (GA) and ...
Molecular investigations into the patho-aetiology of giant cell arteritis
Giant cell arteritis (GCA) is the most common form of vasculitis in people over 50 years of age. It is characterized by inflammation of the medium and large arteries of the head and neck. When the ophthalmic artery is ...
Role of microRNAs in retinal neovascularization
MicroRNAs (miRNAs) are master gene regulators that have been widely implicated in many biological processes as well as pathogenesis of many diseases in the eye. The identification of miRNAs that are altered in human diseases ...
The prevalence and causes of vision impairment and blindness in Australia: the National Eye Health Survey
Vision impairment (VI) and blindness affect 440 million people worldwide. As most cases can be avoided through evidence-based eye health care interventions, the elimination of avoidable VI and blindness is a global health ...
Signalling molecules involved in the maintenance and differentiation of human pluripotent stem cells and retinal pigment epithelial cells
To study diseases affecting the retina, we rely on appropriate models to investigate causes of degenerative onset and progression. Human pluripotent stem cells (hPSCs), and in particular patient-specific induced pluripotent ...
Ocular manifestations of neurologic disease in early childhood
Neuro-ophthalmology is a medical discipline focusing on diseases of the central nervous system that may affect the visual sensory or motor systems or pupillary reflexes. Neuro-ophthalmologists are often part of the academic ...
Second eye at risk: predicting the development of advanced age-related macular degeneration
Hypothesis 1: In people who develop a choroidal neovascular membrane (CNVM) secondary to Age-Related Macular Degeneration (AMD), presenting visual acuity varies. Eyes with worse visual acuities at presentation have worse ...
Improving depressive symptoms in adults with vision impairment: a trial of evidence-based ‘Problem-Solving Treatment' integrated within low vision rehabilitation services
Depression is exceedingly prevalent in people with vision impairment (VI), which further exacerbates vision-related functioning, disability and quality of life when left untreated.1-5 Up to 43% of people with VI experience ...
Genetic and functional studies of myopia: identifying differential gene expression in sclera and the importance of genetic variants in myopia
Myopia is a refractive error characterized by an abnormal increase in eye length. There has been a rapid increase in the prevalence of myopia in the world and concomitant with this, are the increased number of individuals ...
Task sharing in the eye care workforce: screening, detection and management of diabetic retinopathy in low resource settings
Using a mixed method approach, this research was conducted in three phases. In Phase 1, a situation analysis was conducted through a survey and interviews with ophthalmologists, health administrators, mid-level eye care ...