Pharmacology and Therapeutics
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Eukaryotic expression, purification and structure/function analysis of native, recombinant CRISP3 from human and mouse (NATURE PUBLISHING GROUP, 2014-02-27)While the Cysteine-Rich Secretory Proteins (CRISPs) have been broadly proposed as regulators of reproduction and immunity, physiological roles have yet to be established for individual members of this family. Past efforts ...
Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis (FRONTIERS RESEARCH FOUNDATION, 2014-02-11)Disrupted metal homeostasis is a consistent feature of neurodegenerative disease in humans and is recapitulated in mouse models of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS) and neuronal ...
(Hindawi Limited, 2013)Inflammation is the innate immune response to infection or tissue damage. Initiation of proinflammatory cascades in the central nervous system (CNS) occurs through recognition of danger associated molecular patterns by ...