Ophthalmology (Eye & Ear Hospital) - Theses
Now showing items 1-10 of 57
"A glint or a squint should make you think!": towards the earlier diagnosis of retinoblastoma
Background: Affecting one or both eyes, retinoblastoma is the most common intraocular neoplasm occurring in children under the age of 5 years. The most frequent presenting signs of retinoblastoma include leukocoria and ...
Optimising the clinical utility of the photopic negative response to probe changes in glaucoma
Glaucoma is one of the leading causes of irreversible blindness and early detection and treatment are key to preventing or slowing the progression of vision loss. An objective, non-invasive method to detect early functional ...
Topographic rod function in intermediate age-related macular degeneration
Background Age-related macular degeneration (AMD) is a complex multifactorial disease that affects the elderly. In the early stages of disease, dark adaptation problems are more significant for patients than visual acuity ...
The global socioeconomics of vision impairment and cataract surgery
The overwhelming majority of the world’s vision impaired reside in low-income settings. Cataract is the leading cause of blindness and the second-leading cause of moderate to severe vision impairment (MSVI). Proxy measures ...
Using induced pluripotent stem cells to model primary open-angle glaucoma
Glaucoma is a group of optic neuropathies that may be characterized by gradual degeneration of retinal ganglion cells (RGCs) and their axons leading to irreversible vision loss [1, 2]. Glaucoma is the second leading cause ...
Investigating the pharmacogenetic basis of Age-related Macular Degeneration (AMD) with anti-VEGF treatments
Age-related macular degeneration (AMD) is a leading cause of irreversible central vision loss and blindness in elderly people in the developed world. The two main vision threating subtypes are geographic atrophy (GA) and ...
Molecular investigations into the patho-aetiology of giant cell arteritis
Giant cell arteritis (GCA) is the most common form of vasculitis in people over 50 years of age. It is characterized by inflammation of the medium and large arteries of the head and neck. When the ophthalmic artery is ...
Role of microRNAs in retinal neovascularization
MicroRNAs (miRNAs) are master gene regulators that have been widely implicated in many biological processes as well as pathogenesis of many diseases in the eye. The identification of miRNAs that are altered in human diseases ...
The prevalence and causes of vision impairment and blindness in Australia: the National Eye Health Survey
Vision impairment (VI) and blindness affect 440 million people worldwide. As most cases can be avoided through evidence-based eye health care interventions, the elimination of avoidable VI and blindness is a global health ...
Signalling molecules involved in the maintenance and differentiation of human pluripotent stem cells and retinal pigment epithelial cells
To study diseases affecting the retina, we rely on appropriate models to investigate causes of degenerative onset and progression. Human pluripotent stem cells (hPSCs), and in particular patient-specific induced pluripotent ...