Background: Affecting one or both eyes, retinoblastoma is the most common intraocular neoplasm occurring in children under the age of 5 years. The most frequent presenting signs of retinoblastoma include leukocoria and ...

Glaucoma is one of the leading causes of irreversible blindness and early detection and treatment are key to preventing or slowing the progression of vision loss. An objective, non-invasive method to detect early functional ...

Background Age-related macular degeneration (AMD) is a complex multifactorial disease that affects the elderly. In the early stages of disease, dark adaptation problems are more significant for patients than visual acuity ...

The overwhelming majority of the world’s vision impaired reside in low-income settings. Cataract is the leading cause of blindness and the second-leading cause of moderate to severe vision impairment (MSVI). Proxy measures ...

Glaucoma is a group of optic neuropathies that may be characterized by gradual degeneration of retinal ganglion cells (RGCs) and their axons leading to irreversible vision loss [1, 2]. Glaucoma is the second leading cause ...

Age-related macular degeneration (AMD) is a leading cause of irreversible central vision loss and blindness in elderly people in the developed world. The two main vision threating subtypes are geographic atrophy (GA) and ...

Giant cell arteritis (GCA) is the most common form of vasculitis in people over 50 years of age. It is characterized by inflammation of the medium and large arteries of the head and neck. When the ophthalmic artery is ...

MicroRNAs (miRNAs) are master gene regulators that have been widely implicated in many biological processes as well as pathogenesis of many diseases in the eye. The identification of miRNAs that are altered in human diseases ...

Vision impairment (VI) and blindness affect 440 million people worldwide. As most cases can be avoided through evidence-based eye health care interventions, the elimination of avoidable VI and blindness is a global health ...

To study diseases affecting the retina, we rely on appropriate models to investigate causes of degenerative onset and progression. Human pluripotent stem cells (hPSCs), and in particular patient-specific induced pluripotent ...